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Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression
Brain Res Bull. 2024 Apr 28:110970. doi: 10.1016/j.brainresbull.2024.110970. Online ahead of print.ABSTRACTParkinson's disease (PD) is a severe neurodegenerative disease associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although its pathogenesis remains unclear, microglia-mediated neuroinflammation significantly contributes to the development of PD. Here we showed that the sine oculis homeobox (SIX) homologue family transcription factors SIX2 exerted significant effects on neuroinflammation. The SIX2 protein, which is silenced during development, was reactivated in lipopolysaccharide (LPS)...
Source: Brain Research Bulletin - April 30, 2024 Category: Neurology Authors: Xia-Yin Cao Yi Liu Jia-Shuo Kan Xin-Xing Huang Piniel Alphayo Kambey Can-Tang Zhang Jin Gao Source Type: research

Altered Cortical Thickness and Structural Covariance Networks in Chronic Low Back Pain
CONCLUSIONS: From the regional cortical thickness to the complex brain network level, our study demonstrated changes in the cortical thickness and topological properties of the SCNs in patients with CLBP, thus aiding in a better understanding of the pathophysiological mechanisms of CLBP.PMID:38679110 | DOI:10.1016/j.brainresbull.2024.110968 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 28, 2024 Category: Neurology Authors: Si-Yu Gu Feng-Chao Shi Shu Wang Cheng-Yu Wang Xin-Xin Yao Yi-Fan Sun Chuan-Xu Luo Wan-Ting Liu Jian-Bin Hu Fei Chen Ping-Lei Pan Wen-Hui Li Source Type: research

Retraction Notice to "Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in hippocampus of rats: Molecular, biochemical and histological evidences" [Brain. Res. Bull. 132 (2017) 82-98]
Brain Res Bull. 2024 Apr 27:110956. doi: 10.1016/j.brainresbull.2024.110956. Online ahead of print.NO ABSTRACTPMID:38679545 | DOI:10.1016/j.brainresbull.2024.110956 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 28, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Fatemeh Babalouei Mohammad Abdollahi Mansour Heidari Zahra Madjd Source Type: research

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research Bulletin - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research

Reading instruction causes changes in category-selective visual cortex
Brain Res Bull. 2024 Apr 25:110958. doi: 10.1016/j.brainresbull.2024.110958. Online ahead of print.ABSTRACTEducation sculpts specialized neural circuits for skills like reading that are critical to success in modern society but were not anticipated by the selective pressures of evolution. Does the emergence of brain regions that selectively process novel visual stimuli like words occur at the expense of cortical representations of other stimuli like faces and objects? "Neuronal Recycling" predicts that learning to read should enhance the response to words in ventral occipitotemporal cortex (VOTC) and decrease the response ...
Source: Brain Research Bulletin - April 27, 2024 Category: Neurology Authors: Jason D Yeatman Daniel R McCloy Sendy Caffarra Maggie D Clarke Suzanne Ender Liesbeth Gijbels Sung Jun Joo Emily C Kubota Patricia K Kuhl Eric Larson Gabrielle O'Brien Erica R Peterson Megumi E Takada Samu Taulu Source Type: research

Euchromatin histone-lysine N-methyltransferase 2 regulates the expression of potassium-sodium-activated channel subfamily T member 1 in primary sensory neurons and contributes to remifentanil-induced pain sensitivity
This study investigates whether G9a regulates the potassium sodium-activated channel subfamily T member 1 (Slo2.2) in remifentanil-induced post-incisional hyperalgesia (RIH) in rodents. We performed remifentanil infusion (1μg·kg-1·min-1 for 60min) followed by plantar incision to induce RIH in rodents. Our results showed that RIH was accompanied by increased G9a and H3K9me2 production and decreased Slo2.2 expression 48h postoperatively. Deletion of G9a rescued Slo2.2 expression in DRG and reduced RIH intensity. Slo2.2 overexpression also reversed this hyperalgesia phenotype. G9a overexpression decreased Slo2.2-mediated l...
Source: Brain Research Bulletin - April 26, 2024 Category: Neurology Authors: Qiang Zhang Ran Ding Yuanjie Li Dan Qiao Jiamin Kang Linyue Zong Yun Li Yuan Yuan Yang Jiao Chunyan Wang Yonghao Yu Linlin Zhang Yize Li Source Type: research

Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment
CONCLUSION: EA ameliorates memory impairment in a rat model of ischemic stroke by reducing inflammation and ROS through the inhibition of P2X7R expression. In turn, this mechanism regulates Nrf2 and NLRP3 expression, suggesting EA is beneficial for ischemic stroke treatment using P2X7R as target.PMID:38670470 | DOI:10.1016/j.brainresbull.2024.110967 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 26, 2024 Category: Neurology Authors: Bingbing Lin Mengxue Wang Xiaocheng Chen Linsong Chai Jinglei Ni Jia Huang Source Type: research

Argon neuroprotection in ischemic stroke and its underlying mechanism
Brain Res Bull. 2024 Apr 24:110964. doi: 10.1016/j.brainresbull.2024.110964. Online ahead of print.ABSTRACTIschemic stroke (IS), primarily caused by cerebrovascular obstruction, results in severe neurological deficits and has emerged as a leading cause of death and disability worldwide. Recently, there has been increasing exploration of the neuroprotective properties of the inert gas argon. Argon has exhibited impressive neuroprotection in many in vivo and ex vivo experiments without signs of adverse effects, coupled with the advantages of being inexpensive and easily available. However, the efficient administration strate...
Source: Brain Research Bulletin - April 26, 2024 Category: Neurology Authors: Li Bao Yongxin Liu Qi Jia Sihao Chu Han Jiang Shuang He Source Type: research

Corrigendum to "Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats" [Brain Res. Bull. 156 (2020) 33-42]
Brain Res Bull. 2024 Apr 24:110963. doi: 10.1016/j.brainresbull.2024.110963. Online ahead of print.NO ABSTRACTPMID:38664112 | DOI:10.1016/j.brainresbull.2024.110963 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 25, 2024 Category: Neurology Authors: Xiao Cheng Ying-Lin Yang Wei-Han Li Man Liu Yue-Hua Wang Guan-Hua Du Source Type: research