MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level
Cancer Biol Ther. 2024 Dec 31;25(1):2345977. doi: 10.1080/15384047.2024.2345977. Epub 2024 Apr 24.ABSTRACTRecent studies have indicated that the tumor immune microenvironment plays a pivotal role in the initiation and progression of clear cell renal cell carcinoma (ccRCC). However, the characteristics and heterogeneity of tumor immunity in ccRCC, particularly at the multiomics level, remain poorly understood. We analyzed immune multiomics datasets to perform a consensus cluster analysis and validate the clustering results across multiple internal and external ccRCC datasets; and identified two distinctive immune phenotypes...
Source: Cancer Biology and Therapy - April 25, 2024 Category: Cancer & Oncology Authors: Ying Liu Lin Qi Bicheng Ye Anbang Wang Juan Lu Le Qu Peng Luo Linhui Wang Aimin Jiang Source Type: research
Significant response to pembrolizumab plus lenvatinib in Epstein-Barr-virus-associated intrahepatic cholangiocarcinoma: a case report
CONCLUSIONS: As far as we know, this is the first case report about the application of Pembrolizumab with lenvatinib for EBVaiCCA patients. This case indicates that the combination of immunotherapy and antiangiogenic therapy provides a glimmer of hope for advanced EBVaiCCA patients.PMID:38650446 | PMC:PMC11042061 | DOI:10.1080/15384047.2024.2338644 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Lisha Li Dandan Yu Jinru Yang Fangyuan Zhang Dejun Zhang Zhenyu Lin Menglan Zhai Jing Wang Tao Zhang Lei Zhao Source Type: research
Significant response to pembrolizumab plus lenvatinib in Epstein-Barr-virus-associated intrahepatic cholangiocarcinoma: a case report
CONCLUSIONS: As far as we know, this is the first case report about the application of Pembrolizumab with lenvatinib for EBVaiCCA patients. This case indicates that the combination of immunotherapy and antiangiogenic therapy provides a glimmer of hope for advanced EBVaiCCA patients.PMID:38650446 | PMC:PMC11042061 | DOI:10.1080/15384047.2024.2338644 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Lisha Li Dandan Yu Jinru Yang Fangyuan Zhang Dejun Zhang Zhenyu Lin Menglan Zhai Jing Wang Tao Zhang Lei Zhao Source Type: research
Significant response to pembrolizumab plus lenvatinib in Epstein-Barr-virus-associated intrahepatic cholangiocarcinoma: a case report
CONCLUSIONS: As far as we know, this is the first case report about the application of Pembrolizumab with lenvatinib for EBVaiCCA patients. This case indicates that the combination of immunotherapy and antiangiogenic therapy provides a glimmer of hope for advanced EBVaiCCA patients.PMID:38650446 | DOI:10.1080/15384047.2024.2338644 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Lisha Li Dandan Yu Jinru Yang Fangyuan Zhang Dejun Zhang Zhenyu Lin Menglan Zhai Jing Wang Tao Zhang Lei Zhao Source Type: research
Understanding and overcoming resistance to immunotherapy in genitourinary cancers
This article presents a comprehensive overview of the mechanisms of immunotherapy resistance in GU cancers as currently described in the literature. It explores studies that have identified genetic markers, cytokines, and proteins that may predict resistance or response to immunotherapy. Additionally, we review current efforts to overcome this resistance, which include combination ICIs and sequential therapies, novel insights into the host immune profile, and new targeted therapies. Various approaches that combine immunotherapy with chemotherapy, targeted therapy, vaccines, and radiation have been studied in an effort to m...
Source: Cancer Biology and Therapy - April 17, 2024 Category: Cancer & Oncology Authors: Sean T Evans Yash Jani Caroline S Jansen Ahmet Yildirim Ecem Kalemoglu Mehmet Asim Bilen Source Type: research
Understanding and overcoming resistance to immunotherapy in genitourinary cancers
This article presents a comprehensive overview of the mechanisms of immunotherapy resistance in GU cancers as currently described in the literature. It explores studies that have identified genetic markers, cytokines, and proteins that may predict resistance or response to immunotherapy. Additionally, we review current efforts to overcome this resistance, which include combination ICIs and sequential therapies, novel insights into the host immune profile, and new targeted therapies. Various approaches that combine immunotherapy with chemotherapy, targeted therapy, vaccines, and radiation have been studied in an effort to m...
Source: Cancer Biology and Therapy - April 17, 2024 Category: Cancer & Oncology Authors: Sean T Evans Yash Jani Caroline S Jansen Ahmet Yildirim Ecem Kalemoglu Mehmet Asim Bilen Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
