Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print.ABSTRACTEndothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nu...
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-Hua Zheng Jiao-Jiao Wang Jiu-Guo Lin Wei-le Ye Jia-Mi Zou Li-Yin Liang Ping-Lian Yang Wan-Lu Qiu Yuan-Yuan Li Si-Jia Yang Man Zhao Qing Zhou Cheng-Zhi Li Min Li Zhuo-Ming Li Dong-Mei Zhang Pei-Qing Liu Zhi-Ping Liu Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacologica Sinica, Published online: 30 April 2024; doi:10.1038/s41401-024-01281-0Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-hua Zheng Jiao-jiao Wang Jiu-guo Lin Wei-le Ye Jia-mi Zou Li-yin Liang Ping-lian Yang Wan-lu Qiu Yuan-yuan Li Si-jia Yang Man Zhao Qing Zhou Cheng-zhi Li Min Li Zhuo-ming Li Dong-mei Zhang Pei-qing Liu Zhi-ping Liu Source Type: research
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
This study demonstrates that ferroptosis contributes to baicalein-induced anti-CRC activity through blockade of the JAK2/STAT3/GPX4 signaling pathway, which provides evidence for the therapeutic application of baicalein against CRC.PMID:38684798 | DOI:10.1038/s41401-024-01258-z (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Jian-Qin Lai Le-le Zhao Chao Hong Qiu-Ming Zou Jin-Xuan Su Si-Jia Li Xiao-Feng Zhou Zi-Sheng Li Bo Deng Jie Cao Qi Qi Source Type: research
Kr üppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Acta Pharmacol Sin. 2024 Apr 29. doi: 10.1038/s41401-024-01285-w. Online ahead of print.ABSTRACTEpilepsy is a chronic and debilitating neurological disorder, known for the occurrence of spontaneous and recurrent seizures. Despite the availability of antiseizure drugs, 30% of people with epilepsy experience uncontrolled seizures and drug resistance, evidencing that new therapeutic options are required. The process of epileptogenesis involves the development and expansion of tissue capable of generating spontaneous recurrent seizures, during which numerous events take place, namely blood-brain barrier (BBB) dysfunction, and ...
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Ana Beatriz Santos Andreia Carona Miren Ettcheto Antoni Camins Am ílcar Falcão Ana Fortuna Joana Bicker Source Type: research
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
In conclusion, this study supports the concept that intake of MCD predisposes to experimental colitis and enhances its pathogenesis via modulating gut microbes and macrophages in mice.PMID:38684800 | DOI:10.1038/s41401-024-01291-y (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Mo-Ting Liu Yao Zhang Cai-Gui Xiang Tao Yang Xiao-Han Wang Qiu-Kai Lu Hui-Min Lu Chen Fan Chun-Lan Feng Xiao-Qian Yang Duo-Wu Zou Heng Li Wei Tang Source Type: research
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
Acta Pharmacol Sin. 2024 Apr 29. doi: 10.1038/s41401-024-01273-0. Online ahead of print.NO ABSTRACTPMID:38684801 | DOI:10.1038/s41401-024-01273-0 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Xiao-Dan Guo Guang-Long Sun Ting-Ting Zhou Xin Xu Zhi-Yuan Zhu Vatcharin Rukachaisirikul Li-Hong Hu Xu Shen Source Type: research
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
Acta Pharmacol Sin. 2024 Apr 29. doi: 10.1038/s41401-024-01272-1. Online ahead of print.NO ABSTRACTPMID:38684802 | DOI:10.1038/s41401-024-01272-1 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Shi-Feng Chu Zhao Zhang Xin Zhou Wen-Bin He Chen Chen Piao Luo Dan-Dan Liu Qi-di Ai Hai-Fan Gong Zhen-Zhen Wang Hong-Shuo Sun Zhong-Ping Feng Nai-Hong Chen Source Type: research
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
Acta Pharmacologica Sinica, Published online: 29 April 2024; doi:10.1038/s41401-024-01291-yMethionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Mo-ting Liu Yao Zhang Cai-gui Xiang Tao Yang Xiao-han Wang Qiu-kai Lu Hui-min Lu Chen Fan Chun-lan Feng Xiao-qian Yang Duo-wu Zou Heng Li Wei Tang Source Type: research
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Acta Pharmacologica Sinica, Published online: 29 April 2024; doi:10.1038/s41401-024-01258-zBaicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Jian-qin Lai Le-le Zhao Chao Hong Qiu-ming Zou Jin-xuan Su Si-jia Li Xiao-feng Zhou Zi-sheng Li Bo Deng Jie Cao Qi Qi Source Type: research
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Acta Pharmacologica Sinica, Published online: 29 April 2024; doi:10.1038/s41401-024-01285-wKrüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Ana Beatriz Santos Andreia Carona Miren Ettcheto Antoni Camins Am ílcar Falcão Ana Fortuna Joana Bicker Source Type: research
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
Acta Pharmacologica Sinica, Published online: 29 April 2024; doi:10.1038/s41401-024-01273-0Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Xiao-dan Guo Guang-long Sun Ting-ting Zhou Xin Xu Zhi-yuan Zhu Vatcharin Rukachaisirikul Li-hong Hu Xu Shen Source Type: research
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
Acta Pharmacologica Sinica, Published online: 29 April 2024; doi:10.1038/s41401-024-01272-1Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Shi-feng Chu Zhao Zhang Xin Zhou Wen-bin He Chen Chen Piao Luo Dan-dan Liu Qi-di Ai Hai-fan Gong Zhen-zhen Wang Hong-shuo Sun Zhong-ping Feng Nai-hong Chen Source Type: research
Insomnia-related rodent models in drug discovery
Acta Pharmacol Sin. 2024 Apr 26. doi: 10.1038/s41401-024-01269-w. Online ahead of print.ABSTRACTDespite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is most likely due to relatively poor understanding of the etiology and pathophysiology of insomnia, and the lack of appropriate animal models for screening new compounds. As the main homeostatic, circadian, and neurochemical modulations of sleep remain essentially similar between humans and rodents, rodent models are often used to elucidate the mechanisms of insomnia and to develop nove...
Source: Acta Pharmacologica Sinica - April 26, 2024 Category: Drugs & Pharmacology Authors: Ze-Ka Chen Yuan-Yuan Liu Ji-Chuan Zhou Gui-Hai Chen Chun-Feng Liu Wei-Min Qu Zhi-Li Huang Source Type: research
Insomnia-related rodent models in drug discovery
Acta Pharmacol Sin. 2024 Apr 26. doi: 10.1038/s41401-024-01269-w. Online ahead of print.ABSTRACTDespite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is most likely due to relatively poor understanding of the etiology and pathophysiology of insomnia, and the lack of appropriate animal models for screening new compounds. As the main homeostatic, circadian, and neurochemical modulations of sleep remain essentially similar between humans and rodents, rodent models are often used to elucidate the mechanisms of insomnia and to develop nove...
Source: Acta Pharmacologica Sinica - April 26, 2024 Category: Drugs & Pharmacology Authors: Ze-Ka Chen Yuan-Yuan Liu Ji-Chuan Zhou Gui-Hai Chen Chun-Feng Liu Wei-Min Qu Zhi-Li Huang Source Type: research
Insomnia-related rodent models in drug discovery
Acta Pharmacol Sin. 2024 Apr 26. doi: 10.1038/s41401-024-01269-w. Online ahead of print.ABSTRACTDespite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is most likely due to relatively poor understanding of the etiology and pathophysiology of insomnia, and the lack of appropriate animal models for screening new compounds. As the main homeostatic, circadian, and neurochemical modulations of sleep remain essentially similar between humans and rodents, rodent models are often used to elucidate the mechanisms of insomnia and to develop nove...
Source: Acta Pharmacologica Sinica - April 26, 2024 Category: Drugs & Pharmacology Authors: Ze-Ka Chen Yuan-Yuan Liu Ji-Chuan Zhou Gui-Hai Chen Chun-Feng Liu Wei-Min Qu Zhi-Li Huang Source Type: research
