American Journal of Physiology. Regulatory, Integrative and Comparative Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Interactive effects of exercise intensity and recovery posture on post-exercise hypotension
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 22. doi: 10.1152/ajpregu.00036.2024. Online ahead of print.ABSTRACTPost-exercise reduction in blood pressure, termed post-exercise hypotension (PEH), is relevant for both acute and chronic health reasons and potentially for peripheral cardiovascular adaptations. We investigated the interactive effects of exercise intensity and recovery postures (seated, supine, and standing) on PEH. Thirteen normotensive men underwent a VO2max test on a cycle ergometer and 5 exhaustive constant load trials to determine critical power (CP) and the gas exchange threshold (GET). Subsequently, w...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 22, 2024 Category: Physiology Authors: Xueer Lu Richie Philip Goulding Toby Mundel Zachary J Schlader James D Cotter Shunsaku Koga Naoto Fujii I-Lin Wang Ziyang Liu Hao-Yu Li Hui Wang Huixin Zheng Narihiko Kondo Chin-Yi Gu Tze-Huan Lei Faming Wang Source Type: research

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research

ß-cell selective regulation of gene expression by nitric oxide
In this report, the time- and concentration-dependent effects of nitric oxide on the expression of 6 genes known to participate in the response of β-cells to this free radical were examined. The genes included Gadd45α (DNA repair), Puma (apoptosis), Hmox1 (antioxidant defense), Hsp70 (heat shock), Chop (UPR), and ßPpargc1α (mitochondrial biogenesis). We show that nitric oxide stimulates β-cell gene expression in a narrow concentration range of ~0.5-1 µM, or levels corresponding to iNOS-derived nitric oxide. At concentrations greater than 1 µM, nitric oxide fails to stimulate gene expression in β-cells, and this is ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 8, 2024 Category: Physiology Authors: Aaron Naatz Chay Teng Yeo Neil Hogg John A Corbett Source Type: research

Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and pre-surgery body weight
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 8. doi: 10.1152/ajpregu.00169.2023. Online ahead of print.ABSTRACTDiets varying in macronutrient composition, energy density, and/or palatability may cause differences in outcome of bariatric surgery. In the present study, rats feeding a healthy low fat (LF) diet or an obesogenic high fat/sucrose diet (HF/S) were either subjected to Roux-en-Y gastric bypass surgery (RYGB) or sham surgery, and weight loss trajectories and various energy balance parameters were assessed. Before RYGB, rats eating a HF/S (n=14) diet increased body weight relative to rats eating a LF diet (n=20; ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 8, 2024 Category: Physiology Authors: C Warner Hoornenborg Edit Somogyi Jan E Bruggink Christina N Boyle Thomas A Lutz Marloes Emous Andr é P van Beek Csaba Nyakas Gertjan van Dijk Source Type: research