High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, includin... (Source: Biological Research)
Source: Biological Research - May 6, 2024 Category: Biomedical Science Authors: Sylvana I. S. Rendeiro de Noronha, Lauro Angelo Gon çalves de Moraes, James E. Hassell Jr., Christopher E. Stamper, Mathew R. Arnold, Jared D. Heinze, Christine L. Foxx, Margaret M. Lieb, Kristin E. Cler, Bree L. Karns, Sophia Jaekel, Kelsey M. Loupy, Fe Tags: Research article Source Type: research
Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and appl... (Source: Biological Research)
Source: Biological Research - May 6, 2024 Category: Biomedical Science Authors: Binan Zhao, Haoran Peng, Yanjing Zhang, Jie Zhang, Desheng Kong, Sai Cao, Yan Li, Dan Yang, Chuanwen Sun, Xinyi Pu, Ping Zhao, Yan Xu, Kai Zhao and Liangzhi Xie Tags: Research article Source Type: research
Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach
Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression. Establishment of cancer cell lines derived from... (Source: Biological Research)
Source: Biological Research - May 4, 2024 Category: Biomedical Science Authors: Simon Lange, Anna Kuntze, Neele W üstmann, Theresa Reckers, Verena Humberg, Wilhelm G. Dirks, Sebastian Huss, Julia Vieler, Andres Jan Schrader, Martin Bögemann, Katrin Schlack and Christof Bernemann Tags: Research article Source Type: research
General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex
Chromatin dynamics is deeply involved in processes that require access to DNA, such as transcriptional regulation. Among the factors involved in chromatin dynamics at gene regulatory regions are general regula... (Source: Biological Research)
Source: Biological Research - May 4, 2024 Category: Biomedical Science Authors: Andrea Oyarz ún-Cisterna, Cristián Gidi, Fernanda Raiqueo, Roberto Amigo, Camila Rivas, Marcela Torrejón and José L. Gutiérrez Tags: Research article Source Type: research
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure... (Source: Biological Research)
Source: Biological Research - May 2, 2024 Category: Biomedical Science Authors: Omar I. Badr, Mohamed M. Kamal, Shohda A. El-Maraghy and Heba R. Ghaiad Tags: Research article Source Type: research
Control of astrocytic Ca2+ signaling by nitric oxide-dependent S-nitrosylation of Ca2+ homeostasis modulator 1 channels
Astrocytes Ca2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate released during an increase in synaptic activity triggers ... (Source: Biological Research)
Source: Biological Research - April 30, 2024 Category: Biomedical Science Authors: Mariela Puebla, Manuel F. Mu ñoz, Mauricio A. Lillo, Jorge E. Contreras and Xavier F. Figueroa Tags: Research article Source Type: research
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordi... (Source: Biological Research)
Source: Biological Research - April 27, 2024 Category: Biomedical Science Authors: Yaiza M. Arenas, Adri à López-Gramaje, Carmina Montoliu, Marta Llansola and Vicente Felipo Tags: Research article Source Type: research
Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel (Mytilus chilensis)
Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted between individuals and can also be induced by external chemical agents su... (Source: Biological Research)
Source: Biological Research - April 26, 2024 Category: Biomedical Science Authors: Gloria Arriagada, Johan Quezada, Nicolas Merino-Veliz, Fernando Avil és, Diana Tapia-Cammas, Jorge Gomez, Daniela Curotto, Juan A. Valdes, Pablo A. Oyarzún, Cristian Gallardo-Escárate, Michael J. Metzger and Marco Alvarez Tags: Research article Source Type: research
Noncoding RNAs in skeletal development and disorders
Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of app... (Source: Biological Research)
Source: Biological Research - April 22, 2024 Category: Biomedical Science Authors: Qing Yao, Tailin He, Jian-You Liao, Rongdong Liao, Xiaohao Wu, Lijun Lin and Guozhi Xiao Tags: Review Source Type: research
Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subc... (Source: Biological Research)
Source: Biological Research - April 4, 2024 Category: Biomedical Science Authors: Elisa Perez-Moreno, Claudia Oyanadel, Adely de la Pe ña, Ronny Hernández, Francisca Pérez-Molina, Claudia Metz, Alfonso González and Andrea Soza Tags: Review Source Type: research
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that... (Source: Biological Research)
Source: Biological Research - April 4, 2024 Category: Biomedical Science Authors: Gonzalo I. G ómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz and Juan A. Tags: Research article Source Type: research
The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans
Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the... (Source: Biological Research)
Source: Biological Research - April 1, 2024 Category: Biomedical Science Authors: Laura Rodr íguez-Castro, Roberto E. Durán, Valentina Méndez, Flavia Dorochesi, Daniela Zühlke, Katharina Riedel and Michael Seeger Tags: Research article Source Type: research
Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function
Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic... (Source: Biological Research)
Source: Biological Research - April 1, 2024 Category: Biomedical Science Authors: Pei Chen, Chaoshuang Ye, Yunke Huang, Bingning Xu, Tianyu Wu, Yuanhang Dong, Yang Jin, Li Zhao, Changchang Hu, Jingxia Mao and Ruijin Wu Tags: Research article Source Type: research
MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal... (Source: Biological Research)
Source: Biological Research - March 23, 2024 Category: Biomedical Science Authors: Karina Ca ñón-Beltrán, Yulia N Cajas, Vasileios Almpanis, Sandra Guisado Egido, Alfonso Gutierrez-Adan, Encina M González and Dimitrios Rizos Tags: Research article Source Type: research
YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions
The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT... (Source: Biological Research)
Source: Biological Research - March 17, 2024 Category: Biomedical Science Authors: Yuanyuan Luo, Lingxiao Zhang, Ning Su, Lerong Liu and Tongfeng Zhao Tags: Research article Source Type: research
