Association of cardiac biomarkers with long-term cardiovascular events in a community cohort
DISCUSSION: Ceramide score and NT proBNP improve the prediction of MACE and stroke/MI in a community primary prevention cohort.PMID:38666319 | DOI:10.1080/1354750X.2024.2335245 (Source: Biomarkers)
Source: Biomarkers - April 26, 2024 Category: Research Authors: Robert A Churchill Benjamin R Gochanour Christopher G Scott Vlad C Vasile Richard J Rodeheffer Jeffrey W Meeusen Allan S Jaffe Source Type: research
< em > BCAT1 < /em > , < em > IKZF1 < /em > and < em > SEPT9 < /em > : methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas
DISCUSSION: Existing CRC methylated ctDNA blood tests for BCAT1/IKZF1 and SEPT9 might be usefully repurposed for use in other gastrointestinal adenocarcinomas and warrant further prospective ctDNA studies.PMID:38644767 | DOI:10.1080/1354750X.2024.2340663 (Source: Biomarkers)
Source: Biomarkers - April 22, 2024 Category: Research Authors: Geraldine Laven-Law Ganessan Kichenadasse Graeme P Young Erin L Symonds Jean M Winter Source Type: research
A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma
CONCLUSION: This study successfully built a prognostic model of lactate metabolism and transport-related lncRNAs in GA. The findings guide prognostic management of GA patients.PMID:38629165 | DOI:10.1080/1354750X.2024.2341411 (Source: Biomarkers)
Source: Biomarkers - April 17, 2024 Category: Research Authors: Zhenyuan Qian Fang Wu Guoqing Feng Wenfa Lin Xufan Cai Jianzhang Wu Kun Ke Zaiyuan Ye Guoxi Xu Source Type: research
Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry
DiscussionBiomarkers may guide drug developers in selecting the optimal projects to progress, when designing clinical studies and development paths. Biomarkers may aid in the diagnosis and prognostic assessment of patients and assist in matching the molecular endotype to the selected treatment, which improves the success rate of clinical development progression. The aim of this paper is to provide a comprehensive ideation framework for how to utilize biomarkers in clinical development, with a focus on utility for patients, payers and drug developers.PMID:38606909 | DOI:10.1080/1354750X.2024.2342016 (Source: Biomarkers)
Source: Biomarkers - April 12, 2024 Category: Research Authors: Alexander L Reese-Petersen Helene W Breisnes Daniel Gabor Sarah R R ønnow Bruna Manoel Mayuur Bajaj Claus S von Arenstorff Elijah Aighobahi Rune Vestermark Morten A Karsdal Source Type: research
The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation
Conclusion: In patients with severe aortic stenosis undergoing transfemoral TAVI, MMP-2, and to a lesser extent Gal-3, seem to have additive value in optimizing risk prediction and streamlining decision-making.PMID:38588595 | DOI:10.1080/1354750X.2024.2341409 (Source: Biomarkers)
Source: Biomarkers - April 8, 2024 Category: Research Authors: Kerstin Piayda Julian Tim Heilemann Stanislav Keranov Luisa Schulz Mani Arsalan Christoph Liebetrau Won-Keun Kim Felix J Hofmann Pascal Bauer Sandra Voss Christian Troidl Samuel T Sossalla Christian W Hamm Holger M Nef Oliver D örr Source Type: research
