EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma
Aging (Albany NY). 2024 Apr 29;16. doi: 10.18632/aging.205759. Online ahead of print.ABSTRACTCholangiocarcinoma, a prevalent hepatic malignancy, exhibits a progressively rising incidence. While Eukaryotic translation initiation factor 3 subunit B (EIF3B) has been implicated in the occurrence and development of various cancers, its specific roles in cholangiocarcinoma remain unexplored. Immunohistochemical (IHC) analysis was employed to detect EIF3B/PCNA expression in cholangiocarcinoma. Cells were manipulated using short hairpin RNA (shRNA)-mediated lentiviruses or overexpression plasmids. Statistical significance was asse...
Source: Aging - April 30, 2024 Category: Biomedical Science Authors: Ranglang Huang Wanpin Nie Liangliang Mi Chenjiao Yao Haixia Zhu Source Type: research
HCMMD: systematic evaluation of metabolites in body fluids as liquid biopsy biomarker for human cancers
In conclusion, HCMMD provides an important resource to assist researchers in reviewing metabolic biomarkers for diagnosis and progression of cancers.PMID:38683118 | DOI:10.18632/aging.205779 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Xun Dong Yaoyao Qu Tongtong Sheng Yuanming Fan Silu Chen Qinbo Yuan Gaoxiang Ma Yuqiu Ge Source Type: research
Iron retardation in lysosome protects senescent cells from ferroptosis
Aging (Albany NY). 2024 Apr 26;16. doi: 10.18632/aging.205777. Online ahead of print.ABSTRACTFerroptosis, an iron-triggered modality of cellular death, has been reported to closely relate to human aging progression and aging-related diseases. However, the involvement of ferroptosis in the development and maintenance of senescent cells still remains elusive. Here, we established a doxorubicin-induced senescent HSkM cell model and found that both iron accumulation and lipid peroxidation increase in senescent cells. Moreover, such iron overload in senescent cells has changed the expression panel of the ferroptosis-response pr...
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Yujing Feng Huaiqing Wei Meng Lyu Zhiyuan Yu Jia Chen Xinxing Lyu Fengfeng Zhuang Source Type: research
Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure
CONCLUSIONS: In this study, where senescence was induced by UV-A, a more physiological stress for hCEnCs compared to IR, we determined that UV-A modulated the expression of many genes and proteins typically altered upon IR treatment, a more conventional method of senescence induction, even though UV-A also modulated specific pathways unrelated to IR.PMID:38683123 | DOI:10.18632/aging.205761 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Kohsaku Numa Sandip Kumar Patel Zhixin A Zhang Jordan B Burton Akifumi Matsumoto Jun-Wei B Hughes Chie Sotozono Birgit Schilling Pierre-Yves Desprez Judith Campisi Koji Kitazawa Source Type: research
Causal association of metformin treatment with diverse cardiovascular diseases: a Mendelian randomization analysis
CONCLUSION: The MR study discovered from a genetic standpoint that metformin may lower the risk of hypertrophic cardiomyopathy and valvular heart disease, yet it could elevate the risk of myocardial infarction.PMID:38683129 | DOI:10.18632/aging.205775 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Kaiyuan Li Peng Liu Jun Ye Miao Liu Li Zhu Source Type: research
Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transformation
CONCLUSION: This study elucidates the potential molecular mechanisms underlying the occurrence of LM from various angles through single-cell multi-omics analysis in CRC. It also constructs a network illustrating the role of senescent or exhausted immune cells in regulating EMT.PMID:38683136 | DOI:10.18632/aging.205778 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Sen Lin Lanyue Ma Jiaxin Mo Ruiqi Zhao Jinghao Li Mengjiao Yu Mei Jiang Lisheng Peng Source Type: research
Exploring causality in the association between gut microbiota and irritable bowel syndrome risk: a large Mendelian randomization study
CONCLUSIONS: This study presented novel insights that highlighted the causal relationship between gut microbiota and IBS, and offered new treatment strategies for preventing or treating IBS.PMID:38669090 | DOI:10.18632/aging.205771 (Source: Aging)
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Jishi Zhang Xinlin Shi Yun Wang Source Type: research
Establishment and assessment of mortality risk prediction model in patients with sepsis based on early-stage peripheral lymphocyte subsets
This study is aimed to explore the value of lymphocyte subsets in evaluating the severity and prognosis of sepsis. The counts of lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, and NK cells significantly decreased between day 1 and day 3 in both the survivor and the non-survivor groups. The peripheral lymphocyte subsets (PLS) at day 1 were not significantly different between the survivor and the non-survivor groups. However, at day 3, the counts of lymphocytes, CD3+ T cells, CD4+ T cells, and NK cells were remarkably lower in the non-survivor group. No significant differences in CD8+ T cells, or CD19+...
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Fuzhu Li Hongtao Qu Yimin Li Jie Liu Hongyun Fu Source Type: research
Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1
Aging (Albany NY). 2024 Apr 25;16. doi: 10.18632/aging.205750. Online ahead of print.ABSTRACTGlioma is the most frequently diagnosed primary brain tumor and typically has a poor prognosis because of malignant proliferation and invasion. It is urgent to elucidate the mechanisms driving glioma tumorigenesis and develop novel treatments to address this deadly disease. Here, we first revealed that PDZK1 is expressed at high levels in gliomas. Promoter hypomethylation may cause high expression of PDZK1 in glioma. Knockdown of PDZK1 inhibits glioma cell proliferation and invasion in vitro. Mechanistically, further investigations...
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Xing Ren Dan Deng Shasha Xiang Jianbo Feng Source Type: research
Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification
In conclusion, ROS-induced autophagy is closely related to mTOR, SIRT1 and others, and X5 holds promise as a candidate for the treatment of CIRI.PMID:38669115 | DOI:10.18632/aging.205773 (Source: Aging)
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Yuantie Zheng Zhicheng Huang Yang Zhao Lili Huang Jun Wang Heping Li Xing Chen Jingsong Wang Jingwen Xie Source Type: research
Exploring causality in the association between gut microbiota and irritable bowel syndrome risk: a large Mendelian randomization study
CONCLUSIONS: This study presented novel insights that highlighted the causal relationship between gut microbiota and IBS, and offered new treatment strategies for preventing or treating IBS.PMID:38669090 | DOI:10.18632/aging.205771 (Source: Aging)
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Jishi Zhang Xinlin Shi Yun Wang Source Type: research
Establishment and assessment of mortality risk prediction model in patients with sepsis based on early-stage peripheral lymphocyte subsets
This study is aimed to explore the value of lymphocyte subsets in evaluating the severity and prognosis of sepsis. The counts of lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, and NK cells significantly decreased between day 1 and day 3 in both the survivor and the non-survivor groups. The peripheral lymphocyte subsets (PLS) at day 1 were not significantly different between the survivor and the non-survivor groups. However, at day 3, the counts of lymphocytes, CD3+ T cells, CD4+ T cells, and NK cells were remarkably lower in the non-survivor group. No significant differences in CD8+ T cells, or CD19+...
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Fuzhu Li Hongtao Qu Yimin Li Jie Liu Hongyun Fu Source Type: research
Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1
Aging (Albany NY). 2024 Apr 25;16. doi: 10.18632/aging.205750. Online ahead of print.ABSTRACTGlioma is the most frequently diagnosed primary brain tumor and typically has a poor prognosis because of malignant proliferation and invasion. It is urgent to elucidate the mechanisms driving glioma tumorigenesis and develop novel treatments to address this deadly disease. Here, we first revealed that PDZK1 is expressed at high levels in gliomas. Promoter hypomethylation may cause high expression of PDZK1 in glioma. Knockdown of PDZK1 inhibits glioma cell proliferation and invasion in vitro. Mechanistically, further investigations...
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Xing Ren Dan Deng Shasha Xiang Jianbo Feng Source Type: research
Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification
In conclusion, ROS-induced autophagy is closely related to mTOR, SIRT1 and others, and X5 holds promise as a candidate for the treatment of CIRI.PMID:38669115 | DOI:10.18632/aging.205773 (Source: Aging)
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Yuantie Zheng Zhicheng Huang Yang Zhao Lili Huang Jun Wang Heping Li Xing Chen Jingsong Wang Jingwen Xie Source Type: research
Exploring causality in the association between gut microbiota and irritable bowel syndrome risk: a large Mendelian randomization study
CONCLUSIONS: This study presented novel insights that highlighted the causal relationship between gut microbiota and IBS, and offered new treatment strategies for preventing or treating IBS.PMID:38669090 | DOI:10.18632/aging.205771 (Source: Aging)
Source: Aging - April 26, 2024 Category: Biomedical Science Authors: Jishi Zhang Xinlin Shi Yun Wang Source Type: research
