Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
The connection between Dr. Harold Griffith and Richard Gill: new insights into the history of curare use in anesthesia from previously unknown correspondence
Can J Anaesth. 2024 Apr 23. doi: 10.1007/s12630-024-02750-0. Online ahead of print.ABSTRACTDr. Harold R. Griffith and Richard C. Gill figure prominently in curare's storied history. In 1938, Gill returned from an Amazon expedition with over 11 kg of curare. After scientists at E. R. Squibb & Sons identified a plant source (Chondrodendron tomentosum) and isolated a stable extract of uniform potency (marketed as Intocostrin), Griffith administered it in the operating room in 1942, showing its advantages and safety. In this article, we report correspondence between Griffith and Gill, heretofore not appreciated, after find...
Source: Canadian Journal of Anaesthesia - April 23, 2024 Category: Anesthesiology Authors: Noha Elsherbini Steven B Backman Source Type: research
The connection between Dr. Harold Griffith and Richard Gill: new insights into the history of curare use in anesthesia from previously unknown correspondence
Can J Anaesth. 2024 Apr 23. doi: 10.1007/s12630-024-02750-0. Online ahead of print.ABSTRACTDr. Harold R. Griffith and Richard C. Gill figure prominently in curare's storied history. In 1938, Gill returned from an Amazon expedition with over 11 kg of curare. After scientists at E. R. Squibb & Sons identified a plant source (Chondrodendron tomentosum) and isolated a stable extract of uniform potency (marketed as Intocostrin), Griffith administered it in the operating room in 1942, showing its advantages and safety. In this article, we report correspondence between Griffith and Gill, heretofore not appreciated, after find...
Source: Canadian Journal of Anaesthesia - April 23, 2024 Category: Anesthesiology Authors: Noha Elsherbini Steven B Backman Source Type: research
The connection between Dr. Harold Griffith and Richard Gill: new insights into the history of curare use in anesthesia from previously unknown correspondence
Can J Anaesth. 2024 Apr 23. doi: 10.1007/s12630-024-02750-0. Online ahead of print.ABSTRACTDr. Harold R. Griffith and Richard C. Gill figure prominently in curare's storied history. In 1938, Gill returned from an Amazon expedition with over 11 kg of curare. After scientists at E. R. Squibb & Sons identified a plant source (Chondrodendron tomentosum) and isolated a stable extract of uniform potency (marketed as Intocostrin), Griffith administered it in the operating room in 1942, showing its advantages and safety. In this article, we report correspondence between Griffith and Gill, heretofore not appreciated, after find...
Source: Canadian Journal of Anaesthesia - April 23, 2024 Category: Anesthesiology Authors: Noha Elsherbini Steven B Backman Source Type: research
Competencies for proficiency in basic point-of-care ultrasound in anesthesiology: national expert recommendations using Delphi methodology
CONCLUSION: Through national expert consensus, this study identified POCUS competencies suitable for curriculum development and assessment in perioperative anesthesiology. Next steps include designing and piloting a POCUS curriculum and assessment tool(s) based upon these nationally defined competencies.PMID:38632162 | DOI:10.1007/s12630-024-02746-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 17, 2024 Category: Anesthesiology Authors: Glenio B Mizubuti Sarah Maxwell Sergiy Shatenko Heather Braund Rachel Phelan Anthony M-H Ho Nancy Dalgarno Hailey Hobbs Adam Szulewski Faizal Haji Ramiro Arellano and the Canadian Anesthesiology POCUS Consortium Source Type: research
Competencies for proficiency in basic point-of-care ultrasound in anesthesiology: national expert recommendations using Delphi methodology
CONCLUSION: Through national expert consensus, this study identified POCUS competencies suitable for curriculum development and assessment in perioperative anesthesiology. Next steps include designing and piloting a POCUS curriculum and assessment tool(s) based upon these nationally defined competencies.PMID:38632162 | DOI:10.1007/s12630-024-02746-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 17, 2024 Category: Anesthesiology Authors: Glenio B Mizubuti Sarah Maxwell Sergiy Shatenko Heather Braund Rachel Phelan Anthony M-H Ho Nancy Dalgarno Hailey Hobbs Adam Szulewski Faizal Haji Ramiro Arellano and the Canadian Anesthesiology POCUS Consortium Source Type: research
Competencies for proficiency in basic point-of-care ultrasound in anesthesiology: national expert recommendations using Delphi methodology
CONCLUSION: Through national expert consensus, this study identified POCUS competencies suitable for curriculum development and assessment in perioperative anesthesiology. Next steps include designing and piloting a POCUS curriculum and assessment tool(s) based upon these nationally defined competencies.PMID:38632162 | DOI:10.1007/s12630-024-02746-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 17, 2024 Category: Anesthesiology Authors: Glenio B Mizubuti Sarah Maxwell Sergiy Shatenko Heather Braund Rachel Phelan Anthony M-H Ho Nancy Dalgarno Hailey Hobbs Adam Szulewski Faizal Haji Ramiro Arellano and the Canadian Anesthesiology POCUS Consortium Source Type: research
Competencies for proficiency in basic point-of-care ultrasound in anesthesiology: national expert recommendations using Delphi methodology
CONCLUSION: Through national expert consensus, this study identified POCUS competencies suitable for curriculum development and assessment in perioperative anesthesiology. Next steps include designing and piloting a POCUS curriculum and assessment tool(s) based upon these nationally defined competencies.PMID:38632162 | DOI:10.1007/s12630-024-02746-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 17, 2024 Category: Anesthesiology Authors: Glenio B Mizubuti Sarah Maxwell Sergiy Shatenko Heather Braund Rachel Phelan Anthony M-H Ho Nancy Dalgarno Hailey Hobbs Adam Szulewski Faizal Haji Ramiro Arellano and the Canadian Anesthesiology POCUS Consortium Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Is remimazolam the elusive anesthetic on/off switch?
Can J Anaesth. 2024 Apr 12. doi: 10.1007/s12630-024-02736-y. Online ahead of print.NO ABSTRACTPMID:38609683 | DOI:10.1007/s12630-024-02736-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 12, 2024 Category: Anesthesiology Authors: J Ross Renew Source Type: research
