Efficacy and effect on lipid profiles of Ainuovirine-based regimen versus Efavirenz-based regimen in treatment-na ïve people with HIV-1 at week 24: A real-world, retrospective, multi-center cohort study
This study aimed to compare the efficacy and effect on lipid profiles of Ainuovirine (ANV)- and efavirenz (EFV) -based regimens in treatment-naïve people living with HIV-1 (PLWH) at week 24. The proportion of PLWH achieving HIV-1 RNA < the limit of quantification in the ANV group was significantly higher than that in the EFV group (89.18% vs. 76.04%, P = 0.002). The mean change of log10 HIV-1 RNA from baseline was greater (-4.34 vs. -4.18, P < 0.001), the median change from baseline in CD4+ T cell count increased more (106.00 cells/μL vs. 92.00 cells/μL, P = 0.007) in the ANV group, while the CD4+/CD8+ ratio was s...
Source: BioScience Trends - April 29, 2024 Category: Biomedical Science Authors: Hai Long Quanying He Yanmei Bi Yingchun Ke Xiaoxin Xie Xiuhong Zhao Si Tan Yanhe Luo Zhong Chen Xiaoli Yu Linghua Li Source Type: research
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01100. Online ahead of print.ABSTRACTAs the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Kenji Karako Wei Tang Peipei Song Ying Xia Source Type: research
Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
Biosci Trends. 2024 Apr 24. doi: 10.5582/bst.2024.01062. Online ahead of print.ABSTRACTAntiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world s...
Source: BioScience Trends - April 24, 2024 Category: Biomedical Science Authors: Fang Zhao Hongzhou Lu Source Type: research
Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia
In conclusion, the accumulation of lipid droplets and abnormal lipid metabolism may be critical mechanisms in the progression of AD in microglia carrying the APOE4 genotype.PMID:38631884 | DOI:10.5582/bst.2024.01092 (Source: BioScience Trends)
Source: BioScience Trends - April 17, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Ying Xia Source Type: research
