Neural mechanisms of respiratory interoception
Auton Neurosci. 2024 Apr 25;253:103181. doi: 10.1016/j.autneu.2024.103181. Online ahead of print.ABSTRACTRespiratory interoception is one of the internal bodily systems that is comprised of different types of somatic and visceral sensations elicited by different patterns of afferent input and respiratory motor drive mediating multiple respiratory modalities. Respiratory interoception is a complex system, having multiple afferents grouped into afferent clusters and projecting into both discriminative and affective centers that are directly related to the behavioral assessment of breathing. The multi-afferent system provides...
Source: Autonomic Neuroscience - May 2, 2024 Category: Neuroscience Authors: Pei-Ying Sarah Chan Lu-Yuan Lee Paul W Davenport Source Type: research
Neural mechanisms of respiratory interoception
Auton Neurosci. 2024 Apr 25;253:103181. doi: 10.1016/j.autneu.2024.103181. Online ahead of print.ABSTRACTRespiratory interoception is one of the internal bodily systems that is comprised of different types of somatic and visceral sensations elicited by different patterns of afferent input and respiratory motor drive mediating multiple respiratory modalities. Respiratory interoception is a complex system, having multiple afferents grouped into afferent clusters and projecting into both discriminative and affective centers that are directly related to the behavioral assessment of breathing. The multi-afferent system provides...
Source: Autonomic Neuroscience - May 2, 2024 Category: Neuroscience Authors: Pei-Ying Sarah Chan Lu-Yuan Lee Paul W Davenport Source Type: research
Longitudinal prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative (PPMI) cohort
CONCLUSIONS: nOH prevalence was greater than non-nOH in the PPMI early PD cohort, with modest prevalence increase over time. Our findings are consistent with prior studies of large cohorts that evaluated nOH, specifically. Those with early PD and nOH were likelier to be older and suffer from greater motor and functional impairment, but OH presence was generally associated with more cognitive impairment.PMID:38692034 | DOI:10.1016/j.autneu.2024.103173 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - May 1, 2024 Category: Neuroscience Authors: Paul Beach J Lucas McKay Source Type: research
Longitudinal prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative (PPMI) cohort
CONCLUSIONS: nOH prevalence was greater than non-nOH in the PPMI early PD cohort, with modest prevalence increase over time. Our findings are consistent with prior studies of large cohorts that evaluated nOH, specifically. Those with early PD and nOH were likelier to be older and suffer from greater motor and functional impairment, but OH presence was generally associated with more cognitive impairment.PMID:38692034 | DOI:10.1016/j.autneu.2024.103173 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - May 1, 2024 Category: Neuroscience Authors: Paul Beach J Lucas McKay Source Type: research
Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry
Auton Neurosci. 2024 Apr 23;253:103179. doi: 10.1016/j.autneu.2024.103179. Online ahead of print.ABSTRACTUnilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 hea...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Peter D Drummond Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Voluntary wheel running as a promising strategy to promote autonomic resilience to social stress in females: Vagal tone lies at the heart of the matter
Auton Neurosci. 2024 Apr 15;253:103175. doi: 10.1016/j.autneu.2024.103175. Online ahead of print.ABSTRACTSocial stress is a major risk factor for comorbid conditions including cardiovascular disease and depression. While women exhibit 2-3× the risk for these stress-related disorders compared to men, the mechanisms underlying heightened stress susceptibility among females remain largely unknown. Due to a lack in understanding of the pathophysiology underlying stress-induced comorbidities among women, there has been a significant challenge in developing effective therapeutics. Recently, a causal role for inflammation has be...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Brittany S Pate Cora E Smiley Evelynn N Harrington B Hunter Bielicki J Mark Davis Lawrence P Reagan Claudia A Grillo Susan K Wood Source Type: research
Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry
Auton Neurosci. 2024 Apr 23;253:103179. doi: 10.1016/j.autneu.2024.103179. Online ahead of print.ABSTRACTUnilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 hea...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Peter D Drummond Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Voluntary wheel running as a promising strategy to promote autonomic resilience to social stress in females: Vagal tone lies at the heart of the matter
Auton Neurosci. 2024 Apr 15;253:103175. doi: 10.1016/j.autneu.2024.103175. Online ahead of print.ABSTRACTSocial stress is a major risk factor for comorbid conditions including cardiovascular disease and depression. While women exhibit 2-3× the risk for these stress-related disorders compared to men, the mechanisms underlying heightened stress susceptibility among females remain largely unknown. Due to a lack in understanding of the pathophysiology underlying stress-induced comorbidities among women, there has been a significant challenge in developing effective therapeutics. Recently, a causal role for inflammation has be...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Brittany S Pate Cora E Smiley Evelynn N Harrington B Hunter Bielicki J Mark Davis Lawrence P Reagan Claudia A Grillo Susan K Wood Source Type: research
Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry
Auton Neurosci. 2024 Apr 23;253:103179. doi: 10.1016/j.autneu.2024.103179. Online ahead of print.ABSTRACTUnilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 hea...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Peter D Drummond Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Voluntary wheel running as a promising strategy to promote autonomic resilience to social stress in females: Vagal tone lies at the heart of the matter
Auton Neurosci. 2024 Apr 15;253:103175. doi: 10.1016/j.autneu.2024.103175. Online ahead of print.ABSTRACTSocial stress is a major risk factor for comorbid conditions including cardiovascular disease and depression. While women exhibit 2-3× the risk for these stress-related disorders compared to men, the mechanisms underlying heightened stress susceptibility among females remain largely unknown. Due to a lack in understanding of the pathophysiology underlying stress-induced comorbidities among women, there has been a significant challenge in developing effective therapeutics. Recently, a causal role for inflammation has be...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Brittany S Pate Cora E Smiley Evelynn N Harrington B Hunter Bielicki J Mark Davis Lawrence P Reagan Claudia A Grillo Susan K Wood Source Type: research
Tributyltin (TBT) toxicity: Effects on enteric neuronal plasticity and intestinal barrier of rats' duodenum
Auton Neurosci. 2024 Apr 18;253:103176. doi: 10.1016/j.autneu.2024.103176. Online ahead of print.ABSTRACTTributyltin (TBT) is a biocide used in the formulation of antifouling paints and it is highly harmful. Despite the ban, the compound persists in the environment, contaminating marine foodstuffs and household products. Therefore, considering the route of exposure to the contaminant, the gastrointestinal tract (GIT) acts as an important barrier against harmful substances and is a potential biomarker for understanding the consequences of these agents. This work aimed to evaluate histological and neuronal alterations in the...
Source: Autonomic Neuroscience - April 26, 2024 Category: Neuroscience Authors: I C C S Oliveira G P Marinsek L V B Correia R C B da Silva I B Castro R B Mari Source Type: research
Tributyltin (TBT) toxicity: Effects on enteric neuronal plasticity and intestinal barrier of rats' duodenum
Auton Neurosci. 2024 Apr 18;253:103176. doi: 10.1016/j.autneu.2024.103176. Online ahead of print.ABSTRACTTributyltin (TBT) is a biocide used in the formulation of antifouling paints and it is highly harmful. Despite the ban, the compound persists in the environment, contaminating marine foodstuffs and household products. Therefore, considering the route of exposure to the contaminant, the gastrointestinal tract (GIT) acts as an important barrier against harmful substances and is a potential biomarker for understanding the consequences of these agents. This work aimed to evaluate histological and neuronal alterations in the...
Source: Autonomic Neuroscience - April 26, 2024 Category: Neuroscience Authors: I C C S Oliveira G P Marinsek L V B Correia R C B da Silva I B Castro R B Mari Source Type: research
