Annals Video Summary - Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials
Ann Intern Med. 2024 Apr 30:eM240739. doi: 10.7326/M24-0739. Online ahead of print.NO ABSTRACTPMID:38684098 | DOI:10.7326/M24-0739 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Source Type: research
Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
CONCLUSION: This emulated target trial showed that SGLT2i use was associated with a lower risk for dialysis, cardiovascular events, DKA, and AKI than no SGLT2i use in patients with T2D and stage 5 CKD.PRIMARY FUNDING SOURCE: National Health Research Institutes, Taiwan.PMID:38684099 | DOI:10.7326/M23-1874 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Fu-Shun Yen Chii-Min Hwu Jia-Sin Liu Yi-Ling Wu Keong Chong Chih-Cheng Hsu Source Type: research
The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research
Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research
The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research
Medicare Negotiation's Drug Reformulation Problem
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M24-0138. Online ahead of print.NO ABSTRACTPMID:38684103 | DOI:10.7326/M24-0138 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Matthew Vogel Benjamin N Rome Aaron S Kesselheim William B Feldman Source Type: research
Annals Video Summary - Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials
Ann Intern Med. 2024 Apr 30:eM240739. doi: 10.7326/M24-0739. Online ahead of print.NO ABSTRACTPMID:38684098 | DOI:10.7326/M24-0739 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Source Type: research
Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
CONCLUSION: This emulated target trial showed that SGLT2i use was associated with a lower risk for dialysis, cardiovascular events, DKA, and AKI than no SGLT2i use in patients with T2D and stage 5 CKD.PRIMARY FUNDING SOURCE: National Health Research Institutes, Taiwan.PMID:38684099 | DOI:10.7326/M23-1874 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Fu-Shun Yen Chii-Min Hwu Jia-Sin Liu Yi-Ling Wu Keong Chong Chih-Cheng Hsu Source Type: research
The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research
Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research
The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research
Medicare Negotiation's Drug Reformulation Problem
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M24-0138. Online ahead of print.NO ABSTRACTPMID:38684103 | DOI:10.7326/M24-0138 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Matthew Vogel Benjamin N Rome Aaron S Kesselheim William B Feldman Source Type: research
Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex
CONCLUSION: The findings indicate that patients have lower mortality and readmission rates when treated by female physicians, and the benefit of receiving treatments from female physicians is larger for female patients than for male patients.PRIMARY FUNDING SOURCE: Gregory Annenberg Weingarten, GRoW @ Annenberg.PMID:38648639 | DOI:10.7326/M23-3163 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Atsushi Miyawaki Anupam B Jena Lisa S Rotenstein Yusuke Tsugawa Source Type: research
Effect of Health Service Area on Primary Care Physician Provision of Low-Value Cancer Screening
CONCLUSION: Physicians relocating to service areas with lower rates of LVC provided less LVC than physicians who stayed in areas with higher rates of LVC. Systemic structures may contribute to LVC. Understanding which factors are contributing may present opportunities for policy and interventions to broadly improve care.PRIMARY FUNDING SOURCE: National Cancer Institute of the National Institutes of Health.PMID:38648640 | DOI:10.7326/M23-1456 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Kassandra Dindinger-Hill Joshua Horns Jacob Ambrose Jeffrey Vehawn Mouneeb Choudry Trevor C Hunt Jonathan Chipman Benjamin Haaland Jiaming Li Heidi A Hanson Brock O'Neil Source Type: research
"Redlining" Maps and Contemporary Firearm Violence Research: Is It Time to Ask New Questions?
Ann Intern Med. 2024 Apr 23. doi: 10.7326/M24-0870. Online ahead of print.NO ABSTRACTPMID:38648641 | DOI:10.7326/M24-0870 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Sara F Jacoby Eugenia C South Source Type: research
