American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Activation of the non-neuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury
CONCLUSION: Activation of the NNCCS is involved in cardiomyocyte protection: HPC increases intra- and extracellular ACh during H/R, and m-/nAChRs are causally involved in HPC´s cardiomyocyte protection during H/R. The interplay between upstream ICNS activation and the NNCCS activation to myocardial cholinergic metabolism and cardioprotection needs to be investigated in future studies.PMID:38700468 | DOI:10.1152/ajpheart.00211.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Felix Braczko Sara Romina Fischl J örg Reinders Helmut Raphael Lieder Petra Kleinbongard Source Type: research

Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00020.2024. Online ahead of print.ABSTRACTPreeclampsia is a risk factor for future cardiovascular diseases. However, the mechanisms underlying this association remain unclear, limiting effective prevention strategies. Blood pressure responses to acute stimuli may reveal cardiovascular dysfunction not apparent at rest, identifying individuals at elevated cardiovascular risk. Therefore, we compared blood pressure responsiveness to acute stimuli between previously preeclamptic (PPE) women (34±5yr, 13±6 months postpartum) and women following healthy pregnanci...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Danielle E Berbrier Tessa E Adler Cheryl A Leone Michael J Paidas Nina S Stachenfeld Charlotte W Usselman Source Type: research

Isoproterenol Improves Hemodynamics And Right Ventricle-Pulmonary Artery Coupling After Heart Transplantation
CONCLUSIONS: In post-HT RVF, isoproterenol exhibits chronotropic and inotropic effects, thereby improving RV-PA coupling and resulting in a clinically relevant increase in the cardiac index.PMID:38700470 | DOI:10.1152/ajpheart.00200.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: David Levy Ouriel Saura Manuela Lucenteforte Elena Collado Lled ó Pierre Demondion Nadjib Hammoudi Benjamin Assouline Matthieu Petit Melchior Gautier Lucie Le Fevre Marc Pineton de Chambrun Guillaume Coutance Elodie Berg Juliette Chommeloux Matthieu Schm Source Type: research

Effects of Acute Hyperoxia on Autonomic Function and Coronary Tone in Patients with Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00225.2024. Online ahead of print.ABSTRACTNumerous studies have shown that oxidative stress plays an important role in peripheral artery disease (PAD). Prior reports suggested autonomic dysfunction in PAD. We hypothesized that responses of the autonomic nervous system and coronary tone would be impaired in patients with PAD during exposure to acute hyperoxia, an oxidative stressor. In 20 PAD patients and 16 healthy, sex and age-matched controls, beat-by-beat heart rate (HR, from ECG) and blood pressure (BP, with Finometer) were recorded for 10 minutes durin...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Mami Hamaoka Urs A Leuenberger Zhaohui Gao Faisal Aziz Danielle Jin-Kwang Kim Jonathan Carter Luck Cheryl Blaha Aimee E Cauffman Lawrence I Sinoway Jian Cui Source Type: research

Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00133.2024. Online ahead of print.ABSTRACTIntense inspiratory muscle work can evoke a metabolite stimulated pressor reflex, commonly referred to as the respiratory muscle metaboreflex. When completing similar relative and absolute levels of inspiratory work, females have an attenuated blood pressure response. We sought to test the hypothesis that the lower blood pressure response to the respiratory muscle metaboreflex in females is associated with a reduced sympathetic response. Healthy young (26±4 y) males (n=9) and females (n=7) completed two experimenta...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Michael G Leahy Stephen A Busch Scott F Thrall Sam J Hillen A William Sheel Glen E Foster Source Type: research

Perspective on statistical power and equivalences tests
Am J Physiol Heart Circ Physiol. 2024 May 3. doi: 10.1152/ajpheart.00746.2023. Online ahead of print.ABSTRACTThe use of both sexes or genders should be considered in experimental design, analysis, and reporting. Since there is no requirement to double the sample size or to have sufficient power to study sex differences, challenges for the statistical analysis can arise. In this article we focus on the topics of statistical power and ways to increase this power. We also discuss the choice of an appropriate design and statistical method, and include a separate section on equivalence tests needed to show the absence of a rele...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Markus Neuh äuser Graeme D Ruxton Source Type: research

Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction
CONCLUSIONS: Acute sympathoexcitation caused exaggerated peripheral vasoconstriction and reduced peripheral blood flow in patients with HFrEF. Handgrip exercise abolished sympathoexcitatory-mediated peripheral vasoconstriction and normalized peripheral blood flow in patients with HFrEF. These novel data reveal intact functional sympatholysis in the upper limb and suggest exercise-mediated, local control of blood flow is preserved when cardiac limitations that are cardinal to HFrEF are evaded with dynamic handgrip exercise.PMID:38700474 | DOI:10.1152/ajpheart.00130.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Natasha G Boyes M Rafique Khan Adam M S Luchkanych Rory A Marshall Idris Bare Tony Haddad Sherif Abdalla Ibrahim Al-Mouaiad Al-Azem Cameron J Morse Alexander Zhai Haissam Haddad Darcy D Marciniuk T Dylan Olver Corey R Tomczak Source Type: research

Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart
CONCLUSION: There is dynamic regulation of ER proteostasis, ER stress, and the apoptosis cascade in the perinatal heart. Apoptotic signaling is more readily activated in fetal cardiomyocytes near birth, leading to widespread caspase cleavage in the newborn heart. These pathways are important for regulation of normal maturation in the healthy perinatal heart.PMID:38700493 | DOI:10.1152/ajpheart.00043.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 3, 2024 Category: Physiology Authors: Karthikeyan Bose Herbert M Espinoza Samantha Louey Sonnet S Jonker Source Type: research

Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period
In this study, we evaluated whether this model could capture heart growth beyond normal pregnancy. After further validation of our normal pregnancy predictions, we tested our model predictions of three rat studies of hypertensive pregnancies. Next, we simulated the postpartum period and examined the impact of lactation on cardiac growth in rats. We demonstrate that our multiscale model can capture cardiac growth associated with new-onset hypertension during pregnancy and lactation status in the postpartum period. We conclude by elaborating on the potential clinical utility of our model in the future.PMID:38668702 | DOI:10....
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Molly S Kaissar Kyoko Yoshida Source Type: research

Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis
Am J Physiol Heart Circ Physiol. 2024 Apr 26. doi: 10.1152/ajpheart.00052.2024. Online ahead of print.ABSTRACTFetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency-induced FGR offspring. We included 6 animal and 49 human studies. While unable to perform a meta-analysis of animal studies due to insufficient number of stu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Mette van de Meent Kirsten T Nijholt Shary C A Joemmanbaks Judith Kooiman Henk S Schipper Kim E Wever A Titia Lely Fieke Terstappen Source Type: research

Modeling heart failure with preserved ejection fraction in female mice: an elusive target
Am J Physiol Heart Circ Physiol. 2024 Apr 26. doi: 10.1152/ajpheart.00139.2024. Online ahead of print.NO ABSTRACTPMID:38668704 | DOI:10.1152/ajpheart.00139.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Taben M Hale Erik A Blackwood Source Type: research