Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.4c00241. Online ahead of print.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglita...
Source: Biomacromolecules - April 30, 2024 Category: Biochemistry Authors: Yujie Xiao Yinghui Xu Xianda Liu Shengjun Cheng Ran Wei Weifeng Zhao Changsheng Zhao Source Type: research
Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids
Biomacromolecules. 2024 Apr 29. doi: 10.1021/acs.biomac.4c00117. Online ahead of print.ABSTRACTNucleic acid therapeutics have attracted recent attention as promising preventative solutions for a broad range of diseases. Nonviral delivery vectors, such as cationic polymers, improve the cellular uptake of nucleic acids without suffering the drawbacks of viral delivery vectors. However, these delivery systems are faced with a major challenge for worldwide deployment, as their poor thermal stability elicits the need for cold chain transportation. Here, we demonstrate a biomaterial strategy to drastically improve the thermal st...
Source: Biomacromolecules - April 29, 2024 Category: Biochemistry Authors: Yiyan Chen Xiaoyan Lin Xuhan Liu Yifan Liu Liem Bui-Le Anna K Blakney Jonathan Yeow Yunqing Zhu Molly M Stevens Robin J Shattock Rongjun Chen Alex P S Brogan Jason P Hallett Source Type: research
DNA Released by Adeno-Associated Virus Strongly Alters Capsid Aggregation Kinetics in a Physiological Solution
Biomacromolecules. 2024 Apr 29. doi: 10.1021/acs.biomac.4c00027. Online ahead of print.ABSTRACTWhile adeno-associated virus is a leading vector for gene therapy, significant gaps remain in understanding AAV degradation and stability. In this work, we study the degradation of an engineered AAV serotype at physiological pH and ionic strength. Viral particles of varying fractions of encapsulated DNA were incubated between 30 and 60 °C, with changes in molecular weight measured by changes in total light scattering intensity at 90° over time. Mostly full vectors demonstrated a rapid decrease in molecular weight corresponding ...
Source: Biomacromolecules - April 29, 2024 Category: Biochemistry Authors: Curtis W Jarand Karen Baker Matthew Petroff Mi Jin Wayne F Reed Source Type: research
Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment
Biomacromolecules. 2024 Apr 29. doi: 10.1021/acs.biomac.4c00300. Online ahead of print.ABSTRACTAchieving precise control over gelator alignment and morphology is crucial for crafting tailored materials and supramolecular structures with distinct properties. We successfully aligned the self-assembled micelles formed by a functionalized dipeptide 2NapFF into long 1-D "gel noodles" by cross-linking with divalent metal chlorides. We identify the most effective cross-linker for alignment, enhancing mechanical stability, and imparting functional properties. Our study shows that Group 2 metal ions are particularly suited for crea...
Source: Biomacromolecules - April 29, 2024 Category: Biochemistry Authors: Dipankar Ghosh Sophie M Coulter Garry Laverty Chris Holland James J Doutch Massimo Vassalli Dave J Adams Source Type: research
Novel Type of Slowly Digested Starch Complex with Antioxidant Properties
This study demonstrates that these novel starch-gingerol complexes have the potential to deliver antioxidants encapsulated in starch with slow-digesting properties and reduce oxidative stress. Moreover, this new type of slowly digested starch with antioxidant properties showed great potential in the prevention of type 2 diabetes.PMID:38676646 | DOI:10.1021/acs.biomac.4c00030 (Source: Biomacromolecules)
Source: Biomacromolecules - April 27, 2024 Category: Biochemistry Authors: Huilan Zhu Cuiping Wang Yujue Wang Jinglin Yu Les Copeland Shujun Wang Source Type: research
Novel Type of Slowly Digested Starch Complex with Antioxidant Properties
This study demonstrates that these novel starch-gingerol complexes have the potential to deliver antioxidants encapsulated in starch with slow-digesting properties and reduce oxidative stress. Moreover, this new type of slowly digested starch with antioxidant properties showed great potential in the prevention of type 2 diabetes.PMID:38676646 | DOI:10.1021/acs.biomac.4c00030 (Source: Biomacromolecules)
Source: Biomacromolecules - April 27, 2024 Category: Biochemistry Authors: Huilan Zhu Cuiping Wang Yujue Wang Jinglin Yu Les Copeland Shujun Wang Source Type: research
Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy
In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded with the IDO inhibitor NLG919 for a dual application involving PDT and immunotherapy (PRGD/NLG919). In vitro experiments revealed the heightened cellular uptake of PRGD/NLG919 nanosheets in tumor cells overexpressing αvβ3 integrins. The pH-responsive PRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generation and photocytotoxicity in HeLa cells in an acidic tumor microenvironment. When treating HeLa cells with PRGD/NLG919 nanosheets followed by laser irradiation, a more robust adap...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Bingbing Sun Haowen Yang Yudong Li Jari F Scheerstra Marleen H M E van Stevendaal Shukun Li Jan C M van Hest Source Type: research
Supramolecular Assembly and Thermogelation Strategies Using Peptide-Polymer Conjugates
Biomacromolecules. 2024 Apr 25. doi: 10.1021/acs.biomac.4c00031. Online ahead of print.ABSTRACTPeptide-polymer conjugates (PPCs) are of particular interest in the development of responsive, adaptive, and interactive materials due to the benefits offered by combining both building blocks and components. This review presents pioneering work as well as recent advances in the design of peptide-polymer conjugates, with a specific focus on their thermoresponsive behavior. This unique class of materials has shown great promise in the development of supramolecular structures with physicochemical properties that are modulated using...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Chlo é Pascouau Maren Schweitzer Pol Besenius Source Type: research
Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy
In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded with the IDO inhibitor NLG919 for a dual application involving PDT and immunotherapy (PRGD/NLG919). In vitro experiments revealed the heightened cellular uptake of PRGD/NLG919 nanosheets in tumor cells overexpressing αvβ3 integrins. The pH-responsive PRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generation and photocytotoxicity in HeLa cells in an acidic tumor microenvironment. When treating HeLa cells with PRGD/NLG919 nanosheets followed by laser irradiation, a more robust adap...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Bingbing Sun Haowen Yang Yudong Li Jari F Scheerstra Marleen H M E van Stevendaal Shukun Li Jan C M van Hest Source Type: research
Supramolecular Assembly and Thermogelation Strategies Using Peptide-Polymer Conjugates
Biomacromolecules. 2024 Apr 25. doi: 10.1021/acs.biomac.4c00031. Online ahead of print.ABSTRACTPeptide-polymer conjugates (PPCs) are of particular interest in the development of responsive, adaptive, and interactive materials due to the benefits offered by combining both building blocks and components. This review presents pioneering work as well as recent advances in the design of peptide-polymer conjugates, with a specific focus on their thermoresponsive behavior. This unique class of materials has shown great promise in the development of supramolecular structures with physicochemical properties that are modulated using...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Chlo é Pascouau Maren Schweitzer Pol Besenius Source Type: research
Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy
In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded with the IDO inhibitor NLG919 for a dual application involving PDT and immunotherapy (PRGD/NLG919). In vitro experiments revealed the heightened cellular uptake of PRGD/NLG919 nanosheets in tumor cells overexpressing αvβ3 integrins. The pH-responsive PRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generation and photocytotoxicity in HeLa cells in an acidic tumor microenvironment. When treating HeLa cells with PRGD/NLG919 nanosheets followed by laser irradiation, a more robust adap...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Bingbing Sun Haowen Yang Yudong Li Jari F Scheerstra Marleen H M E van Stevendaal Shukun Li Jan C M van Hest Source Type: research
Supramolecular Assembly and Thermogelation Strategies Using Peptide-Polymer Conjugates
Biomacromolecules. 2024 Apr 25. doi: 10.1021/acs.biomac.4c00031. Online ahead of print.ABSTRACTPeptide-polymer conjugates (PPCs) are of particular interest in the development of responsive, adaptive, and interactive materials due to the benefits offered by combining both building blocks and components. This review presents pioneering work as well as recent advances in the design of peptide-polymer conjugates, with a specific focus on their thermoresponsive behavior. This unique class of materials has shown great promise in the development of supramolecular structures with physicochemical properties that are modulated using...
Source: Biomacromolecules - April 25, 2024 Category: Biochemistry Authors: Chlo é Pascouau Maren Schweitzer Pol Besenius Source Type: research
A Review of Current Achievements and Recent Challenges in Bacterial Medium-Chain-Length Polyhydroxyalkanoates: Production and Potential Applications
In conclusion, this review serves as a valuable resource to understand mcl-PHAs as sustainable alternatives to conventional plastics. However, further research is needed to optimize production methods, evaluate long-term ecological impacts, and assess the feasibility and viability in various industries.PMID:38656151 | DOI:10.1021/acs.biomac.4c00090 (Source: Biomacromolecules)
Source: Biomacromolecules - April 24, 2024 Category: Biochemistry Authors: Nahid Azizi Reza Eslami Shaghayegh Goudarzi Habibollah Younesi Hadis Zarrin Source Type: research
A Review of Current Achievements and Recent Challenges in Bacterial Medium-Chain-Length Polyhydroxyalkanoates: Production and Potential Applications
In conclusion, this review serves as a valuable resource to understand mcl-PHAs as sustainable alternatives to conventional plastics. However, further research is needed to optimize production methods, evaluate long-term ecological impacts, and assess the feasibility and viability in various industries.PMID:38656151 | DOI:10.1021/acs.biomac.4c00090 (Source: Biomacromolecules)
Source: Biomacromolecules - April 24, 2024 Category: Biochemistry Authors: Nahid Azizi Reza Eslami Shaghayegh Goudarzi Habibollah Younesi Hadis Zarrin Source Type: research
Enzyme-Triggered Polyelectrolyte Complex for Responsive Delivery of α-Helical Polypeptides to Optimize Antibacterial Therapy
In this study, we present an enzyme-responsive polyelectrolyte complex micelles (PTPMN) with α-helical cationic polypeptide as a coacervate-core for the treatment of Escherichia coli (E. coli) infection. The complex was constructed through electrostatic interaction between cationic poly(glutamic acid) derivatives and phosphorylation-modified poly(ethylene glycol)-b-poly(tyrosine) (PEG-b-PPTyr) by directly dissolving them in aqueous solution. The cationic polypeptide adopted α-helical structure and demonstrated excellent broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria, with a mi...
Source: Biomacromolecules - April 23, 2024 Category: Biochemistry Authors: Liuxuan Li Ruoxue Wang Bo Zhao Bowen Yin Huijuan Zhang Chunyong Liang Xiuli Hu Source Type: research
