A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy
Biomaterials. 2024 Apr 21;309:122574. doi: 10.1016/j.biomaterials.2024.122574. Online ahead of print.ABSTRACTAs an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis ampli...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Mengyao Chen Xiaohan Tong Yanting Sun Chunyan Dong Chen Li Chunhui Wang Minyi Zhang Yixuan Wen Pinting Ye Ruihao Li Jie Wan Shujing Liang Shuo Shi Source Type: research
Wireless breathable face mask sensor for spatiotemporal 2D respiration profiling and respiratory diagnosis
In this study, we introduced an air-permeable, stretchable, and a pixelated pressure sensor that can be integrated into a commercial face mask. The mask sensor showed a strain-independent pressure-sensing performance, providing 2D pressure profiles for exhalation and inhalation. Real-time 2D respiration profiles could monitor various respiratory behaviors, such as oral/nasal breathing, clogged nose, out-of-breath, and coughing. Furthermore, they could detect respiratory diseases, such as rhinitis, sleep apnea, and pneumonia. The 2D respiratory profiling mask sensor is expected to be employed for remote respiration monitori...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Jaehyun Kim Heesung Roh Sungmin Moon Cheonhoo Jeon Seunggoo Baek Woosung Cho Jae-Yoon Sim Unyong Jeong Source Type: research
Corrigendum to 'Engineered cell-laden human protein-based elastomer' [34 (2013), 5496-5505]
Biomaterials. 2024 Apr 24:122572. doi: 10.1016/j.biomaterials.2024.122572. Online ahead of print.NO ABSTRACTPMID:38664162 | DOI:10.1016/j.biomaterials.2024.122572 (Source: Biomaterials)
Source: Biomaterials - April 25, 2024 Category: Materials Science Authors: Nasim Annabi Suzanne M Mithieux Pinar Zorlutuna Gulden Camci-Unal Anthony S Weiss Ali Khademhosseini Source Type: research
Corrigendum to 'Engineered cell-laden human protein-based elastomer' [34 (2013), 5496-5505]
Biomaterials. 2024 Apr 24:122572. doi: 10.1016/j.biomaterials.2024.122572. Online ahead of print.NO ABSTRACTPMID:38664162 | DOI:10.1016/j.biomaterials.2024.122572 (Source: Biomaterials)
Source: Biomaterials - April 25, 2024 Category: Materials Science Authors: Nasim Annabi Suzanne M Mithieux Pinar Zorlutuna Gulden Camci-Unal Anthony S Weiss Ali Khademhosseini Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Biomaterials. 2024 Apr 15;308:122571. doi: 10.1016/j.biomaterials.2024.122571. Online ahead of print.ABSTRACTThe abuse and overuse of antibiotics let drug-resistant bacteria emerges. Antibacterial photodynamic therapy (APDT) has shown outstanding merits to eliminate the drug-resistant bacteria via cytotoxic reactive oxygen species produced by irradiating photosensitizer. However, most of photosensitizers are not effective for Gram-negative bacteria elimination. Herein conjugates of NBS, a photosensitizer, linked with one (NBS-DPA-Zn) or two (NBS-2DPA-Zn) equivalents of zinc-dipicolylamine (Zn-DPA) have been designed to ach...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Zuokai Wang Shuang Zeng Yifu Hao Wenlin Cai Wen Sun Jianjun Du Saran Long Jiangli Fan Jingyun Wang Xiaoqiang Chen Xiaojun Peng Source Type: research
NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN- γ released
Biomaterials. 2024 Apr 15;308:122570. doi: 10.1016/j.biomaterials.2024.122570. Online ahead of print.ABSTRACTMetallic biomaterials activate tumor ferroptosis by increasing oxidative stress, but their efficacy is severely limited in tumor microenvironment. Although interferon gamma (IFN-γ) can promote tumor ferroptosis sensitivity by inhibiting the antioxidant system and promoting lipid accumulation, this effect limited by the lack of IFN-γ accumulation in tumors. Herein, we report a near-infrared (NIR)-responsive HCuS nanocomposite (HCuS-PE@TSL-tlyp-1) that can stimulate immunogenic cell death (ICD)-mediated IFN-γ secre...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Junrui Wang Wenli Zhang Zhuoyan Xie Xingyue Wang Jiangshan Sun Fei Ran Weixi Jiang Yun Liu Zhigang Wang Haitao Ran Dajing Guo Source Type: research
