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PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF- β and inhibiting Wnt signaling
Biosci Rep. 2024 Apr 30:BSR20231964. doi: 10.1042/BSR20231964. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta(PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble facto...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Tanawat Uthanaphun Sirikul Manochantr Chairat Tantrawatpan Duangrat Tantikanlayaporn Pakpoom Kheolamai Source Type: research

Does Acinetobacter calcoaceticus glucose dehydrogenase produce self-damaging H2O2?
We report the characterization of two sGDH mutants: the single mutant Y343F, and the double mutant D143E/Y343F. The mutants present enzyme selectivity and specificity of 1.2 (Y343F) and 5.7 (D143E/Y343F) times higher for glucose compared to that of the wild type. Crystallographic experiments, designed to characterise these mutants, surprisingly revealed that the prosthetic group PQQ (pyrroloquinoline quinone), essential for the enzymatic activity, is in a cleaved form for both wild-type and mutant structures. We provide evidence suggesting that the sGDH produces H2O2, the level of production depending on the mutation. In a...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Victoria Lublin Brice Kauffmann Sylvain Engilberge Fabien Durola S ébastien Gounel Sabrina Bichon Clo ée Jean Nicolas Mano Marie-France Giraud L éonard Chavas Aur élien Thureau Andrew Thompson Claire Stines-Chaumeil Source Type: research

Expression of Concern: Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to upregulate ZEB1 and MDM2
Biosci Rep. 2024 May 29;44(5):BSR-2020-0825_EOC. doi: 10.1042/BSR-2020-0825_EOC.NO ABSTRACTPMID:38682476 | DOI:10.1042/BSR-2020-0825_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 29, 2024 Category: Biomedical Science Source Type: research

Retraction: MiR-34b inhibits the proliferation and promotes apoptosis in colon cancer cells by targeting Wnt/ β-catenin signaling pathway
Biosci Rep. 2024 May 29;44(5):BSR-2019-1799_RET. doi: 10.1042/BSR-2019-1799_RET.NO ABSTRACTPMID:38682477 | DOI:10.1042/BSR-2019-1799_RET (Source: Bioscience Reports)
Source: Bioscience Reports - April 29, 2024 Category: Biomedical Science Source Type: research

Retraction: Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as a miR-340 sponge
Biosci Rep. 2024 May 29;44(5):BSR-2018-0941_RET. doi: 10.1042/BSR-2018-0941_RET.NO ABSTRACTPMID:38682478 | DOI:10.1042/BSR-2018-0941_RET (Source: Bioscience Reports)
Source: Bioscience Reports - April 29, 2024 Category: Biomedical Science Source Type: research

Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases
Conclusions: TMAO levels are increased with expanded CVD risk. Across different types of vascular damage, TMAO is associated with atherosclerotic changes.PMID:38669041 | DOI:10.1042/BSR20232090 (Source: Bioscience Reports)
Source: Bioscience Reports - April 26, 2024 Category: Biomedical Science Authors: Natalia Spasova Desislava Somleva Bozhidar Krastev Radostina Ilieva Angelina Borizanova Dobrin Svinarov Elena Kinova Assen Goudev Source Type: research

Protein disulfide isomerase uses thrombin-antithrombin complex as a template to bind its target protein and alter the blood coagulation rates
Biosci Rep. 2024 Apr 25:BSR20231540. doi: 10.1042/BSR20231540. Online ahead of print.ABSTRACTDuring inflammation and situations of cellular stress Protein Disulfide Isomerase (PDI) is released in the blood plasma from the platelet and endothelial cells to influence thrombosis. The addition of exogenous PDI makes the environment pro-thrombotic by inducing disulfide bond formation in specific plasma protein targets like vitronectin, factor V, and factor XI. However, the mechanistic details of PDI interaction with its target remain largely unknown. A decrease in the coagulation time was detected in activated partial thrombopl...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Abdul Burhan Khan Urfi Siddiqui Sana Fatima Ahmed Abdur Rehman Mohamad Aman Jairajpuri Source Type: research

A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride
This study aimed to evaluate the joint action of a high-fat diet and CCl4 in developing a short-term non-alcoholic steatohepatitis model. C57BL6/J mice were divided into two groups: standard diet-fed (SD), the high-fat diet-fed (HFD) and HFD + fructose-fed and carbon tetrachloride (HFD+CCl4). Animals fed with HFD+CCl4 presented increased lipid deposition compared with both SD and HFD mice. Plasma cholesterol was increased in animals from the HFD+CCl4 group compared to the SD and HFD groups, without significant differences between the SD and HFD groups. Plasma triglycerides showed no significant difference between the group...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Layanne C C Araujo Carolina C B Dias Felipe G Sucupira Leandra N Z Ramalho Joao Paulo Camporez Source Type: research