Correction: Empaglifozin improves kidney senescence induced by D-galactose by reducing sirt1-mediated oxidative stress
Biogerontology. 2024 Apr 26. doi: 10.1007/s10522-024-10108-8. Online ahead of print.NO ABSTRACTPMID:38668818 | DOI:10.1007/s10522-024-10108-8 (Source: Biogerontology)
Source: Biogerontology - April 26, 2024 Category: Geriatrics Authors: Ronghua Fang Jie Chen Jiangchuan Long Binghan Zhang Qixuan Huang Shengbing Li Ke Li Qing Chen Dongfang Liu Source Type: research
Correction: Empaglifozin improves kidney senescence induced by D-galactose by reducing sirt1-mediated oxidative stress
Biogerontology. 2024 Apr 26. doi: 10.1007/s10522-024-10108-8. Online ahead of print.NO ABSTRACTPMID:38668818 | DOI:10.1007/s10522-024-10108-8 (Source: Biogerontology)
Source: Biogerontology - April 26, 2024 Category: Geriatrics Authors: Ronghua Fang Jie Chen Jiangchuan Long Binghan Zhang Qixuan Huang Shengbing Li Ke Li Qing Chen Dongfang Liu Source Type: research
Correction: Empaglifozin improves kidney senescence induced by D-galactose by reducing sirt1-mediated oxidative stress
Biogerontology. 2024 Apr 26. doi: 10.1007/s10522-024-10108-8. Online ahead of print.NO ABSTRACTPMID:38668818 | DOI:10.1007/s10522-024-10108-8 (Source: Biogerontology)
Source: Biogerontology - April 26, 2024 Category: Geriatrics Authors: Ronghua Fang Jie Chen Jiangchuan Long Binghan Zhang Qixuan Huang Shengbing Li Ke Li Qing Chen Dongfang Liu Source Type: research
Correction: Empaglifozin improves kidney senescence induced by D-galactose by reducing sirt1-mediated oxidative stress
Biogerontology. 2024 Apr 26. doi: 10.1007/s10522-024-10108-8. Online ahead of print.NO ABSTRACTPMID:38668818 | DOI:10.1007/s10522-024-10108-8 (Source: Biogerontology)
Source: Biogerontology - April 26, 2024 Category: Geriatrics Authors: Ronghua Fang Jie Chen Jiangchuan Long Binghan Zhang Qixuan Huang Shengbing Li Ke Li Qing Chen Dongfang Liu Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10104-y. Online ahead of print.ABSTRACTPolyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) possesses anti-aging properties in Saccharomyces cerevisiae BY611 yeast cells. Building on these findings, this study delves deeper into the potential antiaging mechanism of PLME, by analyzing the transcriptional responses of BY611 cells treated with PLME using RNA-sequencing (RNA-seq) technology. The RNA-seq analysis results...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Manisekaran Hemagirri Yeng Chen Subash C B Gopinath Mohd Adnan Mitesh Patel Sreenivasan Sasidharan Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10104-y. Online ahead of print.ABSTRACTPolyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) possesses anti-aging properties in Saccharomyces cerevisiae BY611 yeast cells. Building on these findings, this study delves deeper into the potential antiaging mechanism of PLME, by analyzing the transcriptional responses of BY611 cells treated with PLME using RNA-sequencing (RNA-seq) technology. The RNA-seq analysis results...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Manisekaran Hemagirri Yeng Chen Subash C B Gopinath Mohd Adnan Mitesh Patel Sreenivasan Sasidharan Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10104-y. Online ahead of print.ABSTRACTPolyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) possesses anti-aging properties in Saccharomyces cerevisiae BY611 yeast cells. Building on these findings, this study delves deeper into the potential antiaging mechanism of PLME, by analyzing the transcriptional responses of BY611 cells treated with PLME using RNA-sequencing (RNA-seq) technology. The RNA-seq analysis results...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Manisekaran Hemagirri Yeng Chen Subash C B Gopinath Mohd Adnan Mitesh Patel Sreenivasan Sasidharan Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
