Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was ...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Ramadan S Hussein Moustafa M Eyada Rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Source Type: research
Orchiopexy: one procedure, two diagnoses - different male infertility outcomes
Asian J Androl. 2024 Apr 19. doi: 10.4103/aja202410. Online ahead of print.ABSTRACTInfertility, affecting one in six couples, is often related to the male partner's congenital and/or environmental conditions or complications postsurgery. This retrospective study examines the link between orchiopexy for undescended testicles (UDT) and testicular torsion (TT) in childhood and adult fertility as assessed through sperm analysis. The study involved the analysis of semen samples from 7743 patients collected at Soroka University Medical Center (Beer Sheva, Israel) between January 2009 and December 2017. Patients were classified i...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Nitza Heiman Newman Idan Farber Eitan Lunenfeld Atif Zeadna Iris Har Vardi Zaki Assi Source Type: research
Male reproductive function before and after the adjustment of the COVID-19 prevention policy: a multicenter study in China
Asian J Androl. 2024 Apr 19. doi: 10.4103/aja202388. Online ahead of print.ABSTRACTAt the end of 2022, the adjustment of the coronavirus disease 2019 (COVID-19) pandemic control policy in China resulted in a large-scale increase in public infection. To compare the fertility parameters of male patients before and after the adjustments of the COVID-19 pandemic control policy in China, we collected data on patients' medical histories and laboratory examinations on their first visits between June 2022 and March 2023 in five different hospitals. Data were divided into five groups according to the timeline of the policy adjustme...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Jian-Zheng Li Han Wu Li Wang Yun-Shan Wang Feng Kong Long-Qiao Cao Ming Liang Xiong Wang Ming-Zhen Yuan Source Type: research
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was ...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Ramadan S Hussein Moustafa M Eyada Rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Source Type: research
Orchiopexy: one procedure, two diagnoses - different male infertility outcomes
Asian J Androl. 2024 Apr 19. doi: 10.4103/aja202410. Online ahead of print.ABSTRACTInfertility, affecting one in six couples, is often related to the male partner's congenital and/or environmental conditions or complications postsurgery. This retrospective study examines the link between orchiopexy for undescended testicles (UDT) and testicular torsion (TT) in childhood and adult fertility as assessed through sperm analysis. The study involved the analysis of semen samples from 7743 patients collected at Soroka University Medical Center (Beer Sheva, Israel) between January 2009 and December 2017. Patients were classified i...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Nitza Heiman Newman Idan Farber Eitan Lunenfeld Atif Zeadna Iris Har Vardi Zaki Assi Source Type: research
Male reproductive function before and after the adjustment of the COVID-19 prevention policy: a multicenter study in China
Asian J Androl. 2024 Apr 19. doi: 10.4103/aja202388. Online ahead of print.ABSTRACTAt the end of 2022, the adjustment of the coronavirus disease 2019 (COVID-19) pandemic control policy in China resulted in a large-scale increase in public infection. To compare the fertility parameters of male patients before and after the adjustments of the COVID-19 pandemic control policy in China, we collected data on patients' medical histories and laboratory examinations on their first visits between June 2022 and March 2023 in five different hospitals. Data were divided into five groups according to the timeline of the policy adjustme...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Jian-Zheng Li Han Wu Li Wang Yun-Shan Wang Feng Kong Long-Qiao Cao Ming Liang Xiong Wang Ming-Zhen Yuan Source Type: research
Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer
This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). PubMed, EMBASE, and the Cochrane Library were comprehensively searched for eligible randomized controlled trials (RCTs) published from inception to October 2023. Interventions included abiraterone, apalutamide, enzalutamide, docetaxel, darolutamide, and androgen deprivation therapy (ADT), either as doublet or triplet therapies. The outcomes examined were overall survival (OS), progression-free survival (PFS), castration-resistant prostate cancer (CRPC)-free survival, time to symptomat...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Shan-Shan Wang Xiao-Jie Bian Jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei Ye Source Type: research
Transrectal versus transperineal prostate biopsy for cancer detection in patients with gray-zone prostate-specific antigen: a multicenter, real-world study
Asian J Androl. 2024 Apr 16. doi: 10.4103/aja20241. Online ahead of print.ABSTRACTKnowledge about the effect of different prostate biopsy approaches on the prostate cancer detection rate (CDR) in patients with gray-zone prostate-specific antigen (PSA) is limited. We performed this study to compare the CDR among patients who underwent different biopsy approaches and had rising PSA levels in the gray zone. Two hundred and twenty-two patients who underwent transrectal prostate biopsy (TRB) and 216 patients who underwent transperineal prostate biopsy (TPB) between June 2016 and September 2022 were reviewed in this study. In ad...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Jun-Xiao Liu Ze-Yuan Wang Shao-Xi Niu Xiao-Yong Sai Xu Zhang Xue-Pei Zhang Xin Ma Source Type: research
Machine learning approach to assess the association between anthropometric, metabolic, and nutritional status and semen parameters
This study, consistent with previous publications, suggests that beyond semen quality parameters, in an essential assessment of male fertility, other key factors should be taken into account. In this regard, the application of emerging artificial intelligence techniques may provide a unique opportunity to integrate all these parameters and deliver personalized care.PMID:38624205 | DOI:10.4103/aja20247 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Guillaume Bachelot Antonin Lamaziere Sebastien Czernichow Celine Faure Chrystelle Racine Rachel Levy Charlotte Dupont Nutrition and Fertility (ALIFERT) Group Source Type: research
Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer
This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). PubMed, EMBASE, and the Cochrane Library were comprehensively searched for eligible randomized controlled trials (RCTs) published from inception to October 2023. Interventions included abiraterone, apalutamide, enzalutamide, docetaxel, darolutamide, and androgen deprivation therapy (ADT), either as doublet or triplet therapies. The outcomes examined were overall survival (OS), progression-free survival (PFS), castration-resistant prostate cancer (CRPC)-free survival, time to symptomat...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Shan-Shan Wang Xiao-Jie Bian Jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei Ye Source Type: research
Transrectal versus transperineal prostate biopsy for cancer detection in patients with gray-zone prostate-specific antigen: a multicenter, real-world study
Asian J Androl. 2024 Apr 16. doi: 10.4103/aja20241. Online ahead of print.ABSTRACTKnowledge about the effect of different prostate biopsy approaches on the prostate cancer detection rate (CDR) in patients with gray-zone prostate-specific antigen (PSA) is limited. We performed this study to compare the CDR among patients who underwent different biopsy approaches and had rising PSA levels in the gray zone. Two hundred and twenty-two patients who underwent transrectal prostate biopsy (TRB) and 216 patients who underwent transperineal prostate biopsy (TPB) between June 2016 and September 2022 were reviewed in this study. In ad...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Jun-Xiao Liu Ze-Yuan Wang Shao-Xi Niu Xiao-Yong Sai Xu Zhang Xue-Pei Zhang Xin Ma Source Type: research
