Interventions to prevent and treat delirium: an umbrella review of randomized controlled trials
In conclusion, our work indicates that effective treatments to prevent delirium differ across populations, settings, and age groups. Results inform future guidelines to prevent or treat delirium, accounting for safety and costs of interventions. More research is needed in non-surgical settings.PMID:38677599 | DOI:10.1016/j.arr.2024.102313 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 27, 2024 Category: Genetics & Stem Cells Authors: Nicola Veronese Luisa Solimando Francesco Bolzetta Stefania Maggi Jess G Fiedorowicz Arnav Gupta Nicholas Fabiano Stanley Wong Laurent Boyer Guillaume Fond Elena Dragioti Ligia J Dominguez Mario Barbagallo Stefano Romagnoli Giuseppe Bellelli Marco Solmi Source Type: research
Senescence-Associated Secretory Phenotype (SASP) and Uterine Fibroids: Association with PD-L1 Activation and Collagen Deposition
Ageing Res Rev. 2024 Apr 24:102314. doi: 10.1016/j.arr.2024.102314. Online ahead of print.ABSTRACTUterine fibroids (or uterine leiomyoma, UFs) are one of the most prevalent benign uterine tumors with high proliferation and collagen synthesis capabilities. UFs are a significant worldwide health issue for women, affecting their physical and financial well-being. Risk factors for UFs include age, racial disparities, obesity, uterine infections, hormonal variation, and lifestyle (i.e., diet, exercise, stress, and smoking). Senescence and its associated secretory phenotypes (SASPs) are among the most salient changes accompanyin...
Source: Ageing Research Reviews - April 26, 2024 Category: Genetics & Stem Cells Authors: Eslam E Saad Rachel Michel Mostafa A Borahay Source Type: research
Towards prolonging ovarian reproductive life: Insights into trace elements homeostasis
Ageing Res Rev. 2024 Apr 16;97:102311. doi: 10.1016/j.arr.2024.102311. Online ahead of print.ABSTRACTOvarian aging is marked by a reduction in the quantity and quality of ovarian follicles, leading to a decline in female fertility and ovarian endocrine function. While the biological characteristics of ovarian aging are well-established, the exact mechanisms underlying this process remain elusive. Recent studies underscore the vital role of trace elements (TEs) in maintaining ovarian function. Imbalances in TEs can lead to ovarian aging, characterized by reduced enzyme activity, hormonal imbalances, ovulatory disorders, and...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Weicheng Tang Xiaoran Zhu Ying Chen Shuhong Yang Chuqing Wu Dan Chen Liru Xue Yican Guo Yun Dai Simin Wei Mingfu Wu Meng Wu Shixuan Wang Source Type: research
Aging as a loss of morphostatic information: A developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16;97:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecu...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: L éo Pio-Lopez Michael Levin Source Type: research
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
CONCLUSIONS: CST as delivered in adherence to the original 14-session protocol is an efficacious treatment for mild to moderate dementia with improvements in cognition, affective symptoms and quality of life demonstrated from global trials.PMID:38636561 | DOI:10.1016/j.arr.2024.102312 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Roopal Desai Wing Gi Leung Caroline Fearn Amber John Joshua Stott Aimee Spector Source Type: research
Towards Prolonging Ovarian Reproductive Life: Insights into Trace Elements Homeostasis
Ageing Res Rev. 2024 Apr 16:102311. doi: 10.1016/j.arr.2024.102311. Online ahead of print.ABSTRACTOvarian aging is marked by a reduction in the quantity and quality of ovarian follicles, leading to a decline in female fertility and ovarian endocrine function. While the biological characteristics of ovarian aging are well-established, the exact mechanisms underlying this process remain elusive. Recent studies underscore the vital role of trace elements (TEs) in maintaining ovarian function. Imbalances in TEs can lead to ovarian aging, characterized by reduced enzyme activity, hormonal imbalances, ovulatory disorders, and de...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Weicheng Tang Xiaoran Zhu Ying Chen Shuhong Yang Chuqing Wu Dan Chen Liru Xue Yican Guo Yun Dai Simin Wei Mingfu Wu Meng Wu Shixuan Wang Source Type: research
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: L éo Pio-Lopez Michael Levin Source Type: research
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
CONCLUSIONS: CST as delivered in adherence to the original 14-session protocol is an efficacious treatment for mild to moderate dementia with improvements in cognition, affective symptoms and quality of life demonstrated from global trials.PMID:38636561 | DOI:10.1016/j.arr.2024.102312 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Roopal Desai Wing Gi Leung Caroline Fearn Amber John Joshua Stott Aimee Spector Source Type: research
Towards Prolonging Ovarian Reproductive Life: Insights into Trace Elements Homeostasis
Ageing Res Rev. 2024 Apr 16:102311. doi: 10.1016/j.arr.2024.102311. Online ahead of print.ABSTRACTOvarian aging is marked by a reduction in the quantity and quality of ovarian follicles, leading to a decline in female fertility and ovarian endocrine function. While the biological characteristics of ovarian aging are well-established, the exact mechanisms underlying this process remain elusive. Recent studies underscore the vital role of trace elements (TEs) in maintaining ovarian function. Imbalances in TEs can lead to ovarian aging, characterized by reduced enzyme activity, hormonal imbalances, ovulatory disorders, and de...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Weicheng Tang Xiaoran Zhu Ying Chen Shuhong Yang Chuqing Wu Dan Chen Liru Xue Yican Guo Yun Dai Simin Wei Mingfu Wu Meng Wu Shixuan Wang Source Type: research
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: L éo Pio-Lopez Michael Levin Source Type: research
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
CONCLUSIONS: CST as delivered in adherence to the original 14-session protocol is an efficacious treatment for mild to moderate dementia with improvements in cognition, affective symptoms and quality of life demonstrated from global trials.PMID:38636561 | DOI:10.1016/j.arr.2024.102312 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Roopal Desai Wing Gi Leung Caroline Fearn Amber John Joshua Stott Aimee Spector Source Type: research
Towards Prolonging Ovarian Reproductive Life: Insights into Trace Elements Homeostasis
Ageing Res Rev. 2024 Apr 16:102311. doi: 10.1016/j.arr.2024.102311. Online ahead of print.ABSTRACTOvarian aging is marked by a reduction in the quantity and quality of ovarian follicles, leading to a decline in female fertility and ovarian endocrine function. While the biological characteristics of ovarian aging are well-established, the exact mechanisms underlying this process remain elusive. Recent studies underscore the vital role of trace elements (TEs) in maintaining ovarian function. Imbalances in TEs can lead to ovarian aging, characterized by reduced enzyme activity, hormonal imbalances, ovulatory disorders, and de...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Weicheng Tang Xiaoran Zhu Ying Chen Shuhong Yang Chuqing Wu Dan Chen Liru Xue Yican Guo Yun Dai Simin Wei Mingfu Wu Meng Wu Shixuan Wang Source Type: research
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: L éo Pio-Lopez Michael Levin Source Type: research
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
CONCLUSIONS: CST as delivered in adherence to the original 14-session protocol is an efficacious treatment for mild to moderate dementia with improvements in cognition, affective symptoms and quality of life demonstrated from global trials.PMID:38636561 | DOI:10.1016/j.arr.2024.102312 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Roopal Desai Wing Gi Leung Caroline Fearn Amber John Joshua Stott Aimee Spector Source Type: research
The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?
Ageing Res Rev. 2024 Apr 12;97:102308. doi: 10.1016/j.arr.2024.102308. Online ahead of print.ABSTRACTAging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a considerable economic burden on individuals and society. The development of age-related ocular disease is predominantly triggered by oxidative stress and chronic inflammatory reaction. Heme oxygenase-1 (HO-1) is a crucial antioxidant t...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Dong Wei Chengkang Qu Na Zhao Siyu Li Ning Pu Zongming Song Ye Tao Source Type: research
