VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma
BMB Rep. 2024 Apr 23:6090. Online ahead of print.ABSTRACTThe aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Jungwhoi Lee Woogwang Sim Jungsul Lee Jae-Hoon Kim Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
Gut microbiota-generated metabolites: missing puzzles to hosts' health, diseases, and aging
BMB Rep. 2024 Apr 17:6194. Online ahead of print.ABSTRACTThe gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate imp...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Yan Zhang Shibo Wei Hang Zhang Yunju Jo Jong-Sun Kang Ki-Tae Ha Jongkil Joo Hyun Joo Lee Dongryeol Ryu Source Type: research
