Membrane-Targeted palGFP Predominantly Localizes to the Plasma Membrane but not to Neurosecretory Vesicle Membranes in Rat Oxytocin Neurons
This study indicates the importance of understanding the plasma membrane-specific sorting system in neuronal membrane migration and encourages future studies on the underlying mechanisms.PMID:38695035 | PMC:PMC11058463 | DOI:10.1267/ahc.24-00001 (Source: Acta Histochemica)
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Hirotaka Sakamoto Ayumu Inutsuka Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Clinicopathological Significance and Prognostic Role of High Mobility Group Box 1 (HMGB1), Toll-Like Receptor (TLR) 2 and TLR4 in Breast Cancer
Acta Histochem Cytochem. 2024 Apr 25;57(2):75-83. doi: 10.1267/ahc.24-00006. Epub 2024 Apr 17.ABSTRACTHigh-mobility group box 1 (HMGB1) functions as damage-associated molecular pattern (DAMPs), released into extracellular space during cellular stress. Extracellular HMGB1 act as signal molecules through Toll-like receptor (TLR) 2 or TLR4, exerting diverse functions in both normal cells and malignant cells including breast cancer. However, their comprehensive examination in breast cancer tissues is lacking. Thus, we immunolocalized them in 112 breast cancer tissues, correlating their immunoreactivity with clinicopathological...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Reina Taguchi Mio Yamaguchi-Tanaka Kiyoshi Takagi Ai Sato Yasuhiro Miki Minoru Miyashita Takashi Suzuki Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Membrane-Targeted palGFP Predominantly Localizes to the Plasma Membrane but not to Neurosecretory Vesicle Membranes in Rat Oxytocin Neurons
This study indicates the importance of understanding the plasma membrane-specific sorting system in neuronal membrane migration and encourages future studies on the underlying mechanisms.PMID:38695035 | PMC:PMC11058463 | DOI:10.1267/ahc.24-00001 (Source: Acta Histochemica)
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Hirotaka Sakamoto Ayumu Inutsuka Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Clinicopathological Significance and Prognostic Role of High Mobility Group Box 1 (HMGB1), Toll-Like Receptor (TLR) 2 and TLR4 in Breast Cancer
Acta Histochem Cytochem. 2024 Apr 25;57(2):75-83. doi: 10.1267/ahc.24-00006. Epub 2024 Apr 17.ABSTRACTHigh-mobility group box 1 (HMGB1) functions as damage-associated molecular pattern (DAMPs), released into extracellular space during cellular stress. Extracellular HMGB1 act as signal molecules through Toll-like receptor (TLR) 2 or TLR4, exerting diverse functions in both normal cells and malignant cells including breast cancer. However, their comprehensive examination in breast cancer tissues is lacking. Thus, we immunolocalized them in 112 breast cancer tissues, correlating their immunoreactivity with clinicopathological...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Reina Taguchi Mio Yamaguchi-Tanaka Kiyoshi Takagi Ai Sato Yasuhiro Miki Minoru Miyashita Takashi Suzuki Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
The link between autophagy and psoriasis
Acta Histochem. 2024 Apr 29;126(4):152166. doi: 10.1016/j.acthis.2024.152166. Online ahead of print.ABSTRACTAutophagy is a lysosome-dependent, self-renewal mechanism that degrades and recycles cellular components in eukaryotic cells to maintain the homeostasis of the intracellular environment. Psoriasis is featured by increased inflammatory response, epidermal hyperproliferation and abnormal differentiation, infiltration of immune cells and increased expression levels of both endothelial adhesion molecules and angiogenic mediators. Evidence indicates that autophagy has important roles in many different types of cells, such...
Source: Acta Histochemica - April 30, 2024 Category: Biochemistry Authors: Nannan Liang Kaiming Zhang Source Type: research
The link between autophagy and psoriasis
Acta Histochem. 2024 Apr 29;126(4):152166. doi: 10.1016/j.acthis.2024.152166. Online ahead of print.ABSTRACTAutophagy is a lysosome-dependent, self-renewal mechanism that degrades and recycles cellular components in eukaryotic cells to maintain the homeostasis of the intracellular environment. Psoriasis is featured by increased inflammatory response, epidermal hyperproliferation and abnormal differentiation, infiltration of immune cells and increased expression levels of both endothelial adhesion molecules and angiogenic mediators. Evidence indicates that autophagy has important roles in many different types of cells, such...
Source: Acta Histochemica - April 30, 2024 Category: Biochemistry Authors: Nannan Liang Kaiming Zhang Source Type: research
Immunohistochemical localization and expression of heat shock proteins (HSP27, HSP60, HSP70, and HSP90) during the oestrous cycle, pregnancy, and lactation in rat ovaries
In conclusion, HSP60 and HSP90 may participate in folliculogenesis, luteal development, and steroidogenesis in luteal cells, and HSP27, HSP60, HSP70, and HSP90 may be effective in luteal regression and steroidogenesis in interstitial cells. HSP27 and HSP70 may be used as markers to identify old CLs in rats.PMID:38581753 | DOI:10.1016/j.acthis.2024.152157 (Source: Acta Histochemica)
Source: Acta Histochemica - April 6, 2024 Category: Biochemistry Authors: Banu Kandil Nevin Kurtdede Alev G ürol Bayraktaroglu Source Type: research
Immunohistochemical localization and expression of heat shock proteins (HSP27, HSP60, HSP70, and HSP90) during the oestrous cycle, pregnancy, and lactation in rat ovaries
In conclusion, HSP60 and HSP90 may participate in folliculogenesis, luteal development, and steroidogenesis in luteal cells, and HSP27, HSP60, HSP70, and HSP90 may be effective in luteal regression and steroidogenesis in interstitial cells. HSP27 and HSP70 may be used as markers to identify old CLs in rats.PMID:38581753 | DOI:10.1016/j.acthis.2024.152157 (Source: Acta Histochemica)
Source: Acta Histochemica - April 6, 2024 Category: Biochemistry Authors: Banu Kandil Nevin Kurtdede Alev G ürol Bayraktaroglu Source Type: research
Immunohistochemical localization and expression of heat shock proteins (HSP27, HSP60, HSP70, and HSP90) during the oestrous cycle, pregnancy, and lactation in rat ovaries
In conclusion, HSP60 and HSP90 may participate in folliculogenesis, luteal development, and steroidogenesis in luteal cells, and HSP27, HSP60, HSP70, and HSP90 may be effective in luteal regression and steroidogenesis in interstitial cells. HSP27 and HSP70 may be used as markers to identify old CLs in rats.PMID:38581753 | DOI:10.1016/j.acthis.2024.152157 (Source: Acta Histochemica)
Source: Acta Histochemica - April 6, 2024 Category: Biochemistry Authors: Banu Kandil Nevin Kurtdede Alev G ürol Bayraktaroglu Source Type: research
Immunohistochemical localization and expression of heat shock proteins (HSP27, HSP60, HSP70, and HSP90) during the oestrous cycle, pregnancy, and lactation in rat ovaries
In conclusion, HSP60 and HSP90 may participate in folliculogenesis, luteal development, and steroidogenesis in luteal cells, and HSP27, HSP60, HSP70, and HSP90 may be effective in luteal regression and steroidogenesis in interstitial cells. HSP27 and HSP70 may be used as markers to identify old CLs in rats.PMID:38581753 | DOI:10.1016/j.acthis.2024.152157 (Source: Acta Histochemica)
Source: Acta Histochemica - April 6, 2024 Category: Biochemistry Authors: Banu Kandil Nevin Kurtdede Alev G ürol Bayraktaroglu Source Type: research
Immunohistochemical localization and expression of heat shock proteins (HSP27, HSP60, HSP70, and HSP90) during the oestrous cycle, pregnancy, and lactation in rat ovaries
In conclusion, HSP60 and HSP90 may participate in folliculogenesis, luteal development, and steroidogenesis in luteal cells, and HSP27, HSP60, HSP70, and HSP90 may be effective in luteal regression and steroidogenesis in interstitial cells. HSP27 and HSP70 may be used as markers to identify old CLs in rats.PMID:38581753 | DOI:10.1016/j.acthis.2024.152157 (Source: Acta Histochemica)
Source: Acta Histochemica - April 6, 2024 Category: Biochemistry Authors: Banu Kandil Nevin Kurtdede Alev G ürol Bayraktaroglu Source Type: research
