BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy
In this study, an MDD model was established in mice using lipopolysaccharide (LPS). Our research findings demonstrated that LPS exposure induced depressive-like behaviors and disrupted mitophagy by diminishing the mitochondrial levels of PINK1/Parkin in the brains of mice. Furthermore, LPS exposure evoked the activation of the NLRP3 inflammasome, accompanied by a notable elevation in the concentrations of pro-inflammatory factors (TNF-α, IL-1β, and IL-6). Additionally, neuronal apoptosis was stimulated through the JNK/p38 pathway. The administration of BGP-15 effectively nullified the impact of LPS, corresponding to the ...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Qian Liu Jun-Ning Zhao Zhi-Ting Fang Xin Wang Bing-Ge Zhang Ye He Rui-Juan Liu Jian Chen Gong-Ping Liu Source Type: research
The antidepressant effect of whole-body hyperthermia is associated with the classical interleukin-6 signaling pathway
The objective of the study was to determine whether activation of the classical anti-inflammatory interleukin-6 signaling pathways is associated with the antidepressant effects of whole-body hyperthermia. A 6-week, randomized, double-blind study compared whole-body hyperthermia with a sham condition in a university-based medical center. Medically healthy participants aged 18-65 years who met criteria for major depressive disorder, were free of psychotropic medication use, and had a baseline 17-item Hamilton Depression Rating Scale score ≥ 16 were randomized with 1-to-1 allocation in blocks of 6 to receive whole-body hype...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Mac Giollabhui Naoise A Lowry Christopher Nyer Maren L Foster Simmie T Liu Richard G Smith David P Cole Steven E Mason Ashley Mischoulon David L Raison Charles Source Type: research
Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00375-1. doi: 10.1016/j.bbi.2024.04.026. Online ahead of print.ABSTRACTThe co-occurrence and familial clustering of neurodevelopmental disorders and immune disorders suggest shared genetic risk factors. Based on genome-wide association summary statistics from five neurodevelopmental disorders and four immune disorders, we conducted genome-wide, local genetic correlation and polygenic overlap analysis. We further performed a cross-trait GWAS meta-analysis. Pleotropic loci shared between the two categories of diseases were mapped to candidate genes using multiple algorithms and ap...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Zhanjie Xiu Ling Sun Haiyan Cao Huiqi Qu Joseph T Glessner Zhiyong Ding Gang Zheng Nan Wang Qianghua Xia Jie Li Hakon Hakonarson Wei Liu Jin Li Source Type: research
Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research
Examining the associations between microglia genetic capacity, early life exposures and white matter development at the level of the individual
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00387-8. doi: 10.1016/j.bbi.2024.04.038. Online ahead of print.ABSTRACTThere are inter-individual differences in susceptibility to the influence of early life experiences for which the underlying neurobiological mechanisms are poorly understood. Microglia play a role in environmental surveillance and may influence individual susceptibility to environmental factors. As an index of neurodevelopment, we estimated individual slopes of mean white matter fractional anisotropy (WM-FA) across three time-points (age 4.5, 6.0, and 7.5 years) for 351 participants. Individual variation in m...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Shi Yu Chan Eamon Fitzgerald Zhen Ming Ngoh Janice Lee Jasmine Chuah Joanne Shu Ming Chia Marielle V Fortier Elizabeth Huiwen Tham Juan H Zhou Patricia P Silveira Michael J Meaney Ai Peng Tan Source Type: research
BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy
In this study, an MDD model was established in mice using lipopolysaccharide (LPS). Our research findings demonstrated that LPS exposure induced depressive-like behaviors and disrupted mitophagy by diminishing the mitochondrial levels of PINK1/Parkin in the brains of mice. Furthermore, LPS exposure evoked the activation of the NLRP3 inflammasome, accompanied by a notable elevation in the concentrations of pro-inflammatory factors (TNF-α, IL-1β, and IL-6). Additionally, neuronal apoptosis was stimulated through the JNK/p38 pathway. The administration of BGP-15 effectively nullified the impact of LPS, corresponding to the ...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Qian Liu Jun-Ning Zhao Zhi-Ting Fang Xin Wang Bing-Ge Zhang Ye He Rui-Juan Liu Jian Chen Gong-Ping Liu Source Type: research
The antidepressant effect of whole-body hyperthermia is associated with the classical interleukin-6 signaling pathway
The objective of the study was to determine whether activation of the classical anti-inflammatory interleukin-6 signaling pathways is associated with the antidepressant effects of whole-body hyperthermia. A 6-week, randomized, double-blind study compared whole-body hyperthermia with a sham condition in a university-based medical center. Medically healthy participants aged 18-65 years who met criteria for major depressive disorder, were free of psychotropic medication use, and had a baseline 17-item Hamilton Depression Rating Scale score ≥ 16 were randomized with 1-to-1 allocation in blocks of 6 to receive whole-body hype...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Mac Giollabhui Naoise A Lowry Christopher Nyer Maren L Foster Simmie T Liu Richard G Smith David P Cole Steven E Mason Ashley Mischoulon David L Raison Charles Source Type: research
Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00375-1. doi: 10.1016/j.bbi.2024.04.026. Online ahead of print.ABSTRACTThe co-occurrence and familial clustering of neurodevelopmental disorders and immune disorders suggest shared genetic risk factors. Based on genome-wide association summary statistics from five neurodevelopmental disorders and four immune disorders, we conducted genome-wide, local genetic correlation and polygenic overlap analysis. We further performed a cross-trait GWAS meta-analysis. Pleotropic loci shared between the two categories of diseases were mapped to candidate genes using multiple algorithms and ap...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Zhanjie Xiu Ling Sun Haiyan Cao Huiqi Qu Joseph T Glessner Zhiyong Ding Gang Zheng Nan Wang Qianghua Xia Jie Li Hakon Hakonarson Wei Liu Jin Li Source Type: research
Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research
Examining the associations between microglia genetic capacity, early life exposures and white matter development at the level of the individual
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00387-8. doi: 10.1016/j.bbi.2024.04.038. Online ahead of print.ABSTRACTThere are inter-individual differences in susceptibility to the influence of early life experiences for which the underlying neurobiological mechanisms are poorly understood. Microglia play a role in environmental surveillance and may influence individual susceptibility to environmental factors. As an index of neurodevelopment, we estimated individual slopes of mean white matter fractional anisotropy (WM-FA) across three time-points (age 4.5, 6.0, and 7.5 years) for 351 participants. Individual variation in m...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Shi Yu Chan Eamon Fitzgerald Zhen Ming Ngoh Janice Lee Jasmine Chuah Joanne Shu Ming Chia Marielle V Fortier Elizabeth Huiwen Tham Juan H Zhou Patricia P Silveira Michael J Meaney Ai Peng Tan Source Type: research
BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy
In this study, an MDD model was established in mice using lipopolysaccharide (LPS). Our research findings demonstrated that LPS exposure induced depressive-like behaviors and disrupted mitophagy by diminishing the mitochondrial levels of PINK1/Parkin in the brains of mice. Furthermore, LPS exposure evoked the activation of the NLRP3 inflammasome, accompanied by a notable elevation in the concentrations of pro-inflammatory factors (TNF-α, IL-1β, and IL-6). Additionally, neuronal apoptosis was stimulated through the JNK/p38 pathway. The administration of BGP-15 effectively nullified the impact of LPS, corresponding to the ...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Qian Liu Jun-Ning Zhao Zhi-Ting Fang Xin Wang Bing-Ge Zhang Ye He Rui-Juan Liu Jian Chen Gong-Ping Liu Source Type: research
The antidepressant effect of whole-body hyperthermia is associated with the classical interleukin-6 signaling pathway
The objective of the study was to determine whether activation of the classical anti-inflammatory interleukin-6 signaling pathways is associated with the antidepressant effects of whole-body hyperthermia. A 6-week, randomized, double-blind study compared whole-body hyperthermia with a sham condition in a university-based medical center. Medically healthy participants aged 18-65 years who met criteria for major depressive disorder, were free of psychotropic medication use, and had a baseline 17-item Hamilton Depression Rating Scale score ≥ 16 were randomized with 1-to-1 allocation in blocks of 6 to receive whole-body hype...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Mac Giollabhui Naoise A Lowry Christopher Nyer Maren L Foster Simmie T Liu Richard G Smith David P Cole Steven E Mason Ashley Mischoulon David L Raison Charles Source Type: research
Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00375-1. doi: 10.1016/j.bbi.2024.04.026. Online ahead of print.ABSTRACTThe co-occurrence and familial clustering of neurodevelopmental disorders and immune disorders suggest shared genetic risk factors. Based on genome-wide association summary statistics from five neurodevelopmental disorders and four immune disorders, we conducted genome-wide, local genetic correlation and polygenic overlap analysis. We further performed a cross-trait GWAS meta-analysis. Pleotropic loci shared between the two categories of diseases were mapped to candidate genes using multiple algorithms and ap...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Zhanjie Xiu Ling Sun Haiyan Cao Huiqi Qu Joseph T Glessner Zhiyong Ding Gang Zheng Nan Wang Qianghua Xia Jie Li Hakon Hakonarson Wei Liu Jin Li Source Type: research
Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research
Examining the associations between microglia genetic capacity, early life exposures and white matter development at the level of the individual
Brain Behav Immun. 2024 Apr 25:S0889-1591(24)00387-8. doi: 10.1016/j.bbi.2024.04.038. Online ahead of print.ABSTRACTThere are inter-individual differences in susceptibility to the influence of early life experiences for which the underlying neurobiological mechanisms are poorly understood. Microglia play a role in environmental surveillance and may influence individual susceptibility to environmental factors. As an index of neurodevelopment, we estimated individual slopes of mean white matter fractional anisotropy (WM-FA) across three time-points (age 4.5, 6.0, and 7.5 years) for 351 participants. Individual variation in m...
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Shi Yu Chan Eamon Fitzgerald Zhen Ming Ngoh Janice Lee Jasmine Chuah Joanne Shu Ming Chia Marielle V Fortier Elizabeth Huiwen Tham Juan H Zhou Patricia P Silveira Michael J Meaney Ai Peng Tan Source Type: research
