Biomechanics and Modeling in Mechanobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Myocardial biomechanical effects of fetal aortic valvuloplasty
Biomech Model Mechanobiol. 2024 Apr 29. doi: 10.1007/s10237-024-01848-0. Online ahead of print.ABSTRACTFetal critical aortic stenosis with evolving hypoplastic left heart syndrome (CAS-eHLHS) can progress to a univentricular (UV) birth malformation. Catheter-based fetal aortic valvuloplasty (FAV) can resolve stenosis and reduce the likelihood of malformation progression. However, we have limited understanding of the biomechanical impact of FAV and subsequent LV responses. Therefore, we performed image-based finite element (FE) modeling of 4 CAS-eHLHS fetal hearts, by performing iterative simulations to match image-based ch...
Source: Biomechanics and Modeling in Mechanobiology - April 29, 2024 Category: Biomedical Science Authors: Laura Green Wei Xuan Chan Andreas Tulzer Gerald Tulzer Choon Hwai Yap Source Type: research

Study on the biodynamic characteristics and internal vibration behaviors of a seated human body under biomechanical characteristics
Biomech Model Mechanobiol. 2024 Apr 26. doi: 10.1007/s10237-024-01849-z. Online ahead of print.ABSTRACTTo provide reference and theoretical guidance for establishing human body dynamics models and studying biomechanical vibration behavior, this study aimed to develop and verify a computational model of a three-dimensional seated human body with detailed anatomical structure under complex biomechanical characteristics to investigate dynamic characteristics and internal vibration behaviors of the human body. Fifty modes of a seated human body were extracted by modal method. The intervertebral disc and head motions under unia...
Source: Biomechanics and Modeling in Mechanobiology - April 26, 2024 Category: Biomedical Science Authors: RuiChun Dong Shuai Zhu Xiang Cheng Xiang Gao ZhongLong Wang Yi Wang Source Type: research

Validation of a computational biomechanical mouse brain model for rotational head acceleration
Biomech Model Mechanobiol. 2024 Apr 25. doi: 10.1007/s10237-024-01843-5. Online ahead of print.ABSTRACTRecent mouse brain injury experiments examine diffuse axonal injury resulting from accelerative head rotations. Evaluating brain deformation during these events would provide valuable information on tissue level thresholds for brain injury, but there are many challenges to imaging the brain's mechanical response during dynamic loading events, such as a blunt head impact. To address this shortcoming, we present an experimentally validated computational biomechanics model of the mouse brain that predicts tissue deformation,...
Source: Biomechanics and Modeling in Mechanobiology - April 25, 2024 Category: Biomedical Science Authors: Connor Bradfield Liming Voo Anindya Bhaduri K T Ramesh Source Type: research

Fracture mechanics modeling of aortic dissection
Biomech Model Mechanobiol. 2024 Apr 24. doi: 10.1007/s10237-024-01845-3. Online ahead of print.ABSTRACTAortic dissection, a critical cardiovascular condition with life-threatening implications, is distinguished by the development of a tear and its propagation within the aortic wall. A thorough understanding of the initiation and progression of these tears, or cracks, is essential for accurate diagnosis and effective treatment. This paper undertakes a fracture mechanics approach to delve into the mechanics of tear propagation in aortic dissection. Our objective is to elucidate the impact of geometric and material parameters...
Source: Biomechanics and Modeling in Mechanobiology - April 24, 2024 Category: Biomedical Science Authors: Ram Hemanth Yeerella Shengqiang Cai Source Type: research

Determining a musculoskeletal system's pre-stretched state using continuum-mechanical forward modelling and joint range optimization
Biomech Model Mechanobiol. 2024 Apr 15. doi: 10.1007/s10237-024-01821-x. Online ahead of print.ABSTRACTThe subject-specific range of motion (RoM) of a musculoskeletal joint system is balanced by pre-tension levels of individual muscles, which affects their contraction capability. Such an inherent pre-tension or pre-stretch of muscles is not measureable with in vivo experiments. Using a 3D continuum mechanical forward simulation approach for motion analysis of the musculoskeletal system of the forearm with 3 flexor and 2 extensor muscles, we developed an optimization process to determine the muscle fibre pre-stretches for a...
Source: Biomechanics and Modeling in Mechanobiology - April 15, 2024 Category: Biomedical Science Authors: Okan Avci Oliver R öhrle Source Type: research

The mechanical effects of chemical stimuli on neurospheres
Biomech Model Mechanobiol. 2024 Apr 13. doi: 10.1007/s10237-024-01841-7. Online ahead of print.ABSTRACTThe formulation of more accurate models to describe tissue mechanics necessitates the availability of tools and instruments that can precisely measure the mechanical response of tissues to physical loads and other stimuli. In this regard, neuroscience has trailed other life sciences owing to the unavailability of representative live tissue models and deficiency of experimentation tools. We previously addressed both challenges by employing a novel instrument called the cantilevered-capillary force apparatus (CCFA) to eluci...
Source: Biomechanics and Modeling in Mechanobiology - April 13, 2024 Category: Biomedical Science Authors: Yun-Han Huang Roza Vaez Ghaemi James Cheon Vikramaditya G Yadav John M Frostad Source Type: research