UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells
Ubiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to describe its role in prostate cancer. The purpose of this paper is to ... (Source: Biology Direct)
Source: Biology Direct - May 7, 2024 Category: Biology Authors: Bo Yang, Weihua Chen, Tianyi Tao, Jun Zhang, Dehui Kong, Jidong Hao, Chao Yu, Guoqiang Liao and Hua Gong Tags: Research Source Type: research
CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1 α-mediated glycometabolism alteration
Epidermal growth factor receptor (EGFR)-targeted therapy is an important treatment for RAS wild-type metastatic colorectal cancer (mCRC), but the resistance mechanism remains unclear. Here, the differential ex... (Source: Biology Direct)
Source: Biology Direct - May 7, 2024 Category: Biology Authors: Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu and Wenwei Hu Tags: Research Source Type: research
LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer
LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer. (Source: Biology Direct)
Source: Biology Direct - May 2, 2024 Category: Biology Authors: Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang, Qinwei Xu, Junyi Han and Bing Lu Tags: Research Source Type: research
Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight
The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis... (Source: Biology Direct)
Source: Biology Direct - April 30, 2024 Category: Biology Authors: Mingqi Zhou, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Robert J. Ferl and Anna-Lisa Paul Tags: Research Source Type: research
NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury
This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism. (Source: Biology Direct)
Source: Biology Direct - April 29, 2024 Category: Biology Authors: Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang and Yan Ding Tags: Research Source Type: research
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC).... (Source: Biology Direct)
Source: Biology Direct - April 24, 2024 Category: Biology Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu Tags: Research Source Type: research
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging
Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the declined oocytes showing with organelle dysfunction and oxidative stress... (Source: Biology Direct)
Source: Biology Direct - April 23, 2024 Category: Biology Authors: Lin-Lin Hu, Mei-Hua Liao, Ya-Xi Liu, Chun-Hua Xing, Lan-Lan Nong, Feng-Lian Yang and Shao-Chen Sun Tags: Research Source Type: research
Biomimetic peroxidase MOF-Fe promotes bone defect repair by inhibiting TfR2 and activating the BMP2 pathway
Large bone defects pose a clinical treatment challenge; inhibiting transferrin receptor 2 (TfR2), which is involved in iron metabolism, can promote osteogenesis. Iron-based metal-organic frameworks (MOF-Fe) pa... (Source: Biology Direct)
Source: Biology Direct - April 23, 2024 Category: Biology Authors: Yaxin Xue, Wei Xu, Danyang Zhao, Zijing Du, Hao Jiang, Hao Lv, Dong Zhang, Zhencheng Yu, Yi Cao and Dong Han Tags: Research Source Type: research
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway
Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Kr üppel C2H2 zinc ... (Source: Biology Direct)
Source: Biology Direct - April 22, 2024 Category: Biology Authors: Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu and Weichun Guo Tags: Research Source Type: research
Correction: Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway
(Source: Biology Direct)
Source: Biology Direct - April 18, 2024 Category: Biology Authors: Du Shen and Shaosan Kang Tags: Correction Source Type: research
Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity
Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an earl... (Source: Biology Direct)
Source: Biology Direct - April 6, 2024 Category: Biology Authors: Mario Villa-Gonz ález, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell and Maria José Pérez-Álvarez Tags: Research Source Type: research
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p
Circular RNAs (circRNAs) are a class of highly multifunctional single-stranded RNAs that play crucial roles in cancer progression, including osteosarcoma (OS). Circ_0002669, generated from the dedicator of cyt... (Source: Biology Direct)
Source: Biology Direct - April 3, 2024 Category: Biology Authors: Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu and Chuangzhen Chen Tags: Research Source Type: research
LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4
Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but ... (Source: Biology Direct)
Source: Biology Direct - March 19, 2024 Category: Biology Authors: Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou and Chuanzhao Zhang Tags: Research Source Type: research
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling
This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved. (Source: Biology Direct)
Source: Biology Direct - March 18, 2024 Category: Biology Authors: Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu and Xiaojing Li Tags: Research Source Type: research
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance
Neutral/alkaline invertases (N/AINVs) play a crucial role in plant growth, development, and stress response, by irreversibly hydrolyzing sucrose into glucose and fructose. However, research on cotton in this a... (Source: Biology Direct)
Source: Biology Direct - March 14, 2024 Category: Biology Authors: Kaikai Qiao, Qingtao Zeng, Jiaoyan Lv, Lingling Chen, Juxin Hao, Ding Wang, Qifeng Ma and Shuli Fan Tags: Research Source Type: research
