Probiotics, prebiotics, and synbiotics in childhood diarrhea
Braz J Med Biol Res. 2024 Apr 19;57:e13205. doi: 10.1590/1414-431X2024e13205. eCollection 2024.ABSTRACTAcute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and ...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: E M S Martins L C Nascimento da Silva M S Carmo Source Type: research
Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial
In conclusion, an acute session of WBV influenced sTNFr2 levels, with sarcopenic individuals showing a greater effect. This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.PMID:38656072 | PMC:PMC11027183 | DOI:10.1590/1414-431X2024e13282 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: H C Almeida V K S Lage R Taiar J M Santos F A de Paula A Rapin D C S á-Caputo M Bernardo-Filho A C R Lacerda V A Mendon ça Source Type: research
Induced acute hyperglycemia modifies the barrier function of the intestinal epithelium by tissue inflammation and tight junction disruption resulting in hydroelectrolytic secretion in an animal model
This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0.5 mL of streptozotocin (70 mg/kg). Glycemic and clinical parameters were evaluated every 7 days, and intestinal parameters were evaluated on the 14th day. The MetS-D animals showed a clinical pattern of hyperglycemia, with increases in the area of villi and crypts, lactulose:mannitol ratio, myeloperoxidase (MPO) activity, and intestinal tissue concentrations of malondialdeh...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: F J W S Siqueira F A P Rodrigues S A Ribeiro H N Veras F C S Ferreira R C L Siqueira A A Dos Santos A Havt A A M Lima Source Type: research
Integrative analyses of genetic characteristics associated with skeletal endothelial cells
In this study, we conducted a systematic analysis of differentially expressed genes (DEGs) and the associated pathways in juvenile and mature femoral ECs, utilizing data sourced from the Gene Expression Omnibus (GEO) repositories (GSE148804) and employing bioinformatics tools. Through this approach, we successfully discerned six pivotal genes, namely Adamts1, Adamts2, Adamts4, Adamts14, Col5a1, and Col5a2. Subsequently, we constructed a miRNA-mRNA network based on miRNAs displaying differential expression between CD31hiEMCNhi and CD31lowEMCNlow ECs, utilizing online repositories for prediction. The expression of miR-466i-3...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: Zhanhui Wang Bowen Hu Xiaoming Chen Zheng Zhang Lu Liu Nan Li Chun Liang Source Type: research
Development and validation of a clinical prediction model for prognostic factors in patients with primary pontine hemorrhage
Braz J Med Biol Res. 2024 Apr 19;57:e13359. doi: 10.1590/1414-431X2024e13359. eCollection 2024.ABSTRACTWe aimed to develop a prognostic model for primary pontine hemorrhage (PPH) patients and validate the predictive value of the model for a good prognosis at 90 days. A total of 254 PPH patients were included for screening of the independent predictors of prognosis, and data were analyzed by univariate and multivariable logistic regression tests. The cases were then divided into training cohort (n=219) and validation cohort (n=35) based on the two centers. A nomogram was developed using independent predictors from the train...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: Anquan Hu Heyan Qin Shina Wu Xiaolin Zhao Yumeng Li Feng Chen Tao Liu Source Type: research
Could nanotechnology improve exercise performance? Evidence from animal studies
In conclusion, nutritional nanocompounds are a promising approach to improving exercise performance. As the studies using nutritional nanocompounds were all conducted in animals, further studies in humans are necessary to better understand the application of nutritional nanocompounds in sport and exercise science.PMID:38656076 | PMC:PMC11027182 | DOI:10.1590/1414-431X2024e13360 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: M R Lima B J Moreira R Bertuzzi A E Lima-Silva Source Type: research
Probiotics, prebiotics, and synbiotics in childhood diarrhea
Braz J Med Biol Res. 2024 Apr 19;57:e13205. doi: 10.1590/1414-431X2024e13205. eCollection 2024.ABSTRACTAcute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and ...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: E M S Martins L C Nascimento da Silva M S Carmo Source Type: research
Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial
In conclusion, an acute session of WBV influenced sTNFr2 levels, with sarcopenic individuals showing a greater effect. This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.PMID:38656072 | PMC:PMC11027183 | DOI:10.1590/1414-431X2024e13282 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: H C Almeida V K S Lage R Taiar J M Santos F A de Paula A Rapin D C S á-Caputo M Bernardo-Filho A C R Lacerda V A Mendon ça Source Type: research
Induced acute hyperglycemia modifies the barrier function of the intestinal epithelium by tissue inflammation and tight junction disruption resulting in hydroelectrolytic secretion in an animal model
This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0.5 mL of streptozotocin (70 mg/kg). Glycemic and clinical parameters were evaluated every 7 days, and intestinal parameters were evaluated on the 14th day. The MetS-D animals showed a clinical pattern of hyperglycemia, with increases in the area of villi and crypts, lactulose:mannitol ratio, myeloperoxidase (MPO) activity, and intestinal tissue concentrations of malondialdeh...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: F J W S Siqueira F A P Rodrigues S A Ribeiro H N Veras F C S Ferreira R C L Siqueira A A Dos Santos A Havt A A M Lima Source Type: research
Integrative analyses of genetic characteristics associated with skeletal endothelial cells
In this study, we conducted a systematic analysis of differentially expressed genes (DEGs) and the associated pathways in juvenile and mature femoral ECs, utilizing data sourced from the Gene Expression Omnibus (GEO) repositories (GSE148804) and employing bioinformatics tools. Through this approach, we successfully discerned six pivotal genes, namely Adamts1, Adamts2, Adamts4, Adamts14, Col5a1, and Col5a2. Subsequently, we constructed a miRNA-mRNA network based on miRNAs displaying differential expression between CD31hiEMCNhi and CD31lowEMCNlow ECs, utilizing online repositories for prediction. The expression of miR-466i-3...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: Zhanhui Wang Bowen Hu Xiaoming Chen Zheng Zhang Lu Liu Nan Li Chun Liang Source Type: research
Development and validation of a clinical prediction model for prognostic factors in patients with primary pontine hemorrhage
Braz J Med Biol Res. 2024 Apr 19;57:e13359. doi: 10.1590/1414-431X2024e13359. eCollection 2024.ABSTRACTWe aimed to develop a prognostic model for primary pontine hemorrhage (PPH) patients and validate the predictive value of the model for a good prognosis at 90 days. A total of 254 PPH patients were included for screening of the independent predictors of prognosis, and data were analyzed by univariate and multivariable logistic regression tests. The cases were then divided into training cohort (n=219) and validation cohort (n=35) based on the two centers. A nomogram was developed using independent predictors from the train...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: Anquan Hu Heyan Qin Shina Wu Xiaolin Zhao Yumeng Li Feng Chen Tao Liu Source Type: research
Could nanotechnology improve exercise performance? Evidence from animal studies
In conclusion, nutritional nanocompounds are a promising approach to improving exercise performance. As the studies using nutritional nanocompounds were all conducted in animals, further studies in humans are necessary to better understand the application of nutritional nanocompounds in sport and exercise science.PMID:38656076 | PMC:PMC11027182 | DOI:10.1590/1414-431X2024e13360 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: M R Lima B J Moreira R Bertuzzi A E Lima-Silva Source Type: research
Probiotics, prebiotics, and synbiotics in childhood diarrhea
Braz J Med Biol Res. 2024 Apr 19;57:e13205. doi: 10.1590/1414-431X2024e13205. eCollection 2024.ABSTRACTAcute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and ...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: E M S Martins L C Nascimento da Silva M S Carmo Source Type: research
Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial
In conclusion, an acute session of WBV influenced sTNFr2 levels, with sarcopenic individuals showing a greater effect. This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.PMID:38656072 | PMC:PMC11027183 | DOI:10.1590/1414-431X2024e13282 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: H C Almeida V K S Lage R Taiar J M Santos F A de Paula A Rapin D C S á-Caputo M Bernardo-Filho A C R Lacerda V A Mendon ça Source Type: research
Induced acute hyperglycemia modifies the barrier function of the intestinal epithelium by tissue inflammation and tight junction disruption resulting in hydroelectrolytic secretion in an animal model
This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0.5 mL of streptozotocin (70 mg/kg). Glycemic and clinical parameters were evaluated every 7 days, and intestinal parameters were evaluated on the 14th day. The MetS-D animals showed a clinical pattern of hyperglycemia, with increases in the area of villi and crypts, lactulose:mannitol ratio, myeloperoxidase (MPO) activity, and intestinal tissue concentrations of malondialdeh...
Source: Braz J Med Biol Res - April 24, 2024 Category: Research Authors: F J W S Siqueira F A P Rodrigues S A Ribeiro H N Veras F C S Ferreira R C L Siqueira A A Dos Santos A Havt A A M Lima Source Type: research
