Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model
Ann Biomed Eng. 2024 May 3. doi: 10.1007/s10439-024-03520-1. Online ahead of print.ABSTRACTMultiscale agent-based modeling frameworks have recently emerged as promising mechanobiological models to capture the interplay between biomechanical forces, cellular behavior, and molecular pathways underlying restenosis following percutaneous transluminal angioplasty (PTA). However, their applications are mainly limited to idealized scenarios. Herein, a multiscale agent-based modeling framework for investigating restenosis following PTA in a patient-specific superficial femoral artery (SFA) is proposed. The framework replicates the...
Source: Annals of Biomedical Engineering - May 3, 2024 Category: Biomedical Engineering Authors: Anna Corti Matilde Marradi Cemre Çelikbudak Orhon Francesca Boccafoschi Philippe B üchler Jose F Rodriguez Matas Claudio Chiastra Source Type: research
Parotid Gland Segmentation Using Purely Transformer-Based U-Shaped Network and Multimodal MRI
Ann Biomed Eng. 2024 May 1. doi: 10.1007/s10439-024-03510-3. Online ahead of print.ABSTRACTParotid gland tumors account for approximately 2% to 10% of head and neck tumors. Segmentation of parotid glands and tumors on magnetic resonance images is essential in accurately diagnosing and selecting appropriate surgical plans. However, segmentation of parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently, deep learning has developed rapidly, and Transformer-based networks have performed well on many computer vision tasks. However, Transformer-based networks...
Source: Annals of Biomedical Engineering - May 1, 2024 Category: Biomedical Engineering Authors: Zi'an Xu Yin Dai Fayu Liu Siqi Li Sheng Liu Lifu Shi Jun Fu Source Type: research
Parotid Gland Segmentation Using Purely Transformer-Based U-Shaped Network and Multimodal MRI
Ann Biomed Eng. 2024 May 1. doi: 10.1007/s10439-024-03510-3. Online ahead of print.ABSTRACTParotid gland tumors account for approximately 2% to 10% of head and neck tumors. Segmentation of parotid glands and tumors on magnetic resonance images is essential in accurately diagnosing and selecting appropriate surgical plans. However, segmentation of parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently, deep learning has developed rapidly, and Transformer-based networks have performed well on many computer vision tasks. However, Transformer-based networks...
Source: Annals of Biomedical Engineering - May 1, 2024 Category: Biomedical Engineering Authors: Zi'an Xu Yin Dai Fayu Liu Siqi Li Sheng Liu Lifu Shi Jun Fu Source Type: research
Parotid Gland Segmentation Using Purely Transformer-Based U-Shaped Network and Multimodal MRI
Ann Biomed Eng. 2024 May 1. doi: 10.1007/s10439-024-03510-3. Online ahead of print.ABSTRACTParotid gland tumors account for approximately 2% to 10% of head and neck tumors. Segmentation of parotid glands and tumors on magnetic resonance images is essential in accurately diagnosing and selecting appropriate surgical plans. However, segmentation of parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently, deep learning has developed rapidly, and Transformer-based networks have performed well on many computer vision tasks. However, Transformer-based networks...
Source: Annals of Biomedical Engineering - May 1, 2024 Category: Biomedical Engineering Authors: Zi'an Xu Yin Dai Fayu Liu Siqi Li Sheng Liu Lifu Shi Jun Fu Source Type: research
Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential
Ann Biomed Eng. 2024 Apr 29. doi: 10.1007/s10439-024-03523-y. Online ahead of print.ABSTRACTUltrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, m...
Source: Annals of Biomedical Engineering - April 29, 2024 Category: Biomedical Engineering Authors: Wenxin Liang Beibei Liang Kaicheng Yan Guanxuanzi Zhang Jiaju Zhuo Yun Cai Source Type: research
Controlled Mechanical Property Gradients Within a Digital Light Processing Printed Hydrogel-Composite Osteochondral Scaffold
Ann Biomed Eng. 2024 Apr 29. doi: 10.1007/s10439-024-03516-x. Online ahead of print.ABSTRACTTissue engineered scaffolds are needed to support physiological loads and emulate the micrometer-scale strain gradients within tissues that guide cell mechanobiological responses. We designed and fabricated micro-truss structures to possess spatially varying geometry and controlled stiffness gradients. Using a custom projection microstereolithography (μSLA) system, using digital light projection (DLP), and photopolymerizable poly(ethylene glycol) diacrylate (PEGDA) hydrogel monomers, three designs with feature sizes < 200 μm we...
Source: Annals of Biomedical Engineering - April 29, 2024 Category: Biomedical Engineering Authors: Kevin N Eckstein John E Hergert Asais Camila Uzcategui Sarah A Schoonraad Stephanie J Bryant Robert R McLeod Virginia L Ferguson Source Type: research
Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential
Ann Biomed Eng. 2024 Apr 29. doi: 10.1007/s10439-024-03523-y. Online ahead of print.ABSTRACTUltrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, m...
Source: Annals of Biomedical Engineering - April 29, 2024 Category: Biomedical Engineering Authors: Wenxin Liang Beibei Liang Kaicheng Yan Guanxuanzi Zhang Jiaju Zhuo Yun Cai Source Type: research
Controlled Mechanical Property Gradients Within a Digital Light Processing Printed Hydrogel-Composite Osteochondral Scaffold
Ann Biomed Eng. 2024 Apr 29. doi: 10.1007/s10439-024-03516-x. Online ahead of print.ABSTRACTTissue engineered scaffolds are needed to support physiological loads and emulate the micrometer-scale strain gradients within tissues that guide cell mechanobiological responses. We designed and fabricated micro-truss structures to possess spatially varying geometry and controlled stiffness gradients. Using a custom projection microstereolithography (μSLA) system, using digital light projection (DLP), and photopolymerizable poly(ethylene glycol) diacrylate (PEGDA) hydrogel monomers, three designs with feature sizes < 200 μm we...
Source: Annals of Biomedical Engineering - April 29, 2024 Category: Biomedical Engineering Authors: Kevin N Eckstein John E Hergert Asais Camila Uzcategui Sarah A Schoonraad Stephanie J Bryant Robert R McLeod Virginia L Ferguson Source Type: research
In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula
Ann Biomed Eng. 2024 Apr 28. doi: 10.1007/s10439-024-03504-1. Online ahead of print.ABSTRACTThe unacceptably high stroke rate associated with HeartMate 3 ventricular assist device (VAD) without signs of adherent pump thrombosis is hypothesized to be the result of the emboli produced by the inflow cannula, that are ingested and ejected from the pump. This in vitro and numerical study aimed to emulate the surface features and supraphysiological shear of a ventricular cannula to provide insight into their effect on thrombogenesis. Human whole blood was perfused at calibrated flow rates in a microfluidic channel to achieve she...
Source: Annals of Biomedical Engineering - April 28, 2024 Category: Biomedical Engineering Authors: Wenxuan He Abhishek Karmakar Junhyuk Kang Grant Rowlands Samuel Schirmacher Rodrigo M éndez-Rojano James Antaki Source Type: research
In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula
Ann Biomed Eng. 2024 Apr 28. doi: 10.1007/s10439-024-03504-1. Online ahead of print.ABSTRACTThe unacceptably high stroke rate associated with HeartMate 3 ventricular assist device (VAD) without signs of adherent pump thrombosis is hypothesized to be the result of the emboli produced by the inflow cannula, that are ingested and ejected from the pump. This in vitro and numerical study aimed to emulate the surface features and supraphysiological shear of a ventricular cannula to provide insight into their effect on thrombogenesis. Human whole blood was perfused at calibrated flow rates in a microfluidic channel to achieve she...
Source: Annals of Biomedical Engineering - April 28, 2024 Category: Biomedical Engineering Authors: Wenxuan He Abhishek Karmakar Junhyuk Kang Grant Rowlands Samuel Schirmacher Rodrigo M éndez-Rojano James Antaki Source Type: research
Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application
This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioact...
Source: Annals of Biomedical Engineering - April 25, 2024 Category: Biomedical Engineering Authors: Marijana R Pantovi ć Pavlović Nenad L Ignjatovi ć Senka Gudi ć Ladislav Vrsalovi ć Katarina Đ Božić Marko E Popovi ć Miroslav M Pavlovi ć Source Type: research
Contribution of Red Blood Cells and Platelets to Blood Clot Computed Tomography Imaging and Compressive Mechanical Characteristics
The objective of the current study was to examine the individual and combined effects of blood clot RBC and platelet content on resultant CT imaging and mechanical characteristics. Human blood clot analogues were prepared from a combination of preselected RBC volumes and platelet concentrations to decouple their contributions. The resulting clot RBC content (%) and platelet content (%) were determined using Martius Scarlet Blue and CD42b staining, respectively. Non-contrast and contrast-enhanced CT (NCCT and CECT) scans were performed to measure the clot densities. CECT density increase was taken as a proxy for clinical pe...
Source: Annals of Biomedical Engineering - April 25, 2024 Category: Biomedical Engineering Authors: Rachel M E Cahalane Janneke M H Cruts Heleen M M van Beusekom Moniek P M de Maat Marcel Dijkshoorn Aad van der Lugt Frank J H Gijsen Source Type: research
Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application
This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioact...
Source: Annals of Biomedical Engineering - April 25, 2024 Category: Biomedical Engineering Authors: Marijana R Pantovi ć Pavlović Nenad L Ignjatovi ć Senka Gudi ć Ladislav Vrsalovi ć Katarina Đ Božić Marko E Popovi ć Miroslav M Pavlovi ć Source Type: research
Contribution of Red Blood Cells and Platelets to Blood Clot Computed Tomography Imaging and Compressive Mechanical Characteristics
The objective of the current study was to examine the individual and combined effects of blood clot RBC and platelet content on resultant CT imaging and mechanical characteristics. Human blood clot analogues were prepared from a combination of preselected RBC volumes and platelet concentrations to decouple their contributions. The resulting clot RBC content (%) and platelet content (%) were determined using Martius Scarlet Blue and CD42b staining, respectively. Non-contrast and contrast-enhanced CT (NCCT and CECT) scans were performed to measure the clot densities. CECT density increase was taken as a proxy for clinical pe...
Source: Annals of Biomedical Engineering - April 25, 2024 Category: Biomedical Engineering Authors: Rachel M E Cahalane Janneke M H Cruts Heleen M M van Beusekom Moniek P M de Maat Marcel Dijkshoorn Aad van der Lugt Frank J H Gijsen Source Type: research
Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application
This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioact...
Source: Annals of Biomedical Engineering - April 25, 2024 Category: Biomedical Engineering Authors: Marijana R Pantovi ć Pavlović Nenad L Ignjatovi ć Senka Gudi ć Ladislav Vrsalovi ć Katarina Đ Božić Marko E Popovi ć Miroslav M Pavlovi ć Source Type: research
