Mini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial
There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel... (Source: BMC Medicine)
Source: BMC Medicine - April 25, 2024 Category: Internal Medicine Authors: Yu Wang, Qi-Fa Liu, De-Pei Wu, Zheng-Li Xu, Ting-Ting Han, Yu-Qian Sun, Fen Huang, Zhi-Ping Fan, Na Xu, Feng Chen, Ye Zhao, Yuan Kong, Xiao-Dong Mo, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu & hellip; Tags: Research article Source Type: research
Long-term assessment of the NHS hybrid closed-loop real-world study on glycaemic outcomes, time-in-range, and quality of life in children and young people with type 1 diabetes
This study aimed to... (Source: BMC Medicine)
Source: BMC Medicine - April 24, 2024 Category: Internal Medicine Authors: Sze May Ng, Neil P. Wright, Diana Yardley, Fiona Campbell, Tabitha Randell, Nicola Trevelyan, Atrayee Ghatak and Peter C. Hindmarsh Tags: Research article Source Type: research
Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer
Osimertinib has become standard care for epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) patients whereas drug resistance remains inevitable. Now we recognize that the inter... (Source: BMC Medicine)
Source: BMC Medicine - April 24, 2024 Category: Internal Medicine Authors: Ruoshuang Han, Haoyue Guo, Jinpeng Shi, Sha Zhao, Yijun Jia, Xiaozhen Liu, Yiwei Liu, Lei Cheng, Chao Zhao, Xuefei Li and Caicun Zhou Tags: Research article Source Type: research
A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial
The stalling global progress in malaria control highlights the need for novel tools for malaria elimination, including transmission-blocking vaccines. Transmission-blocking vaccines aim to induce human antibod... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: M. Alkema, M. J. Smit, C. Marin-Mogollon, K. Tott é, K. Teelen, G. J. van Gemert, M. van de Vegte-Bolmer, B. G. Mordmüller, J. M. Reimer, K. L. Lövgren-Bengtsson, R. W. Sauerwein, T. Bousema, J. Plieskatt, M. Theisen, M. M. Jore and M. B. B. McCall Tags: Research article Source Type: research
Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly patients with prior coronary stents implanted > 12 months undergoing non-cardiac surgery: a randomized, placebo-controlled trial
Little is known about the safety and efficacy of discontinuing antiplatelet therapy via LMWH bridging therapy in elderly patients with coronary stents implanted for> 12 months undergoing non-cardiac surgery. ... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: Bin Wang, Yanhui Su, Cong Ma, Lining Xu, Qunxia Mao, Wenjia Cheng, Qingming Lu, Ying Zhang, Rong Wang, Yan Lu, Jing He, Shihao Chen, Lei Chen, Tianzhi Li and Linggen Gao Tags: Research article Source Type: research
Efficacy and safety of tislelizumab plus lenvatinib as first-line treatment in patients with unresectable hepatocellular carcinoma: a multicenter, single-arm, phase 2 trial
This study evaluated the efficacy and safety ... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: Li Xu, Jinzhang Chen, Chang Liu, Xiaoling Song, Yanqiao Zhang, Haitao Zhao, Sheng Yan, Weidong Jia, Zheng Wu, Yabing Guo, Jiayin Yang, Wei Gong, Yue Ma, Xiaobo Yang, Zhenzhen Gao, Nu Zhang & hellip; Tags: Research article Source Type: research
Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study
The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns as... (Source: BMC Medicine)
Source: BMC Medicine - April 23, 2024 Category: Internal Medicine Authors: Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engstr öm, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson and Olle Melander Tags: Research article Source Type: research
Impact of COVID-19 pandemic on depression incidence and healthcare service use among patients with depression: an interrupted time-series analysis from a 9-year population-based study
Most studies on the impact of the COVID-19 pandemic on depression burden focused on the earlier pandemic phase specific to lockdowns, but the longer-term impact of the pandemic is less well-studied. In this po... (Source: BMC Medicine)
Source: BMC Medicine - April 22, 2024 Category: Internal Medicine Authors: Vivien Kin Yi Chan, Yi Chai, Sandra Sau Man Chan, Hao Luo, Mark Jit, Martin Knapp, David Makram Bishai, Michael Yuxuan Ni, Ian Chi Kei Wong and Xue Li Tags: Research article Source Type: research
Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma
Unresectable intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis despite treatment with standard combination chemotherapy. We aimed to evaluate the efficacy and safety of radiotherapy in combination wi... (Source: BMC Medicine)
Source: BMC Medicine - April 19, 2024 Category: Internal Medicine Authors: Meiyan Zhu, Meng Jin, Xiao Zhao, Shunli Shen, Yihan Chen, Han Xiao, Guangyan Wei, Qiang He, Bin Li and Zhenwei Peng Tags: Research article Source Type: research
Prevalence and differences in the co-administration of drugs known to interact: an analysis of three distinct and large populations
This study aims to examine the drug –drug interaction (DDI) phenomenon with a large-scale longitudina... (Source: BMC Medicine)
Source: BMC Medicine - April 19, 2024 Category: Internal Medicine Authors: Jon S ánchez-Valle, Rion Brattig Correia, Marta Camacho-Artacho, Rosalba Lepore, Mauro M. Mattos, Luis M. Rocha and Alfonso Valencia Tags: Research article Source Type: research
Variability in the prevalence of depression among adults with chronic pain: UK Biobank analysis through clinical prediction models
The prevalence of depression among people with chronic pain remains unclear due to the heterogeneity of study samples and definitions of depression. We aimed to identify sources of variation in the prevalence ... (Source: BMC Medicine)
Source: BMC Medicine - April 19, 2024 Category: Internal Medicine Authors: Lingxiao Chen, Claire E Ashton-James, Baoyi Shi, Maja R Radoj čić, David B Anderson, Yujie Chen, David B Preen, John L Hopper, Shuai Li, Minh Bui, Paula R Beckenkamp, Nigel K Arden, Paulo H Ferreira, Hengxing Zhou, Shiqing Feng and Manuela L Ferreira Tags: Research article Source Type: research
Undiagnosed type 2 diabetes is common – intensified screening of established risk groups is imperative in Sweden: the SDPP cohort
Undiagnosed type 2 diabetes (T2D) is a global problem. Current strategies for diagnosis in Sweden include screening individuals within primary healthcare who are of high risk, such as those with hypertension, ... (Source: BMC Medicine)
Source: BMC Medicine - April 19, 2024 Category: Internal Medicine Authors: Hrafnhildur Gudjonsdottir, Per Tynelius, Nouha Saleh Stattin, Diego Yacam án Méndez, Anton Lager and Boel Brynedal Tags: Research article Source Type: research
Characterising smoking and nicotine use behaviours among women of reproductive age: a 10-year population study in England
This study explored trends by socioeconomic position in patterns of smoking, use of non-combust... (Source: BMC Medicine)
Source: BMC Medicine - April 18, 2024 Category: Internal Medicine Authors: Sarah E. Jackson, Jamie Brown, Caitlin Notley, Lion Shahab and Sharon Cox Tags: Research article Source Type: research
Quantifying the impact of hospital catchment area definitions on hospital admissions forecasts: COVID-19 in England, September 2020 –April 2021
Defining healthcare facility catchment areas is a key step in predicting future healthcare demand in epidemic settings. Forecasts of hospitalisations can be informed by leading indicators measured at the commu... (Source: BMC Medicine)
Source: BMC Medicine - April 17, 2024 Category: Internal Medicine Authors: Sophie Meakin and Sebastian Funk Tags: Research article Source Type: research
Lipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy
The metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. However, the processes and mechanisms unde... (Source: BMC Medicine)
Source: BMC Medicine - April 17, 2024 Category: Internal Medicine Authors: Chengcan Yang, Dongzi Zhu, Chaofan Liu, Wenyue Wang, Yining He, Bing Wang and Meiyi Li Tags: Research article Source Type: research
