American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis
Am J Physiol Endocrinol Metab. 2024 May 1. doi: 10.1152/ajpendo.00069.2024. Online ahead of print.ABSTRACTPancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate which controls hormone release and β-cell viability by acting on glutamate receptors expressed by endocrine cells. We here investigate whether alteration of the Excitatory Amino Acid Transporter 2 (EAAT2), the major glutamate clearance system in the islet, may occur in type 2 diabetes mellitus (T2DM) and contribute to β-cell dysfunction. Increased EAAT2 intracellular localiz...
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Alessandra Galli Stefania Moretti Nevia Dule Eliana Sara Di Cairano Michela Castagna Paola Marciani Cristina Battaglia Federico Bertuzzi Ida Pastore Paolo Fiorina Stefano La Rosa Alberto Davalli Franco Folli Carla Perego Source Type: research

NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration
CONCLUSION: These data indicate that supraphysiological levels of Testo increase the endothelial expression and activity of NOX4 to counterbalance the deleterious effects caused by Testo in endothelial function.PMID:38690939 | DOI:10.1152/ajpendo.00365.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Juliano V Alves Rafael M da Costa Wanessa M C Awata Ariane Bruder-Nascimento Shubhnita Singh Rita C Tostes Thiago Bruder-Nascimento Source Type: research

Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00013.2024. Online ahead of print.ABSTRACTFatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed quantitative proteomics in lean, glucose-tolerant mice compared to high-fat diet (HFD) fed mice that displayed hepatic steatosis and glucose intolerance as well as high-starch diet (HStD) fed mice who exhibited similar levels of hepatic steatosis but remained glucose tolerant. Both HFD and HStD-fed mice had more and larger LDs t...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Andries Van Woerkom Dylan J Harney Shilpa R Nagarajan Mariam F Hakeem-Sanni Jinfeng Lin Matthew Hooke Tamara Pilpitel Gregory J Cooney Mark Larance Darren N Saunders Amanda E Brandon Andrew J Hoy Source Type: research

Chronic Pancreatitis-Associated Metabolic Bone Diseases: Epidemiology, Mechanisms, and Clinical Advances
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00113.2024. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a progressive inflammatory disease with an increasing global prevalence. In recent years, a strong association between CP and metabolic bone diseases (MBDs), especially osteoporosis, has been identified, attracting significant attentions in the research field. Epidemiological data suggest a rising trend in the incidence of MBDs among CP patients. Notably, recent studies have highlighted a profound interplay between CP and altered nutritional and immune profiles, offering insights into its ...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Tianlin Wang Ke Xiong Yanli He Binbin Feng Linbin Guo Jingliang Gu Hong Wang Xiaohao Wu Source Type: research

< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research

Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research