The impact of temperature on vascular function in connection with vascular laser treatment
Lasers Med Sci. 2024 May 4;39(1):122. doi: 10.1007/s10103-024-04070-7.ABSTRACTPulsed dye lasers are used effectively in the treatment of psoriasis with long remission time and limited side effects. It is, however, not completely understood which biological processes underlie its favorable outcome. Pulsed dye laser treatment at 585-595 nm targets hemoglobin in the blood, inducing local hyperthermia in surrounding blood vessels and adjacent tissues. While the impact of destructive temperatures on blood vessels has been well studied, the effects of lower temperatures on the function of several cell types within the blood vess...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: M Doppegieter T G van Leeuwen M C G Aalders J de Vos E T van Bavel E N T P Bakker Source Type: research
miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signaling
CONCLUSION: These findings establish a therapeutic role for miR-369-3p in halting diabetes-associated atherosclerosis by regulating GPR91 and macrophage succinate metabolism.PMID:38703377 | DOI:10.1093/cvr/cvae102 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Shruti Rawal Vinay Randhawa Syed Husain Mustafa Rizvi Madhur Sachan Akm Khyrul Wara Daniel P érez-Cremades Robert M Weisbrod Naomi M Hamburg Mark W Feinberg Source Type: research
Atopic dermatitis is associated with an increased risk of cardiovascular diseases: A large-scale, propensity-matched US-based retrospective study
CONCLUSION: Atopic dermatitis is associated with an increased risk for multiple cardiovascular diseases.PMID:38703379 | DOI:10.1093/ced/llae164 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Henner Zirpel Sascha St änder Alicja Fr ączek Henning Olbrich Ralf J Ludwig Diamant Tha çi Source Type: research
Impact of loss-of-function in angiopoietin-like 4 on the human phenome
CONCLUSIONS: ANGPTL4 inhibition may represent a potentially safe and effective target for cardiometabolic diseases prevention or treatment.PMID:38703417 | DOI:10.1016/j.atherosclerosis.2024.117558 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Eloi Gagnon J érome Bourgault Émilie Gobeil S ébastien Thériault Benoit J Arsenault Source Type: research
Insulin resistance in the adipose tissue predicts future vascular resistance: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
CONCLUSIONS: Future vascular resistance was predicted by insulin resistance in the adipose tissue. After glucose intake, serum FFA levels may significantly impact vascular resistance development.PMID:38703418 | DOI:10.1016/j.atherosclerosis.2024.117547 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Nobuo Sasaki Yoshitaka Ueno Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research
Alterations in the gut mycobiome with coronary artery disease severity
In conclusion, the structure and composition of the gut fungal community differed from healthy controls to various subtypes of CAD, revealing key fungi taxa alterations linked to the onset and progression of CAD. Our study highlights the potential role of gut fungi in CAD and may facilitate the development of novel biomarkers and therapeutic targets for CAD.FUNDING: This work was supported by the grants from the National Natural Science Foundation of China (No. 82170302, 92168117, 82370432), National clinical key specialty construction project- Cardiovascular Surgery, the Reform and Development Program of Beijing Institute...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Kun An Yanxiong Jia Boqia Xie Jie Gao Yihang Chen Wen Yuan Jiuchang Zhong Pixiong Su Xiaoyan Liu Source Type: research
Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis
CONCLUSION: Hysterectomy, even with ovarian preservation, may be independently associated with a higher risk of metabolic syndrome. If other studies confirm these findings, screening and preventive strategies focused on females with ovary-sparing hysterectomy and the mechanisms underpinning these associations may be explored.PMID:38703940 | DOI:10.1016/j.ajog.2024.04.035 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Eric K Broni Justin B Echouffo Tcheugui Anna Palatnik Ernest M Graham Ruth-Alma Turkson-Ocran Yvonne Commodore-Mendah Chiadi E Ndumele Erin D Michos Source Type: research
The Association Between Adverse Cardiovascular Outcomes in Celiac Disease and the Role of Inflammation: Retrospective Analysis Using the National Inpatient Sample
Curr Probl Cardiol. 2024 May 2:102612. doi: 10.1016/j.cpcardiol.2024.102612. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease with patients being prone to a proinflammatory state. With recent studies showing an association between adverse cardiovascular events in patients with CD, we aim to further elucidate this relationship. Furthermore, when risk-stratifying patients with cardiovascular disease (CVD), chronic inflammatory conditions such as CD are not included in these calculations. We conducted a retrospective analysis using the National Inpatient Sample database from 2016 to 2019 to inve...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Rabab Elsadek Zeeshan Ismail Raghav Bassi Anuoluwa Oyetoran Yaseen Perbtani Tony Brar Suzanne Zentko Source Type: research
Incidence of recurrent ischemic stroke and its associated factors in a tertiary care center in Thailand: a retrospective cohort study
CONCLUSION: The incidence rate of the recurrence was moderate in our tertiary care setting, with a decreasing trend over time after the first episode. The various subtypes of IS and smoking status can lead to differences in event-free survival probabilities.PMID:38704525 | DOI:10.1186/s12883-024-03640-0 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Thanapoom Taweephol Pitsinee Saksit Akarin Hiransuthikul Pongpat Vorasayan Wasan Akarathanawat Aurauma Chutinet Source Type: research
The clinical role of combined circulating complement C1q and AIP for CAD with LDL-C level below 1.8mmol/L
CONCLUSIONS: In conclusion, there appears to be a notable positive correlation between the combination of C1q with the AIP and CAD.PMID:38704561 | DOI:10.1186/s12944-024-02127-8 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Chenyujun Hu Zehao Zhao Shutong Dong Qianyun Guo Yujie Zhou Source Type: research
Induction of Let-7d-5p miRNA modulates aortic smooth muscle inflammatory signaling and phenotypic switching.
Activation of vascular smooth muscle cell inflammation is recognised as an important early driver of vascular disease. We have previously identified the let-7 miRNA family as important regulators of inflammation in in vitro and in vivo models of atherosclerosis. Here we investigated a dual statin/let-7d-5p miRNA combination therapy approach to target human aortic SMC (HAoSMC) activation and inflammation. (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Tanwi Vartak, Elena Giardini, Daniel Kelly, Bruce Moran, Ciar án Kennedy, Mary Barry, Catherine Godson, Eoin Brennan Source Type: research
Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions
Front Immunol. 2024 Apr 18;15:1377470. doi: 10.3389/fimmu.2024.1377470. eCollection 2024.ABSTRACTAtherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory cells within the damaged walls of arterial vessels. It is a significant independent risk factor for ischemic cardiovascular disease, ischemic stroke, and peripheral arterial disease. Despite the availability of current treatments such as statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and lifestyle modifications for prevention, AS remains a leading cause of morbidity and ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Li Wang Shenyi Huang Xiaolun Liang Junliang Zhou Yifan Han Jiangshan He Danping Xu Source Type: research
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation
This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.PMID:38699583 | PMC:PMC11064802 | DOI:10.3389/fcvm.2024.1372055 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Yan Zhang Xue-Ying Zhang Shan-Rui Shi Chao-Nan Ma Yun-Peng Lin Wen-Gang Song Shou-Dong Guo Source Type: research
The first Japanese case with familial combined hypolipidemia without any complications caused by loss-of function variants in < em > ANGPTL3 < /em > : Case report
Heliyon. 2024 Apr 21;10(8):e29924. doi: 10.1016/j.heliyon.2024.e29924. eCollection 2024 Apr 30.ABSTRACTFamilial combined hypolipidemia, previously known as Familial hypobetalipoproteinemia 2 (FHBL2) is considered as an extremely rare recessive disease. Here, we present the case of familial combined hypolipidemia with homozygous loss-of function (LOF) variants in angiopoietin-like protein 3 (ANGPTL3) ((NM_014495.4) c.439_442del (p.Thr146_Asn147insTer)) using panel sequencing (46 yr male whose LDL cholesterol = 34 mg/dL). The serum level of ANGPTL3 was quite low (undetectable). Despite of extreme decreasing LDL cholesterol, ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Hayato Tada Nobuko Kojima Masa-Aki Kawashiri Masayuki Takamura Source Type: research
