Analyzing the expression and clinical significance of CENPE in gastric cancer
Gastric cancer (GC) is a prevalent type of malignant gastrointestinal tumor. Many studies have shown that CENPE acts as an oncogene in some cancers. However, its expression level and clinical value in GC are n... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - May 3, 2024 Category: Genetics & Stem Cells Authors: Jing Wang, Xiaofei Li, Xihui Qiang, Xueqing Yin and Lianyi Guo Tags: Research Source Type: research
Identification of sepsis-associated mitochondrial genes through RNA and single-cell sequencing approaches
Sepsis ranks among the most formidable clinical challenges, characterized by exorbitant treatment costs and substantial demands on healthcare resources. Mitochondrial dysfunction emerges as a pivotal risk fact... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - May 3, 2024 Category: Genetics & Stem Cells Authors: Shilin Li, Xiang Li, Sishi Jiang, Chenglin Wang and Yingchun Hu Tags: Research Source Type: research
Identification of prognostic stemness-related genes in kidney renal papillary cell carcinoma
Kidney renal papillary cell carcinoma (KIRP) is the second most prevalent malignant cancer originating from the renal epithelium. Nowadays, cancer stem cells and stemness-related genes (SRGs) are revealed to p... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - May 3, 2024 Category: Genetics & Stem Cells Authors: Yifan Liu, Yuntao Yao, Yu Zhang, Chengdang Xu, Tianyue Yang, Mingyu Qu, Bingnan Lu, Xu Song, Xiuwu Pan, Wang Zhou and Xingang Cui Tags: Research Source Type: research
No genetic causal association between periodontitis and ankylosing spondylitis: a bidirectional two-sample mendelian randomization analysis
Observational studies that reveal an association between periodontitis (PD) and ankylosing spondylitis (AS) exist. However, observational research is prone to reverse causality and confounding factors, which m... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - May 2, 2024 Category: Genetics & Stem Cells Authors: Chong Han, Dongchao Wu, Feiyan Yu, Qianqian Wang, Yang Yang, Yi Li, Rao Qin, Yue Chen, Linkun Xu and Dongning He Tags: Research Source Type: research
Circulating-tumour DNA methylation of HAND1 gene: a promising biomarker in early detection of colorectal cancer
Colorectal cancer (CRC) is one of the significant global health concerns with an increase in cases. Regular screening tests are crucial for early detection as it is often asymptomatic in the initial stages. Li... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 30, 2024 Category: Genetics & Stem Cells Authors: Mehrdad Shavali, Arash Moradi, Mohammad Tahmaseb, Kamal Mohammadian and Shahla Mohammad Ganji Tags: Research Source Type: research
Bioinformatics analysis revealed the potential crosstalk genes and molecular mechanisms between intracranial aneurysms and periodontitis
The risk of intracranial aneurysms (IAs) development and rupture is significantly higher in patients with periodontitis (PD), suggesting an association between the two. However, the specific mechanisms of asso... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 29, 2024 Category: Genetics & Stem Cells Authors: Yao Chen, Jian-huang Huang, Yuan-bao Kang, Zheng-jian Yao and Jian-hua Song Tags: Research Source Type: research
Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus
The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 29, 2024 Category: Genetics & Stem Cells Authors: Asma A Elashi, Salman M Toor, Umm-Kulthum Ismail Umlai, Yasser A Al-Sarraj, Shahrad Taheri, Karsten Suhre, Abdul Badi Abou-Samra and Omar M E Albagha Tags: Research Source Type: research
Identification of Novel NSD1 variations in four Pediatric cases with sotos Syndrome
Sotos syndrome (SOTOS) is an uncommon genetic condition that manifests itself with the following distinctive features: prenatal overgrowth, facial abnormalities, and intellectual disability. This disorder is o... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 29, 2024 Category: Genetics & Stem Cells Authors: Zhuo Ren, Ling Yue, Hua-ying Hu, Xiao-lin Hou, Wen-qi Chen, Ya Tan, Zhe Dong and Jing Zhang Tags: Research Source Type: research
Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression
The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely underst... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 29, 2024 Category: Genetics & Stem Cells Authors: Rui Mao, Chenxin Xu, Quanzheng Zhang, Zheng Wang, Yanjun Liu, Yurui Peng and Ming Li Tags: Research Source Type: research
Investigation of the interaction between genetic risk score (GRS) and fatty acid quality indices on metabolic syndrome among overweight and obese women
Metabolic syndrome is one of the major public-health challenges, affecting one-quarter of the world population. Fatty acid quality indices are novel determinants of this disease and their interactions with gen... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 29, 2024 Category: Genetics & Stem Cells Authors: Niloufar Rasaei, Elnaz Daneshzad, Alireza Khadem, Fatemeh Gholami, Mahsa Samadi and Khadijeh Mirzaei Tags: Research Source Type: research
Poor statistical power in population-based association study of gene interaction
Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype. In the genetic... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 27, 2024 Category: Genetics & Stem Cells Authors: Jiarui Ma, Jian Li, Yuqi Chen, Zhen Yang and Yungang He Tags: Research Source Type: research
Genetic variability in stroke patients: CYP2C19 polymorphisms unraveled
To study the distribution characteristics of CYP2C19 polymorphisms in patients suffering from stroke in Han Chinese patients. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Peiyi Peng, Yingxiu Xiao, Xuehong Peng, Jianqiang Chen and Nuan Chen Tags: Research Source Type: research
Short reads-based characterization of pathotype diversity and drug resistance among Escherichia coli isolated from patients attending regional referral hospitals in Tanzania
Escherichia coli is known to cause about 2 million deaths annually of which diarrhea infection is leading and typically occurs in children under 5 years old. Although Africa is the most affected region there is l... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Livin E. Kanje, Happiness Kumburu, Davis Kuchaka, Mariana Shayo, Masoud A. Juma, Patrick Kimu, Melkiory Beti, Marco van Zwetselaar, Boaz Wadugu, Blandina T. Mmbaga, Sixbert Isdory Mkumbaye and Tolbert Sonda Tags: Research Source Type: research
Syndromic ciliopathy: a taiwanese single-center study
Syndromic ciliopathies are a group of congenital disorders characterized by broad clinical and genetic overlap, including obesity, visual problems, skeletal anomalies, mental retardation, and renal diseases. T... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Yu-Wen Pan, Tsung-Ying Ou, Yen-Yin Chou, Pao-Lin Kuo, Hui-Pin Hsiao, Pao-Chin Chiu, Ju-Li Lin, Fu-Sung Lo, Chung-Hsing Wang, Peng-Chieh Chen and Meng-Che Tsai Tags: Research Source Type: research
Comprehensive characterization of immunogenic cell death in acute myeloid leukemia revealing the association with prognosis and tumor immune microenvironment
This study aimed to explore the clinical significance of immunogenic cell death (ICD) in acute myeloid leukemia (AML) and its relationship with the tumor immune microenvironment characteristics. It also aimed ... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Yongyu Chen, Xue Qiu and Rongrong Liu Tags: Research Source Type: research
