Electroconductive cardiac patch based on bioactive PEDOT:PSS hydrogels
This study introduces a synthetic patch with a bioactive surface designed to swiftly restore functionality to the damaged myocardium. The patch combines a composite, soft, and conductive hydrogel-based on (3,4-ethylenedioxythiophene):polystyrene-sulfonate (PEDOT:PSS) and polyvinyl alcohol (PVA). This cardiac patch exhibits a reasonably high electrical conductivity (40 S/cm) and a stretchability up to 50% of its original length. Our findings reveal its resilience to 10% cyclic stretching at 1 Hz with no loss of conductivity over time. To mediate a strong cell-scaffold adhesion, we biofunctionalize the hydrogel with a N-cadh...
Source: Biomed Res - May 1, 2024 Category: Research Authors: Erwan Sauvage Justin Matta Cat-Thy Dang Jiaxin Fan Graziele Cruzado Fabio Cicoira G éraldine Merle Source Type: research
Electroconductive cardiac patch based on bioactive PEDOT:PSS hydrogels
This study introduces a synthetic patch with a bioactive surface designed to swiftly restore functionality to the damaged myocardium. The patch combines a composite, soft, and conductive hydrogel-based on (3,4-ethylenedioxythiophene):polystyrene-sulfonate (PEDOT:PSS) and polyvinyl alcohol (PVA). This cardiac patch exhibits a reasonably high electrical conductivity (40 S/cm) and a stretchability up to 50% of its original length. Our findings reveal its resilience to 10% cyclic stretching at 1 Hz with no loss of conductivity over time. To mediate a strong cell-scaffold adhesion, we biofunctionalize the hydrogel with a N-cadh...
Source: Biomed Res - May 1, 2024 Category: Research Authors: Erwan Sauvage Justin Matta Cat-Thy Dang Jiaxin Fan Graziele Cruzado Fabio Cicoira G éraldine Merle Source Type: research
Assessing Concordance of Results: A Comparative Study of the Manual and Automated Urinalysis Methods
CONCLUSION: The automated and manual methods showed similar performances and good correlation, especially for physical and chemical examination. However, manual microscopy remains necessary to classify urine sediments, particularly for bacteria and yeast-like cells. Future research with larger samples could help validate automated urinalysis for wider clinical use and identify areas requiring improved automated detection capabilities.PMID:38682117 | PMC:PMC11055648 | DOI:10.1155/2024/6963423 (Source: Biomed Res)
Source: Biomed Res - April 29, 2024 Category: Research Authors: Nicholas Kwame Afriyie Gyamfi George Nkrumah Osei Ruth C Brenyah Lawrence Duah Agyemang Paulina Ampomah Kwame Osei Darkwah Emmanuel Toboh Richard K D Ephraim Source Type: research
A Phase II study of ERK inhibition by ulixertinib (BVD-523) in Metastatic Uveal Melanoma
CONCLUSIONS: ERK inhibition with ulixertinib (BVD-523) did not demonstrate activity in patients with metastatic uveal melanoma. The toxicities observed were consistent with what would be expected with MAPK pathway inhibition.PMID:38683104 | DOI:10.1158/2767-9764.CRC-24-0036 (Source: Biomed Res)
Source: Biomed Res - April 29, 2024 Category: Research Authors: Elizabeth I Buchbinder Justine V Cohen Giuseppe Tarantino Christine G Lian David Liu Rizwan Haq F Stephen Hodi Donald P Lawrence Anita Giobbie-Hurder Deborah Knoerzer Ryan J Sullivan Source Type: research
Assessing Concordance of Results: A Comparative Study of the Manual and Automated Urinalysis Methods
CONCLUSION: The automated and manual methods showed similar performances and good correlation, especially for physical and chemical examination. However, manual microscopy remains necessary to classify urine sediments, particularly for bacteria and yeast-like cells. Future research with larger samples could help validate automated urinalysis for wider clinical use and identify areas requiring improved automated detection capabilities.PMID:38682117 | PMC:PMC11055648 | DOI:10.1155/2024/6963423 (Source: Biomed Res)
Source: Biomed Res - April 29, 2024 Category: Research Authors: Nicholas Kwame Afriyie Gyamfi George Nkrumah Osei Ruth C Brenyah Lawrence Duah Agyemang Paulina Ampomah Kwame Osei Darkwah Emmanuel Toboh Richard K D Ephraim Source Type: research
A Phase II study of ERK inhibition by ulixertinib (BVD-523) in Metastatic Uveal Melanoma
CONCLUSIONS: ERK inhibition with ulixertinib (BVD-523) did not demonstrate activity in patients with metastatic uveal melanoma. The toxicities observed were consistent with what would be expected with MAPK pathway inhibition.PMID:38683104 | DOI:10.1158/2767-9764.CRC-24-0036 (Source: Biomed Res)
Source: Biomed Res - April 29, 2024 Category: Research Authors: Elizabeth I Buchbinder Justine V Cohen Giuseppe Tarantino Christine G Lian David Liu Rizwan Haq F Stephen Hodi Donald P Lawrence Anita Giobbie-Hurder Deborah Knoerzer Ryan J Sullivan Source Type: research
Bonding of ceramics to silver-coated titanium-A combined theoretical and experimental study
J Biomed Mater Res B Appl Biomater. 2024 May;112(5):e35407. doi: 10.1002/jbm.b.35407.ABSTRACTIt would be very beneficial to have a method for joining of ceramics to titanium reliably. Although several techniques have been developed and tested to prevent extensive interfacial chemical reactions in titanium-ceramic systems, the main problem of the inherent brittleness of interfaces was still unsolved. To overcome this problem also in dental applications, we decided to make use of an interlayer material that needs to meet the following requirements: First, it has to be biocompatible, second, it should not melt below the bondi...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Vesa Vuorinen Reijo Kouhia Mauno K önönen Jorma K Kivilahti Source Type: research
Biodegradable electrospun poly(L-lactide-co- ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering
In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L-lactide-co-ε-caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate-chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone-derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently en...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Joyce R de Souza Lais M Cardoso Priscila T A de Toledo Maedeh Rahimnejad Let ícia T Kito Gilmar P Thim Tiago M B Campos Alexandre L S Borges Marco C Bottino Source Type: research
The crystallization properties of antifreeze GelMA hydrogel and its application in cryopreservation of tissue-engineered skin constructs
J Biomed Mater Res B Appl Biomater. 2024 May;112(5):e35408. doi: 10.1002/jbm.b.35408.ABSTRACTGelatin methacrylate (GelMA) hydrogels are expected to be ideal skin tissue engineering dressings for a wide range of clinical treatments. Herein, we report the preparation of GelMA or antifreeze GelMA hydrogel sheets with different GelMA concentrations, crosslinking times, and cryoprotectant (CPA) concentrations. The crystallization properties of GelMA or antifreeze GelMA hydrogel sheets were studied by cryomicroscopy and differential scanning calorimetry (DSC). It was found that the growth of ice crystals was slower when GelMA hy...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Jia Tan Jiahui Li Xinli Zhou Source Type: research
Bonding of ceramics to silver-coated titanium-A combined theoretical and experimental study
J Biomed Mater Res B Appl Biomater. 2024 May;112(5):e35407. doi: 10.1002/jbm.b.35407.ABSTRACTIt would be very beneficial to have a method for joining of ceramics to titanium reliably. Although several techniques have been developed and tested to prevent extensive interfacial chemical reactions in titanium-ceramic systems, the main problem of the inherent brittleness of interfaces was still unsolved. To overcome this problem also in dental applications, we decided to make use of an interlayer material that needs to meet the following requirements: First, it has to be biocompatible, second, it should not melt below the bondi...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Vesa Vuorinen Reijo Kouhia Mauno K önönen Jorma K Kivilahti Source Type: research
The crystallization properties of antifreeze GelMA hydrogel and its application in cryopreservation of tissue-engineered skin constructs
J Biomed Mater Res B Appl Biomater. 2024 May;112(5):e35408. doi: 10.1002/jbm.b.35408.ABSTRACTGelatin methacrylate (GelMA) hydrogels are expected to be ideal skin tissue engineering dressings for a wide range of clinical treatments. Herein, we report the preparation of GelMA or antifreeze GelMA hydrogel sheets with different GelMA concentrations, crosslinking times, and cryoprotectant (CPA) concentrations. The crystallization properties of GelMA or antifreeze GelMA hydrogel sheets were studied by cryomicroscopy and differential scanning calorimetry (DSC). It was found that the growth of ice crystals was slower when GelMA hy...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Jia Tan Jiahui Li Xinli Zhou Source Type: research
Biodegradable electrospun poly(L-lactide-co- ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering
In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L-lactide-co-ε-caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate-chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone-derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently en...
Source: Biomed Res - April 27, 2024 Category: Research Authors: Joyce R de Souza Lais M Cardoso Priscila T A de Toledo Maedeh Rahimnejad Let ícia T Kito Gilmar P Thim Tiago M B Campos Alexandre L S Borges Marco C Bottino Source Type: research
Epidemiology of Celiac Disease in Western Iran during 2019-2021
This study demonstrated a higher prevalence of celiac disease in Kermanshah compared to global statistics. Given the association of celiac disease with other conditions such as diabetes, irritable bowel syndrome, growth retardation, and iron-deficiency anemia, healthcare providers should consider screening patients for celiac disease. Furthermore, community-based education is crucial in raising awareness about the significance of adhering to a proper diet and reducing wheat consumption.PMID:38665986 | PMC:PMC11045285 | DOI:10.1155/2024/1112812 (Source: Biomed Res)
Source: Biomed Res - April 26, 2024 Category: Research Authors: Maryam Janatolmakan Mehdi Zobeiri Shahab Rezaeian Shima Rostami Mehnosh Akbari Alireza Khatony Source Type: research
Epidemiology of Celiac Disease in Western Iran during 2019-2021
This study demonstrated a higher prevalence of celiac disease in Kermanshah compared to global statistics. Given the association of celiac disease with other conditions such as diabetes, irritable bowel syndrome, growth retardation, and iron-deficiency anemia, healthcare providers should consider screening patients for celiac disease. Furthermore, community-based education is crucial in raising awareness about the significance of adhering to a proper diet and reducing wheat consumption.PMID:38665986 | PMC:PMC11045285 | DOI:10.1155/2024/1112812 (Source: Biomed Res)
Source: Biomed Res - April 26, 2024 Category: Research Authors: Maryam Janatolmakan Mehdi Zobeiri Shahab Rezaeian Shima Rostami Mehnosh Akbari Alireza Khatony Source Type: research
The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women
CONCLUSION: The study highlights the importance of HRG rs10770 in understanding RM, shedding light on its implications for reproductive health. Furthermore, it became evident that women carrying the homozygous C/C genotype exhibited increased susceptibility to the risk of RM.PMID:38659607 | PMC:PMC11042909 | DOI:10.1155/2024/2501086 (Source: Biomed Res)
Source: Biomed Res - April 25, 2024 Category: Research Authors: Mahbobeh Latifimehr Leila Nazari Ali Asghar Rastegari Zahra Zamani Pezhman Fard-Esfahani Source Type: research
