Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease
Adv Drug Deliv Rev. 2024 Apr 26:115321. doi: 10.1016/j.addr.2024.115321. Online ahead of print.ABSTRACTPosterior eye disorders, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, have a significant impact on human quality of life and are the primary cause of age-related retinal diseases among adults. There is a pressing need for innovative topical approaches to treat posterior eye disorders, as current methods often rely on invasive procedures with inherent risks. Limited success was attained in the realm of topical ophthalmic delivery through non-invasive means. Additionally, there exists a dear...
Source: Advanced Drug Delivery Reviews - April 28, 2024 Category: Drugs & Pharmacology Authors: Maria Jo ão Faria Jos é M González-Méijome M Elisabete C D Real Oliveira Gonzalo Carracedo Marlene L úcio Source Type: research
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease
Adv Drug Deliv Rev. 2024 Apr 26:115321. doi: 10.1016/j.addr.2024.115321. Online ahead of print.ABSTRACTPosterior eye disorders, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, have a significant impact on human quality of life and are the primary cause of age-related retinal diseases among adults. There is a pressing need for innovative topical approaches to treat posterior eye disorders, as current methods often rely on invasive procedures with inherent risks. Limited success was attained in the realm of topical ophthalmic delivery through non-invasive means. Additionally, there exists a dear...
Source: Advanced Drug Delivery Reviews - April 28, 2024 Category: Drugs & Pharmacology Authors: Maria Jo ão Faria Jos é M González-Méijome M Elisabete C D Real Oliveira Gonzalo Carracedo Marlene L úcio Source Type: research
Pharmaceutical and biotech industry perspectives on optimizing patient experience and treatment adherence through subcutaneous drug delivery design
Adv Drug Deliv Rev. 2024 Apr 25:115322. doi: 10.1016/j.addr.2024.115322. Online ahead of print.ABSTRACTSubcutaneous (SC) drug delivery can be a safe, effective alternative to the traditional intravenous route of administration, potentially offering notable advantages for both patients and healthcare providers. The SC Drug Development & Delivery Consortium convened in 2018 to raise awareness of industry challenges to advance the development of patient-centric SC drug delivery strategies. The SC Consortium identified better understanding of patient preferences and perspectives as necessary to optimize SC product design a...
Source: Advanced Drug Delivery Reviews - April 27, 2024 Category: Drugs & Pharmacology Authors: Jennifer Stevenson Rachel Poker Johanna Schoss Michael Campbell Claire Everitt Brian Holly Nicholas Stones Ronald J Pettis Manuel Sanchez-Felix Source Type: research
Advances in local drug delivery technologies for improved rheumatoid arthritis therapy
Adv Drug Deliv Rev. 2024 Apr 24;209:115325. doi: 10.1016/j.addr.2024.115325. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by an inflammatory microenvironment and cartilage erosion within the joint cavity. Currently, antirheumatic agents yield significant outcomes in RA treatment. However, their systemic administration is limited by inadequate drug retention in lesion areas and non-specific tissue distribution, reducing efficacy and increasing risks such as infection due to systemic immunosuppression. Development in local drug delivery technologies, such ...
Source: Advanced Drug Delivery Reviews - April 26, 2024 Category: Drugs & Pharmacology Authors: Xiaoran An Jiapei Yang Xiaolin Cui Jiaxuan Zhao Chenwei Jiang Minglu Tang Yabing Dong Longfei Lin Hui Li Feihu Wang Source Type: research
Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin
Adv Drug Deliv Rev. 2024 Apr 24:115315. doi: 10.1016/j.addr.2024.115315. Online ahead of print.ABSTRACTImmunotherapies have been transformative in many areas, including cancer treatments, allergies, and autoimmune diseases. However, significant challenges persist in extending the reach of these technologies to new indications and patients. Some of the major hurdles include narrow applicability to patient groups, transient efficacy, high cost burdens, poor immunogenicity, and side effects or off-target toxicity that results from lack of disease-specificity and inefficient delivery. Thus, there is a significant need for stra...
Source: Advanced Drug Delivery Reviews - April 26, 2024 Category: Drugs & Pharmacology Authors: Shrey A Shah Robert S Oakes Christopher M Jewell Source Type: research
Advances in local drug delivery technologies for improved rheumatoid arthritis therapy
Adv Drug Deliv Rev. 2024 Apr 24;209:115325. doi: 10.1016/j.addr.2024.115325. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by an inflammatory microenvironment and cartilage erosion within the joint cavity. Currently, antirheumatic agents yield significant outcomes in RA treatment. However, their systemic administration is limited by inadequate drug retention in lesion areas and non-specific tissue distribution, reducing efficacy and increasing risks such as infection due to systemic immunosuppression. Development in local drug delivery technologies, such ...
Source: Advanced Drug Delivery Reviews - April 26, 2024 Category: Drugs & Pharmacology Authors: Xiaoran An Jiapei Yang Xiaolin Cui Jiaxuan Zhao Chenwei Jiang Minglu Tang Yabing Dong Longfei Lin Hui Li Feihu Wang Source Type: research
Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin
Adv Drug Deliv Rev. 2024 Apr 24:115315. doi: 10.1016/j.addr.2024.115315. Online ahead of print.ABSTRACTImmunotherapies have been transformative in many areas, including cancer treatments, allergies, and autoimmune diseases. However, significant challenges persist in extending the reach of these technologies to new indications and patients. Some of the major hurdles include narrow applicability to patient groups, transient efficacy, high cost burdens, poor immunogenicity, and side effects or off-target toxicity that results from lack of disease-specificity and inefficient delivery. Thus, there is a significant need for stra...
Source: Advanced Drug Delivery Reviews - April 26, 2024 Category: Drugs & Pharmacology Authors: Shrey A Shah Robert S Oakes Christopher M Jewell Source Type: research
Nanoparticle-neutrophils interactions for autoimmune regulation
Adv Drug Deliv Rev. 2024 Apr 23:115316. doi: 10.1016/j.addr.2024.115316. Online ahead of print.ABSTRACTNeutrophils play an essential role as 'first responders' in the immune response, necessitating many immune-modulating capabilities. Chronic, unresolved inflammation is heavily implicated in the progression and tissue-degrading effects of autoimmune disease. Neutrophils modulate disease pathogenesis by interacting with the inflammatory and autoreactive cells through effector functions, including signaling, degranulation, and neutrophil extracellular traps (NETs) release. Since the current gold standard systemic glucocortic...
Source: Advanced Drug Delivery Reviews - April 25, 2024 Category: Drugs & Pharmacology Authors: Daniel Kupor Michael L Felder Shivanie Kodikalla Xueqi Chu Omolola Eniola-Adefeso Source Type: research
Nanomedicine biointeractions during body trafficking
Adv Drug Deliv Rev. 2024 Apr 23:115324. doi: 10.1016/j.addr.2024.115324. Online ahead of print.NO ABSTRACTPMID:38663551 | DOI:10.1016/j.addr.2024.115324 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 25, 2024 Category: Drugs & Pharmacology Authors: Wei He Huile Gao Wei Wu Source Type: research
Nanoparticle-neutrophils interactions for autoimmune regulation
Adv Drug Deliv Rev. 2024 Apr 23:115316. doi: 10.1016/j.addr.2024.115316. Online ahead of print.ABSTRACTNeutrophils play an essential role as 'first responders' in the immune response, necessitating many immune-modulating capabilities. Chronic, unresolved inflammation is heavily implicated in the progression and tissue-degrading effects of autoimmune disease. Neutrophils modulate disease pathogenesis by interacting with the inflammatory and autoreactive cells through effector functions, including signaling, degranulation, and neutrophil extracellular traps (NETs) release. Since the current gold standard systemic glucocortic...
Source: Advanced Drug Delivery Reviews - April 25, 2024 Category: Drugs & Pharmacology Authors: Daniel Kupor Michael L Felder Shivanie Kodikalla Xueqi Chu Omolola Eniola-Adefeso Source Type: research
Nanomedicine biointeractions during body trafficking
Adv Drug Deliv Rev. 2024 Apr 23:115324. doi: 10.1016/j.addr.2024.115324. Online ahead of print.NO ABSTRACTPMID:38663551 | DOI:10.1016/j.addr.2024.115324 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 25, 2024 Category: Drugs & Pharmacology Authors: Wei He Huile Gao Wei Wu Source Type: research
Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases
Adv Drug Deliv Rev. 2024 Apr 21:115323. doi: 10.1016/j.addr.2024.115323. Online ahead of print.ABSTRACTWith the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood-brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FU...
Source: Advanced Drug Delivery Reviews - April 23, 2024 Category: Drugs & Pharmacology Authors: Pengxuan Zhao Tiantian Wu Yu Tian Jia You Xinwu Cui Source Type: research
Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases
Adv Drug Deliv Rev. 2024 Apr 21:115323. doi: 10.1016/j.addr.2024.115323. Online ahead of print.ABSTRACTWith the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood-brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FU...
Source: Advanced Drug Delivery Reviews - April 23, 2024 Category: Drugs & Pharmacology Authors: Pengxuan Zhao Tiantian Wu Yu Tian Jia You Xinwu Cui Source Type: research
Fusobacterium nucleatum carcinogenesis and drug delivery interventions
This article presents a comprehensive review of microbial communities especially F. nucleatum in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated F. nucleatum is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.PMID:38643839 | DOI:10.1016/j.addr.2024.115319 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Zhenzhen Chen Leaf Huang Source Type: research
The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine
Adv Drug Deliv Rev. 2024 Apr 19:115318. doi: 10.1016/j.addr.2024.115318. Online ahead of print.ABSTRACTThe communication between cells and their microenvironment represents an intrinsic and essential attribute that takes place in several biological processes, including tissue homeostasis and tissue repair. Among these interactions, inflammation is certainly a central biological response that occurs through cytokines and the crosstalk with their respective receptors. In particular, the interaction between CCL2 and its main receptor, CCR2, plays a pivotal role in both harmful and protective inflammatory states, including can...
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Sabina Pozzi Ronit Satchi Fainaro Source Type: research
