Global threat posed by metals and metalloids in the changing environment: a One Health approach to mechanisms of toxicity
Biometals. 2024 May 6. doi: 10.1007/s10534-024-00606-0. Online ahead of print.NO ABSTRACTPMID:38709440 | DOI:10.1007/s10534-024-00606-0 (Source: Biometals)
Source: Biometals - May 6, 2024 Category: Biochemistry Authors: Wing-Kee Lee Frank Th évenod Elmar J Prenner Source Type: research
Nanomedicine: Patuletin-conjugated with zinc oxide exhibit potent effects against Gram-negative and Gram-positive bacterial pathogens
This study suggests that Patuletin-loaded nano-formulation (PA-GA-ZnO) may be implicated in a multi-target mechanism that affects both Gram-positive and Gram-negative pathogen cell structures, however this needs to be ascertained in future work.PMID:38705945 | DOI:10.1007/s10534-024-00595-0 (Source: Biometals)
Source: Biometals - May 5, 2024 Category: Biochemistry Authors: Naveed Ahmed Khan Adeelah Alvi Saif Alqassim Noor Akbar Bushra Khatoon Muhammad Kawish Shaheen Faizi Muhammad Raza Shah Bader S Alawfi Ruqaiyyah Siddiqui Source Type: research
Insights on the endogenous labile iron pool binding properties
Biometals. 2024 May 1. doi: 10.1007/s10534-024-00591-4. Online ahead of print.ABSTRACTUnder normal physiological conditions, the endogenous Labile Iron Pool (LIP) constitutes a ubiquitous, dynamic, tightly regulated reservoir of cellular ferrous iron. Furthermore, LIP is loaded into new apo-iron proteins, a process akin to the activity of metallochaperones. Despite such importance on iron metabolism, the LIP identity and binding properties have remained elusive. We hypothesized that LIP binds to cell constituents (generically denoted C) and forms an iron complex termed CLIP. Combining this binding model with the establishe...
Source: Biometals - May 1, 2024 Category: Biochemistry Authors: Andr é Luís Condeles Gabriel Simonetti da Silva Maria Beatriz Braghetto Hernandes Jos é Carlos Toledo Junior Source Type: research
Insights on the endogenous labile iron pool binding properties
Biometals. 2024 May 1. doi: 10.1007/s10534-024-00591-4. Online ahead of print.ABSTRACTUnder normal physiological conditions, the endogenous Labile Iron Pool (LIP) constitutes a ubiquitous, dynamic, tightly regulated reservoir of cellular ferrous iron. Furthermore, LIP is loaded into new apo-iron proteins, a process akin to the activity of metallochaperones. Despite such importance on iron metabolism, the LIP identity and binding properties have remained elusive. We hypothesized that LIP binds to cell constituents (generically denoted C) and forms an iron complex termed CLIP. Combining this binding model with the establishe...
Source: Biometals - May 1, 2024 Category: Biochemistry Authors: Andr é Luís Condeles Gabriel Simonetti da Silva Maria Beatriz Braghetto Hernandes Jos é Carlos Toledo Junior Source Type: research
Insights on the endogenous labile iron pool binding properties
Biometals. 2024 May 1. doi: 10.1007/s10534-024-00591-4. Online ahead of print.ABSTRACTUnder normal physiological conditions, the endogenous Labile Iron Pool (LIP) constitutes a ubiquitous, dynamic, tightly regulated reservoir of cellular ferrous iron. Furthermore, LIP is loaded into new apo-iron proteins, a process akin to the activity of metallochaperones. Despite such importance on iron metabolism, the LIP identity and binding properties have remained elusive. We hypothesized that LIP binds to cell constituents (generically denoted C) and forms an iron complex termed CLIP. Combining this binding model with the establishe...
Source: Biometals - May 1, 2024 Category: Biochemistry Authors: Andr é Luís Condeles Gabriel Simonetti da Silva Maria Beatriz Braghetto Hernandes Jos é Carlos Toledo Junior Source Type: research
Insights on the endogenous labile iron pool binding properties
Biometals. 2024 May 1. doi: 10.1007/s10534-024-00591-4. Online ahead of print.ABSTRACTUnder normal physiological conditions, the endogenous Labile Iron Pool (LIP) constitutes a ubiquitous, dynamic, tightly regulated reservoir of cellular ferrous iron. Furthermore, LIP is loaded into new apo-iron proteins, a process akin to the activity of metallochaperones. Despite such importance on iron metabolism, the LIP identity and binding properties have remained elusive. We hypothesized that LIP binds to cell constituents (generically denoted C) and forms an iron complex termed CLIP. Combining this binding model with the establishe...
Source: Biometals - May 1, 2024 Category: Biochemistry Authors: Andr é Luís Condeles Gabriel Simonetti da Silva Maria Beatriz Braghetto Hernandes Jos é Carlos Toledo Junior Source Type: research
Insights on the endogenous labile iron pool binding properties
Biometals. 2024 May 1. doi: 10.1007/s10534-024-00591-4. Online ahead of print.ABSTRACTUnder normal physiological conditions, the endogenous Labile Iron Pool (LIP) constitutes a ubiquitous, dynamic, tightly regulated reservoir of cellular ferrous iron. Furthermore, LIP is loaded into new apo-iron proteins, a process akin to the activity of metallochaperones. Despite such importance on iron metabolism, the LIP identity and binding properties have remained elusive. We hypothesized that LIP binds to cell constituents (generically denoted C) and forms an iron complex termed CLIP. Combining this binding model with the establishe...
Source: Biometals - May 1, 2024 Category: Biochemistry Authors: Andr é Luís Condeles Gabriel Simonetti da Silva Maria Beatriz Braghetto Hernandes Jos é Carlos Toledo Junior Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population
Conclusions. Among the explored metals, exposure to Cu and iodine impairs renal function. In contrast, Se may manifest as a beneficial metal. Interactions of Mo-Se and Mo-Iodine seem to alter the expression of NGAL; Mo-Cu for CLU; Mo-Cu, Mo-Se, and Mo-iodine for Cys-C and a-1MG; and Mo-Cu and Mo-iodine for KIM-1; were noticed. Our study could suggest that trace element interactions were associated with early kidney damage biomarkers.PMID:38642266 | DOI:10.1007/s10534-024-00603-3 (Source: Biometals)
Source: Biometals - April 20, 2024 Category: Biochemistry Authors: Manolo Ortega-Romero Elodia Rojas-Lima Juan Carlos Rubio-Guti érrez Octavio Gamaliel Aztatzi-Aguilar Juana Narv áez-Morales Mariela Esparza-Garc ía Ángel Barrera-Hernández Miguel Ángel Mejia Pablo Mendez-Hern ández Mara Medeiros Olivier Christophe Source Type: research
Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley
Biometals. 2024 Apr 14. doi: 10.1007/s10534-024-00597-y. Online ahead of print.ABSTRACTCadmium (Cd) is a widely distributed pollutant that adversely affects plants' metabolism and productivity. Phytohormones play a vital role in the acclimation of plants to metal stress. On the other hand, phytohormones trigger systemic resistances, including systemic acquired resistance (SAR) and induced systemic resistance (ISR), in plants in response to biotic interactions. The present study aimed to investigate the possible induction of SAR and ISR pathways in relation to the hormonal alteration of barley seedlings in response to Cd st...
Source: Biometals - April 13, 2024 Category: Biochemistry Authors: Fatemeh Alzahra Neyshabouri Ali Akbar Ghotbi-Ravandi Zeinab Shariatmadari Masoud Tohidfar Source Type: research
