Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Arch Toxicol. 2024 May 2. doi: 10.1007/s00204-024-03759-6. Online ahead of print.ABSTRACTGrouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source substance(s). While the chemical industry and the regulators recognise its benefits, registration dossiers are often rejected due to weak analogue/category justifications based largely on the structural similarity of source and target substances. Here we demonstrate how multi-omics measurements can improve confidence in grouping via a statistical assessment of the similarity of molecular effects. Six azo dyes provided...
Source: Archives of Toxicology - May 2, 2024 Category: Toxicology Authors: Hanna Gruszczynska Rosemary E Barnett Gavin R Lloyd Ralf J M Weber Thomas N Lawson Jiarui Zhou Elena Sostare John K Colbourne Mark R Viant Source Type: research
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Arch Toxicol. 2024 May 2. doi: 10.1007/s00204-024-03759-6. Online ahead of print.ABSTRACTGrouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source substance(s). While the chemical industry and the regulators recognise its benefits, registration dossiers are often rejected due to weak analogue/category justifications based largely on the structural similarity of source and target substances. Here we demonstrate how multi-omics measurements can improve confidence in grouping via a statistical assessment of the similarity of molecular effects. Six azo dyes provided...
Source: Archives of Toxicology - May 2, 2024 Category: Toxicology Authors: Hanna Gruszczynska Rosemary E Barnett Gavin R Lloyd Ralf J M Weber Thomas N Lawson Jiarui Zhou Elena Sostare John K Colbourne Mark R Viant Source Type: research
Avoiding a reproducibility crisis in regulatory toxicology-on the fundamental role of ring trials
Arch Toxicol. 2024 Apr 30. doi: 10.1007/s00204-024-03736-z. Online ahead of print.ABSTRACTThe ongoing transition from chemical hazard and risk assessment based on animal studies to assessment relying mostly on non-animal data, requires a multitude of novel experimental methods, and this means that guidance on the validation and standardisation of test methods intended for international applicability and acceptance, needs to be updated. These so-called new approach methodologies (NAMs) must be applicable to the chemical regulatory domain and provide reliable data which are relevant to hazard and risk assessment. Confidence ...
Source: Archives of Toxicology - April 30, 2024 Category: Toxicology Authors: Miriam N Jacobs Sebastian Hoffmann Heli M Hollnagel Petra Kern Susanne N Kolle Andreas Natsch Robert Landsiedel Source Type: research
Avoiding a reproducibility crisis in regulatory toxicology-on the fundamental role of ring trials
Arch Toxicol. 2024 Apr 30. doi: 10.1007/s00204-024-03736-z. Online ahead of print.ABSTRACTThe ongoing transition from chemical hazard and risk assessment based on animal studies to assessment relying mostly on non-animal data, requires a multitude of novel experimental methods, and this means that guidance on the validation and standardisation of test methods intended for international applicability and acceptance, needs to be updated. These so-called new approach methodologies (NAMs) must be applicable to the chemical regulatory domain and provide reliable data which are relevant to hazard and risk assessment. Confidence ...
Source: Archives of Toxicology - April 30, 2024 Category: Toxicology Authors: Miriam N Jacobs Sebastian Hoffmann Heli M Hollnagel Petra Kern Susanne N Kolle Andreas Natsch Robert Landsiedel Source Type: research
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs
Arch Toxicol. 2024 Apr 30. doi: 10.1007/s00204-024-03760-z. Online ahead of print.ABSTRACTAntibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic reactions, teratogenicity, carcinogenicity, changes in the microbiota and, in particular, antibiotic resistance. Therefore, it may b...
Source: Archives of Toxicology - April 29, 2024 Category: Toxicology Authors: Merve G üdül Bacanlı Source Type: research
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs
Arch Toxicol. 2024 Apr 30. doi: 10.1007/s00204-024-03760-z. Online ahead of print.ABSTRACTAntibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic reactions, teratogenicity, carcinogenicity, changes in the microbiota and, in particular, antibiotic resistance. Therefore, it may b...
Source: Archives of Toxicology - April 29, 2024 Category: Toxicology Authors: Merve G üdül Bacanlı Source Type: research
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study
Arch Toxicol. 2024 Apr 26. doi: 10.1007/s00204-024-03717-2. Online ahead of print.ABSTRACT2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers. Blood and urine samp...
Source: Archives of Toxicology - April 26, 2024 Category: Toxicology Authors: Elisabeth Eckert Thomas J äger Julia Hiller Edgar Leibold Michael Bader Thomas G öen Source Type: research
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study
Arch Toxicol. 2024 Apr 26. doi: 10.1007/s00204-024-03717-2. Online ahead of print.ABSTRACT2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers. Blood and urine samp...
Source: Archives of Toxicology - April 26, 2024 Category: Toxicology Authors: Elisabeth Eckert Thomas J äger Julia Hiller Edgar Leibold Michael Bader Thomas G öen Source Type: research
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study
Arch Toxicol. 2024 Apr 26. doi: 10.1007/s00204-024-03717-2. Online ahead of print.ABSTRACT2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers. Blood and urine samp...
Source: Archives of Toxicology - April 26, 2024 Category: Toxicology Authors: Elisabeth Eckert Thomas J äger Julia Hiller Edgar Leibold Michael Bader Thomas G öen Source Type: research
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
In this study, we derived TCMGs from metabolic pathways of polycyclic aromatic hydrocarbons and tobacco-specific nitrosamines, and then explored genetic associations between TCMGs and bladder cancer risk in two populations: a Chinese population of 580 cases and 1101 controls, and a European population of 5930 cases and 5468 controls, along with interaction and joint analyses. Expression patterns of TCMGs were sourced from Nanjing Bladder Cancer (NJBC) study and publicly available datasets. Among 43 TCMGs, we observed that rs7087341 T > A in AKR1C2 was associated with a reduced risk of bladder cancer in the Chinese popul...
Source: Archives of Toxicology - April 25, 2024 Category: Toxicology Authors: Yanping Xiao Yang Shen Hui Song Fang Gao Zhenguang Mao Qiang Lv Chao Qin Lin Yuan Dongmei Wu Haiyan Chu Meilin Wang Mulong Du Rui Zheng Zhengdong Zhang Source Type: research
The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin
Arch Toxicol. 2024 Apr 25. doi: 10.1007/s00204-024-03743-0. Online ahead of print.ABSTRACTAlternaria species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C14H10O5) is an isocoumarins produced by different species of Alternaria including Alternaria alternata. AOH is often found in grain, fruits and fruits-based food products with high levels in legumes, nuts, and tomatoes. AOH was first discovered in 1953, and it is nowadays linked to esophagus cancer an...
Source: Archives of Toxicology - April 25, 2024 Category: Toxicology Authors: Iman Saleh Randa Zeidan Mohammed Abu-Dieyeh Source Type: research
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
In this study, we derived TCMGs from metabolic pathways of polycyclic aromatic hydrocarbons and tobacco-specific nitrosamines, and then explored genetic associations between TCMGs and bladder cancer risk in two populations: a Chinese population of 580 cases and 1101 controls, and a European population of 5930 cases and 5468 controls, along with interaction and joint analyses. Expression patterns of TCMGs were sourced from Nanjing Bladder Cancer (NJBC) study and publicly available datasets. Among 43 TCMGs, we observed that rs7087341 T > A in AKR1C2 was associated with a reduced risk of bladder cancer in the Chinese popul...
Source: Archives of Toxicology - April 25, 2024 Category: Toxicology Authors: Yanping Xiao Yang Shen Hui Song Fang Gao Zhenguang Mao Qiang Lv Chao Qin Lin Yuan Dongmei Wu Haiyan Chu Meilin Wang Mulong Du Rui Zheng Zhengdong Zhang Source Type: research
The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin
Arch Toxicol. 2024 Apr 25. doi: 10.1007/s00204-024-03743-0. Online ahead of print.ABSTRACTAlternaria species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C14H10O5) is an isocoumarins produced by different species of Alternaria including Alternaria alternata. AOH is often found in grain, fruits and fruits-based food products with high levels in legumes, nuts, and tomatoes. AOH was first discovered in 1953, and it is nowadays linked to esophagus cancer an...
Source: Archives of Toxicology - April 25, 2024 Category: Toxicology Authors: Iman Saleh Randa Zeidan Mohammed Abu-Dieyeh Source Type: research
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters
In conclusion, these results indicate that not all substances contribute equally (or at all) to the systemic exposure to salicylic acid. Therefore, we propose a realistic metabolism correction factor by which the potential contribution of salicylate esters to the aggregate consumer exposure to salicylic acid from cosmetic use can be estimated.PMID:38658404 | DOI:10.1007/s00204-024-03749-8 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 24, 2024 Category: Toxicology Authors: Abdulkarim Najjar Sebastien Gr égoire Beate Nicol Andreas Natsch Nazanin Golbamaki Fanny Boisleve Amaia Irizar Brian Wall Angus Swinscoe Val érie Masini-Etévé Dan Selechnik Anne Marie Api Peter Griem Nicola Hewitt Estefania Cardamone Source Type: research
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NF κB pro-inflammatory pathway and intracellular ROS generation
In conclusion, 3-BrFlu is a hazardous substance that results in vascular endothelial dysfunction through the MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation.PMID:38635053 | DOI:10.1007/s00204-024-03751-0 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 18, 2024 Category: Toxicology Authors: Chien-Ying Lee Sheng-Wen Wu Jiann-Jou Yang Wen-Ying Chen Chun-Jung Chen Hsin-Hung Chen Yi-Chia Lee Chun-Hung Su Yu-Hsiang Kuan Source Type: research
