Corrigendum to "Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism" Antiviral Res. 2023 Aug:216:105662]
Antiviral Res. 2024 Mar 19:105860. doi: 10.1016/j.antiviral.2024.105860. Online ahead of print.NO ABSTRACTPMID:38508907 | DOI:10.1016/j.antiviral.2024.105860 (Source: Antiviral Research)
Source: Antiviral Research - March 20, 2024 Category: Virology Authors: Siyuan Ma Mengjiao Lv Xiaohua Chen Guoqing Zang Zhenghao Tang Yi Zhang Weiwei Hu Source Type: research
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication
Antiviral Res. 2024 Mar 14:105859. doi: 10.1016/j.antiviral.2024.105859. Online ahead of print.ABSTRACTAntiviral therapeutics are highly effective countermeasures for the treatment of coronavirus disease 2019 (COVID-19). However, development of resistance to antivirals undermines their effectiveness. Combining multiple antivirals during patient treatment has the potential to overcome the evolutionary selective pressure towards antiviral resistance, as well as provide a more robust and efficacious treatment option. The current evidence for effective antiviral combinations to inhibit severe acute respiratory syndrome coronav...
Source: Antiviral Research - March 16, 2024 Category: Virology Authors: Christopher Moon Eleanor Porges Adam Roberts Joanna Bacon Source Type: research
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication
Antiviral Res. 2024 Mar 14:105859. doi: 10.1016/j.antiviral.2024.105859. Online ahead of print.ABSTRACTAntiviral therapeutics are highly effective countermeasures for the treatment of coronavirus disease 2019 (COVID-19). However, development of resistance to antivirals undermines their effectiveness. Combining multiple antivirals during patient treatment has the potential to overcome the evolutionary selective pressure towards antiviral resistance, as well as provide a more robust and efficacious treatment option. The current evidence for effective antiviral combinations to inhibit severe acute respiratory syndrome coronav...
Source: Antiviral Research - March 16, 2024 Category: Virology Authors: Christopher Moon Eleanor Porges Adam Roberts Joanna Bacon Source Type: research
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication
Antiviral Res. 2024 Mar 14:105859. doi: 10.1016/j.antiviral.2024.105859. Online ahead of print.ABSTRACTAntiviral therapeutics are highly effective countermeasures for the treatment of coronavirus disease 2019 (COVID-19). However, development of resistance to antivirals undermines their effectiveness. Combining multiple antivirals during patient treatment has the potential to overcome the evolutionary selective pressure towards antiviral resistance, as well as provide a more robust and efficacious treatment option. The current evidence for effective antiviral combinations to inhibit severe acute respiratory syndrome coronav...
Source: Antiviral Research - March 16, 2024 Category: Virology Authors: Christopher Moon Eleanor Porges Adam Roberts Joanna Bacon Source Type: research
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication
Antiviral Res. 2024 Mar 14:105859. doi: 10.1016/j.antiviral.2024.105859. Online ahead of print.ABSTRACTAntiviral therapeutics are highly effective countermeasures for the treatment of coronavirus disease 2019 (COVID-19). However, development of resistance to antivirals undermines their effectiveness. Combining multiple antivirals during patient treatment has the potential to overcome the evolutionary selective pressure towards antiviral resistance, as well as provide a more robust and efficacious treatment option. The current evidence for effective antiviral combinations to inhibit severe acute respiratory syndrome coronav...
Source: Antiviral Research - March 16, 2024 Category: Virology Authors: Christopher Moon Eleanor Porges Adam Roberts Joanna Bacon Source Type: research
β-D-N < sup > 4 < /sup > -hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding
Antiviral Res. 2024 Mar 13:105858. doi: 10.1016/j.antiviral.2024.105858. Online ahead of print.ABSTRACTChikungunya virus (CHIKV) is a mosquito-borne virus transmitted by Aedes mosquitoes. While there are no antiviral therapies currently available to treat CHIKV infections, several licensed oral drugs have shown significant anti-CHIKV activity in cells and in mouse models. However, the efficacy in mosquitoes has not yet been assessed. Such cross-species antiviral activity could be favorable, since virus inhibition in the mosquito vector might prevent further transmission to vertebrate hosts. Here, we explored the antiviral ...
Source: Antiviral Research - March 15, 2024 Category: Virology Authors: Ana Lucia Rosales-Rosas Alina Soto Lanjiao Wang Raf Mols Albin Fontaine Aboubakar Sanon Patrick Augustijns Leen Delang Source Type: research
Caffeic acid phenethyl ester: An effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus
Antiviral Res. 2024 Mar 13:105868. doi: 10.1016/j.antiviral.2024.105868. Online ahead of print.ABSTRACTPorcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both ...
Source: Antiviral Research - March 15, 2024 Category: Virology Authors: Zhanding Cui Jing Zhang Jinlong Wang Jinlong Liu Pu Sun Jiaoyang Li Guoxiu Li Ying Sun Juanbin Ying Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Yimei Cao Zengjun Lu Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 8;225:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded and positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 ...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 8;225:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded and positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 ...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 8;225:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded and positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 ...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 7:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded, positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 is a se...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 7:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded, positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 is a se...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Construction of exosome-loaded LL-37 and its protection against zika virus infection
Antiviral Res. 2024 Mar 7:105855. doi: 10.1016/j.antiviral.2024.105855. Online ahead of print.ABSTRACTZika virus (ZIKV) is an enveloped, single-stranded, positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 is a se...
Source: Antiviral Research - March 9, 2024 Category: Virology Authors: Chen Wang Min Li Xiaohui Xia Yuxuan Fu Yi Wang Wei Xu Hongqi Wei Lin Wei Source Type: research
Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines
Antiviral Res. 2024 Mar 6:105851. doi: 10.1016/j.antiviral.2024.105851. Online ahead of print.ABSTRACTCurrently, there are two approved vaccine regimens designed to prevent Ebola virus (EBOV) disease (EVD). Both are virus-vectored, and concerns about cold-chain storage and pre-existing immunity to the vectors warrant investigating additional vaccine strategies. Here, we have explored the utility of adjuvanted recombinant glycoproteins (GPs) from ebolaviruses Zaire (EBOV), Sudan (SUDV), and Bundibugyo (BDBV) for inducing antibody (Ab) and T cell cross-reactivity. Glycoproteins expressed in insect cells were administered to ...
Source: Antiviral Research - March 8, 2024 Category: Virology Authors: Jiin Felgner Elizabeth Clarke Jenny E Hernandez-Davies Sharon Jan Ariel Wirchnianski Aarti Jain Rie Nakajima Algimantas Jasinskas Erwin Strahsberger Kartik Chandran Steven Bradfute D Huw Davies Source Type: research
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential
In this study, we focused on the capacity of SARS-CoV-2 Alpha and Delta variants to activate the NLRP3 inflammasome. We compared the macrophage activation, particularly the inflammasome formation, using Alpha- and Delta-spike virus-like particles (VLPs). We found that VLPs of both variants activated the inflammasome even without a priming step. Delta-spike VLPs had a significantly stronger effect on triggering pyroptosis and inflammasome assembly in THP-1 macrophages than did Alfa-spike VLPs. Cells treated with Delta VLPs showed greater cleavage of caspase-1 and IL-1β release. Furthermore, Delta VLPs induced stronger cyto...
Source: Antiviral Research - March 7, 2024 Category: Virology Authors: Magdalena Bandyszewska Magdalena Ambro żek-Latecka Gra żyna Hoser Ma łgorzata Grzanka Franziska Hornung Stefanie Deinhardt-Emmer Tomasz Skirecki Source Type: research
