Cancers, Vol. 16, Pages 1788: Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice
na Helyes
Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad range of side effects. The mechanisms, mediators and targets need to be identified to determine potential novel therapies. Here, we characterize a mouse bone cancer model induced by intratibial injection of K7M2 osteosarcoma cells using an integrative approach and investigate the role of capsaicin-sensitive peptidergic sensory nerves. The mechanical pain threshold was assessed by dynamic plantar aesthesiometry, limb loading by dynamic weight bearing, sp...
Source: Cancers - May 7, 2024 Category: Cancer & Oncology Authors: No émi Bencze B álint Scheich Éva Szőke Imola Wilhelm S ándor Körmöndi B álint Botz Zsuzsanna Helyes Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1789: Factors Influencing Long-Term Local Recurrence, Distant Metastasis, and Survival in Patients with Soft Tissue Sarcoma of the Extremities Treated with Radiotherapy
Conclusion: RT associated with surgical resection was well tolerated and was associated with excellent long-term rates of LC, DC, and OS. Compared with 3DRT, IMRT improved local control. Liposarcoma was a favorable prognostic factor for OS. Intermediate- and high-grade tumors and deep tumors were associated with lower DC and OS. (Source: Cancers)
Source: Cancers - May 7, 2024 Category: Cancer & Oncology Authors: Arthur Lebas Clara Le Fevre Waisse Waissi Isabelle Chambrelant David Brinkert Georges Noel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1785: Programmed Death Ligand 1 Expression in Circulating Tumor Cells as a Predictor and Monitor of Response to Atezolizumab plus Bevacizumab Treatment in Patients with Hepatocellular Carcinoma
Yasunari Nakamoto
There remains no reliable biomarker of therapeutic efficacy in hepatocellular carcinoma (HCC) for the PD-L1 inhibitor atezolizumab and bevacizumab (Atezo/Bev). Circulating tumor cells (CTCs) enable the serial collection of living tumor cells. Pre-treatment and serial CTC gene expression changes and tumor histology were evaluated to identify predictors of response to Atezo/Bev. Peripheral blood from 22 patients with HCC treated with Atezo/Bev and 24 patients treated with lenvatinib was serially collected. The RNA expression in CTCs was analyzed using qRT-PCR. Higher PD-L1 expression in pre-treatment ...
Source: Cancers - May 6, 2024 Category: Cancer & Oncology Authors: Takuto Nosaka Yosuke Murata Yu Akazawa Tomoko Tanaka Kazuto Takahashi Tatsushi Naito Hidetaka Matsuda Masahiro Ohtani Yoshiaki Imamura Yasunari Nakamoto Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1786: Phytochemical Modulation of Ion Channels in Oncologic Symptomatology and Treatment
Sengupta
Modern chemotherapies offer a broad approach to cancer treatment but eliminate both cancer and non-cancer cells indiscriminately and, thus, are associated with a host of side effects. Advances in precision oncology have brought about new targeted therapeutics, albeit mostly limited to a subset of patients with an actionable mutation. They too come with side effects and, ultimately, ‘self-resistance’ to the treatment. There is recent interest in the modulation of ion channels, transmembrane proteins that regulate the flow of electrically charged molecules in and out of cells, as an ...
Source: Cancers - May 6, 2024 Category: Cancer & Oncology Authors: Rohan Rao Caroline Mohammed Lise Alschuler Daniel A. Pomeranz Krummel Soma Sengupta Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1787: Expression of Potential Antibody & ndash;Drug Conjugate Targets in Cervical Cancer
Conclusions: TROP2, CEACAM5 or CD138 do seem suitable for further clinical research and the data presented here might be used to guide further clinical trials with ADCs in advanced and recurrent cervical cancer patients. (Source: Cancers)
Source: Cancers - May 6, 2024 Category: Cancer & Oncology Authors: Michael R. Mallmann Sina Tamir Katharina Alfter Dominik Ratiu Alexander Quaas Christian M. Domroese Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1782: Spinal Intradural Tumor Resection via Long-Segment Approaches and Clinical Long-Term Follow-Up
Discussion: We achieved satisfying results with long-segment approaches. In general, patients reported pain improvement after surgery and received similar low modified McCormick scores pre- and post surgery and did not undergo secondary dorsal fixation. Thus, we conclude that intradural tumor resection via extensive approaches does not seem to impair long-term spinal stability in our cohort. (Source: Cancers)
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Laura Dieringer Lea Baumgart Laura Schwieren Jens Gempt Maria Wostrack Bernhard Meyer Vicki M. Butenschoen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1783: Two-Year-Span Breast Cancer Screening Uptake in Japan after the COVID-19 Pandemic and Its Association with the COVID-19 Vaccination
We examined the regular breast cancer screening uptake before and after the pandemic and employed a multivariable Poisson regression model to seek any association between COVID-19 vaccination and screening uptake. Of 6110, 38.2% regularly participated in screening before the pandemic and 46.9% did so after the pandemic. Individuals unvaccinated due to health reasons (incidence rate ratio (IRR) = 0.47, 95% CI: 0.29–0.77, p = 0.003) and for other reasons (IRR = 0.73, 95% CI: 0.62–0.86, p < 0.001) were less likely to undergo screening compared to fully vaccinated individuals. There was n...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Aminu Kende Abubakar Yudai Kaneda Akihiko Ozaki Hiroaki Saito Michio Murakami Daisuke Hori Kenji Gonda Masaharu Tsubokura Takahiro Tabuchi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1784: Hypnosis-Assisted Awake Craniotomy for Eloquent Brain Tumors: Advantages and Pitfalls
Conclusion: HAAC is a safe alternative to MAC as it reduces perioperative stress and increases overall satisfaction. Further research is necessary to assess whether hypnosis is clinically beneficial. (Source: Cancers)
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Giulia Cossu Alberto Vandenbulcke Sonia Zaccarini John G. Gaudet Andreas F Hottinger Nina Rimorini Arnaud Potie Valerie Beaud Ursula Guerra-Lopez Roy T Daniel Chantal Berna Mahmoud Messerer Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1777: & ldquo;Seeing Is Believing & rdquo;: Additive Utility of 68Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis
Cancers, Vol. 16, Pages 1777: “Seeing Is Believing”: Additive Utility of 68Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis
Cancers doi: 10.3390/cancers16091777
Authors:
Joel Chin
Yu Guang Tan
Alvin Lee
Tze Kiat Ng
Ruoyu Shi
Charlene Yu Lin Tang
Sue Ping Thang
Jeffrey Kit Loong Tuan
Christopher Wai Sam Cheng
Kae Jack Tay
Henry Sun Sien Ho
Hung-Jen Wang
Peter Ka-Fung Chiu
Jeremy Yuen-Chun Teoh
Winnie Wing-Chuen Lam
Yan Mee Law
John Shyi Peng Yuen
Kenneth Chen
Widespread adoption of mpMRI has led to a decrease in the number of patients requiring prostate biopsies. 6...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Joel Chin Yu Guang Tan Alvin Lee Tze Kiat Ng Ruoyu Shi Charlene Yu Lin Tang Sue Ping Thang Jeffrey Kit Loong Tuan Christopher Wai Sam Cheng Kae Jack Tay Henry Sun Sien Ho Hung-Jen Wang Peter Ka-Fung Chiu Jeremy Yuen-Chun Teoh Winnie Wing-Chuen Lam Yan Mee Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1778: The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis
a
Treglia
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) has been shown to be a non-invasive and promising tool, but apparently, unclear data seem to be present in the literature. This systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[18F]FDG PET/CT and its parameter...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Albano Rizzo Racca Muoio Bertagna Treglia Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1779: Opaganib Downregulates N-Myc Expression and Suppresses In Vitro and In Vivo Growth of Neuroblastoma Cells
D. Smith
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosphate (S1P) by sphingosine kinase-2 and elevating dihydroceramides by inhibition of dihydroceramide desaturase. The present studies sought to determine the potential therapeutic activity of opaganib in cell culture and xenograft models of NB. Cytotoxicity assays demonstrated that NB ...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Lynn W. Maines Staci N. Keller Ryan A. Smith Randy S. Schrecengost Charles D. Smith Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1780: How Immunotherapy Has Redefined the Treatment Paradigm of Metastatic or Locally Advanced Muscle-Invasive Urothelial Bladder Carcinoma
oss-Goupil
In the past decade, the therapeutic arsenal for metastatic bladder cancer has expanded considerably, with the development of immune checkpoint inhibitors (ICIs), antibody–drug conjugates such as enfortumab vedotin, and anti-fibroblast growth factor receptor agents. Clinical trials evaluating ICIs as neoadjuvants, adjuvants, or first- or second-line treatments have produced conflicting results. However, first-line therapeutic strategies have been redefined by the recent publication of results from two clinical trials: CheckMate-901, which demonstrated the superiority of combined treatment with n...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Mathieu Larroquette F élix Lefort Charlotte Domblides Luc H éraudet Gr égoire Robert Alain Ravaud Marine Gross-Goupil Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1781: Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis
This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-based pathway activation scoring method was employed to investigate the expression patterns of these signatures in the mRNA expression profiles of ovarian cancer cohorts. Compared to other subtype tumors, the results of this study show that the Hippo signaling pathway signatures are dysregulated prominently in serous subtype-specific ovarian carcinogenesis. A receiver oper...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Karthik Balakrishnan Yuanhong Chen Jixin Dong Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1776: The Current Role of Radiation in the Management of Cholangiocarcinoma & mdash;A Narrative Review
Cancers, Vol. 16, Pages 1776: The Current Role of Radiation in the Management of Cholangiocarcinoma—A Narrative Review
Cancers doi: 10.3390/cancers16091776
Authors:
Saurav Verma
Natalie Grindrod
Daniel Breadner
Michael Lock
Cholangiocarcinoma (CCA) is a rare cancer of bile ducts. It is associated with a poor prognosis. The incidence of CCA is rising worldwide. Anatomical subgroups have been used to classify patients for treatment and prognosis. There is a growing understanding of clinically important distinctions based on underlying genetic differences that lead to different treatment options and ou...
Source: Cancers - May 4, 2024 Category: Cancer & Oncology Authors: Saurav Verma Natalie Grindrod Daniel Breadner Michael Lock Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1772: Macrophages Orchestrate the Liver Tumor Microenvironment
elli
Liver cancer is one of the leading causes of cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma are the most common types, and despite numerous advances, therapeutic options still remain poor for these cancer patients. Tumor development and progression strictly depend on a supportive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant immune cells population within a tumorigenic liver; they sustain cancer cells’ growth and invasiveness, and their presence is correlated with a poor prognosis. Furthermore, TAM cross-talk with cells and componen...
Source: Cancers - May 4, 2024 Category: Cancer & Oncology Authors: Valeria Quaranta Costanza Ballar ò Gianluigi Giannelli Tags: Review Source Type: research
