SGLT2 inhibitors: not every drug has the same effect
Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00126.2024. Online ahead of print.NO ABSTRACTPMID:38695073 | DOI:10.1152/ajprenal.00126.2024 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Alexander Staruschenko Source Type: research
Kidney collecting-duct-derived vasopressin is not essential for appropriate concentration or dilution of urine
Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00057.2024. Online ahead of print.ABSTRACTWe previously showed that kidney collecting ducts make vasopressin. However, the physiologic role of collecting-duct-derived vasopressin is uncertain. We hypothesized that collecting-duct-derived vasopressin was required for appropriate concentration of urine. We developed a vasopressin conditional knockout mouse model wherein Cre recombinase expression induces deletion of Avp exon 1 in the distal nephron. We then used age-matched 8 - 12 week old Avp fl/fl;Ksp-Cre(-) (WT) and Avp fl/fl;Ksp-Cre(+) mice for all experiments...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Yvonne Zuchowski Joshua Carty Jonathan B Trapani Jason Watts Fabian Bock Mingzhi Zhang Andrew Terker Roy Zent Eric Delpire Raymond C Harris Juan Pablo Arroyo Source Type: research
Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy
In this study, the preventive effects of the VASH2-targeting peptide vaccine against glomerular injury were examined in a streptozotocin (STZ)-induced diabetic mouse model. The mice were subcutaneously injected with the vaccine at two doses 2 weeks apart and then intraperitoneally injected with 50 mg/kg STZ for 5 consecutive days. Glomerular injury was evaluated 20 weeks after the first vaccination. Treatment with the VASH2-targeting peptide vaccine successfully induced circulating anti-VASH2 antibody without inflammation in major organs. Although the vaccination did not affect blood glucose levels, it significantly preven...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Yuri Nakashima Katsuyuki Tanabe Tomoyo Mifune Takato Nakadoi Hiroki Hayashi Hironori Nakagami Yasufumi Sato Jun Wada Source Type: research
Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury
In this study we show in vitro and in vivo that Park7 has a crucial role in protection from AKI, and upregulated peroxisome activity. These data in combination with published results of Park7's protective role in cardiovascular damage and chronic kidney disease lead us to hypothesize that succinylation of Park7 may ameliorate oxidative damage resulting from AKI and prevent disease progression. This novel mechanism provides a potential therapeutic mechanism that can be targeted.PMID:38695076 | DOI:10.1152/ajprenal.00062.2024 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Katherine Pfister Victoria Young Brendon Frankel Anne Silva Barbosa Jordan Burton Joanna Bons Bob Zhang Takuto Chiba Rebecca Uhlean Eric Goetzman Birgit Schilling Sunder Sims-Lucas Source Type: research
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease
Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00383.2023. Online ahead of print.ABSTRACTAccording to the Developmental Origins of Health and Disease (DOHaD) hypothesis, exposure to certain environmental influences during early life may be a key determinant of fetal development and short- and long-term offspring health. Indeed, adverse conditions encountered during the fetal, perinatal, and early childhood stages can alter normal development and growth, as well as put the offspring at elevated risk of developing long-term health conditions in adulthood, including chronic kidney disease (CKD) and cardiovascul...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Zo é Oulerich Amanda N Sferruzzi-Perri Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Cell death induced by acute kidney injury: A perspective on the contributions of accidental and programmed cell death
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00275.2023. Online ahead of print.ABSTRACTThe involvement of cell death in AKI is linked to multiple factors including nucleotide depletion, electrolyte imbalance, reactive oxygen species, endonucleases, disturbance of mitochondrial integrity, and activation of several cell death pathway components. Since our review in 2003, discussing the relative contributions of apoptosis and necrosis, several other forms of cell death have been identified and are shown to contribute to acute kidney injury (AKI). Currently, these various forms of cell death can be fundamenta...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Mi Ra Noh Babu J Padanilam Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Cell death induced by acute kidney injury: A perspective on the contributions of accidental and programmed cell death
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00275.2023. Online ahead of print.ABSTRACTThe involvement of cell death in AKI is linked to multiple factors including nucleotide depletion, electrolyte imbalance, reactive oxygen species, endonucleases, disturbance of mitochondrial integrity, and activation of several cell death pathway components. Since our review in 2003, discussing the relative contributions of apoptosis and necrosis, several other forms of cell death have been identified and are shown to contribute to acute kidney injury (AKI). Currently, these various forms of cell death can be fundamenta...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Mi Ra Noh Babu J Padanilam Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Cell death induced by acute kidney injury: A perspective on the contributions of accidental and programmed cell death
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00275.2023. Online ahead of print.ABSTRACTThe involvement of cell death in AKI is linked to multiple factors including nucleotide depletion, electrolyte imbalance, reactive oxygen species, endonucleases, disturbance of mitochondrial integrity, and activation of several cell death pathway components. Since our review in 2003, discussing the relative contributions of apoptosis and necrosis, several other forms of cell death have been identified and are shown to contribute to acute kidney injury (AKI). Currently, these various forms of cell death can be fundamenta...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Mi Ra Noh Babu J Padanilam Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
