Reading and Writing the Human Glycocode
Annu Rev Biochem. 2024 Apr 26. doi: 10.1146/annurev-biochem-030122-044347. Online ahead of print.NO ABSTRACTPMID:38669516 | DOI:10.1146/annurev-biochem-030122-044347 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - April 26, 2024 Category: Biochemistry Authors: Noortje de Haan Mathias I Nielsen Hans H Wandall Source Type: research
Reading and Writing the Human Glycocode
Annu Rev Biochem. 2024 Apr 26. doi: 10.1146/annurev-biochem-030122-044347. Online ahead of print.ABSTRACTThe complex carbohydrate structures decorating human proteins and lipids, also called glycans, are abundantly present at cell surfaces and in the secretome. Glycosylation is vital for biological processes including cell-cell recognition, immune responses, and signaling pathways. Therefore, the structural and functional characterization of the human glycome is gaining more and more interest in basic biochemistry research and in the context of developing new therapies, diagnostic tools, and biotechnology applications. For...
Source: Annual Review of Biochemistry - April 26, 2024 Category: Biochemistry Authors: Noortje de Haan Mathias I Nielsen Hans H Wandall Source Type: research
Reading and Writing the Human Glycocode
Annu Rev Biochem. 2024 Apr 26. doi: 10.1146/annurev-biochem-030122-044347. Online ahead of print.ABSTRACTThe complex carbohydrate structures decorating human proteins and lipids, also called glycans, are abundantly present at cell surfaces and in the secretome. Glycosylation is vital for biological processes including cell-cell recognition, immune responses, and signaling pathways. Therefore, the structural and functional characterization of the human glycome is gaining more and more interest in basic biochemistry research and in the context of developing new therapies, diagnostic tools, and biotechnology applications. For...
Source: Annual Review of Biochemistry - April 26, 2024 Category: Biochemistry Authors: Noortje de Haan Mathias I Nielsen Hans H Wandall Source Type: research
Reading and Writing the Human Glycocode
Annu Rev Biochem. 2024 Apr 26. doi: 10.1146/annurev-biochem-030122-044347. Online ahead of print.ABSTRACTThe complex carbohydrate structures decorating human proteins and lipids, also called glycans, are abundantly present at cell surfaces and in the secretome. Glycosylation is vital for biological processes including cell-cell recognition, immune responses, and signaling pathways. Therefore, the structural and functional characterization of the human glycome is gaining more and more interest in basic biochemistry research and in the context of developing new therapies, diagnostic tools, and biotechnology applications. For...
Source: Annual Review of Biochemistry - April 26, 2024 Category: Biochemistry Authors: Noortje de Haan Mathias I Nielsen Hans H Wandall Source Type: research
Structure and Mechanisms of Assembly-Line Polyketide Synthases
Annu Rev Biochem. 2024 Apr 25. doi: 10.1146/annurev-biochem-080923-043654. Online ahead of print.ABSTRACTThree decades of studies on the multifunctional 6-deoxyerythronolide B synthase have laid a foundation for understanding the chemistry and evolution of polyketide antibiotic biosynthesis by a large family of versatile enzymatic assembly lines. Recent progress in applying chemical and structural biology tools to this prototypical assembly-line polyketide synthase (PKS) and related systems has highlighted several features of their catalytic cycles and associated protein dynamics. There is compelling evidence that multiple...
Source: Annual Review of Biochemistry - April 25, 2024 Category: Biochemistry Authors: Alexander M Soohoo Dillon P Cogan Krystal L Brodsky Chaitan Khosla Source Type: research
Structure and Mechanisms of Assembly-Line Polyketide Synthases
Annu Rev Biochem. 2024 Apr 25. doi: 10.1146/annurev-biochem-080923-043654. Online ahead of print.ABSTRACTThree decades of studies on the multifunctional 6-deoxyerythronolide B synthase have laid a foundation for understanding the chemistry and evolution of polyketide antibiotic biosynthesis by a large family of versatile enzymatic assembly lines. Recent progress in applying chemical and structural biology tools to this prototypical assembly-line polyketide synthase (PKS) and related systems has highlighted several features of their catalytic cycles and associated protein dynamics. There is compelling evidence that multiple...
Source: Annual Review of Biochemistry - April 25, 2024 Category: Biochemistry Authors: Alexander M Soohoo Dillon P Cogan Krystal L Brodsky Chaitan Khosla Source Type: research
Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era
Annu Rev Biochem. 2024 Apr 19. doi: 10.1146/annurev-biochem-032620-104731. Online ahead of print.ABSTRACTNatural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification, biosynthetic origins, and the microbiological and genetic methods used for their discovery. We also describe and discuss the technologies that revolutionized the field, which transitioned from classic genetics to genome-centric discovery approximately two decades ago. We then highlight the most recent advancements and approaches in the...
Source: Annual Review of Biochemistry - April 19, 2024 Category: Biochemistry Authors: Carolina Cano-Prieto Agustina Undabarrena Ana Calheiros de Carvalho Jay D Keasling Pablo Cruz-Morales Source Type: research
Soluble Human Lectins at the Host-Microbe Interface
Annu Rev Biochem. 2024 Apr 19. doi: 10.1146/annurev-biochem-062917-012322. Online ahead of print.ABSTRACTHuman lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their roles, their production can vary with tissue type. They also can have unique structural and biochemical properties, and they can influence microbial colonization at sites proximal and distal to their tissue of origin. In line with their classification as innate immune proteins, soluble le...
Source: Annual Review of Biochemistry - April 19, 2024 Category: Biochemistry Authors: Amanda L Peiffer A E Dugan L L Kiessling Source Type: research
Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era
Annu Rev Biochem. 2024 Apr 19. doi: 10.1146/annurev-biochem-032620-104731. Online ahead of print.ABSTRACTNatural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification, biosynthetic origins, and the microbiological and genetic methods used for their discovery. We also describe and discuss the technologies that revolutionized the field, which transitioned from classic genetics to genome-centric discovery approximately two decades ago. We then highlight the most recent advancements and approaches in the...
Source: Annual Review of Biochemistry - April 19, 2024 Category: Biochemistry Authors: Carolina Cano-Prieto Agustina Undabarrena Ana Calheiros de Carvalho Jay D Keasling Pablo Cruz-Morales Source Type: research
Soluble Human Lectins at the Host-Microbe Interface
Annu Rev Biochem. 2024 Apr 19. doi: 10.1146/annurev-biochem-062917-012322. Online ahead of print.ABSTRACTHuman lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their roles, their production can vary with tissue type. They also can have unique structural and biochemical properties, and they can influence microbial colonization at sites proximal and distal to their tissue of origin. In line with their classification as innate immune proteins, soluble le...
Source: Annual Review of Biochemistry - April 19, 2024 Category: Biochemistry Authors: Amanda L Peiffer A E Dugan L L Kiessling Source Type: research
ATP-Dependent Steps in Peroxisomal Protein Import
Annu Rev Biochem. 2024 Apr 15. doi: 10.1146/annurev-biochem-030222-111227. Online ahead of print.ABSTRACTPeroxisomes are organelles that play a central role in lipid metabolism and cellular redox homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal (PTS) receptors is an ATP-dependent mechanism. However, the energy-dependent steps do not occur early during the binding of the receptor-cargo complex to the membrane but late, because they are linked to the peroxisomal export complex for the release of the unloaded receptor. The first ATP-demanding step is the cysteine-dependent monoubiquitinat...
Source: Annual Review of Biochemistry - April 15, 2024 Category: Biochemistry Authors: Harald W Platta Julia Jeske Nadine Schmidt Ralf Erdmann Source Type: research
Leucine-Rich Repeat Kinases
We present here our current understanding of the structure, biochemical properties, and cell biology of LRRK2 and its related paralog LRRK1 and discuss how this information guides the generation of LRRK2 inhibitors for the potential benefit of patients.PMID:38621236 | DOI:10.1146/annurev-biochem-030122-051144 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - April 15, 2024 Category: Biochemistry Authors: Dario R Alessi Suzanne R Pfeffer Source Type: research
ATP-Dependent Steps in Peroxisomal Protein Import
Annu Rev Biochem. 2024 Apr 15. doi: 10.1146/annurev-biochem-030222-111227. Online ahead of print.ABSTRACTPeroxisomes are organelles that play a central role in lipid metabolism and cellular redox homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal (PTS) receptors is an ATP-dependent mechanism. However, the energy-dependent steps do not occur early during the binding of the receptor-cargo complex to the membrane but late, because they are linked to the peroxisomal export complex for the release of the unloaded receptor. The first ATP-demanding step is the cysteine-dependent monoubiquitinat...
Source: Annual Review of Biochemistry - April 15, 2024 Category: Biochemistry Authors: Harald W Platta Julia Jeske Nadine Schmidt Ralf Erdmann Source Type: research
Leucine-Rich Repeat Kinases
We present here our current understanding of the structure, biochemical properties, and cell biology of LRRK2 and its related paralog LRRK1 and discuss how this information guides the generation of LRRK2 inhibitors for the potential benefit of patients.PMID:38621236 | DOI:10.1146/annurev-biochem-030122-051144 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - April 15, 2024 Category: Biochemistry Authors: Dario R Alessi Suzanne R Pfeffer Source Type: research
ATP-Dependent Steps in Peroxisomal Protein Import
Annu Rev Biochem. 2024 Apr 15. doi: 10.1146/annurev-biochem-030222-111227. Online ahead of print.ABSTRACTPeroxisomes are organelles that play a central role in lipid metabolism and cellular redox homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal (PTS) receptors is an ATP-dependent mechanism. However, the energy-dependent steps do not occur early during the binding of the receptor-cargo complex to the membrane but late, because they are linked to the peroxisomal export complex for the release of the unloaded receptor. The first ATP-demanding step is the cysteine-dependent monoubiquitinat...
Source: Annual Review of Biochemistry - April 15, 2024 Category: Biochemistry Authors: Harald W Platta Julia Jeske Nadine Schmidt Ralf Erdmann Source Type: research
