NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma
Melanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to ever changing tumor microenvironments. The elucidation of cancer specific... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 6, 2024 Category: Molecular Biology Authors: Lucia Devitt, Dana Westphal, Katharina Pieger, Nadja Schneider, Anja Katrin Bosserhoff and Silke Kuphal Tags: Research Source Type: research
Aberrant activation of TGF- β/ROCK1 enhances stemness during prostatic stromal hyperplasia
Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth factor activation and embryonic reawakening are considered important factors. Here we demonstrated that the aberrant acti... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 6, 2024 Category: Molecular Biology Authors: Youyou Li, Jiaren Li, Liang Zhou, Zhenxing Wang, Ling Jin, Jia Cao, Hui Xie and Long Wang Tags: Research Source Type: research
NCX1/Ca2+ promotes autophagy and decreases bortezomib activity in multiple myeloma through non-canonical NF κB signaling pathway
Although bortezomib (BTZ) is the cornerstone of anti-multiple myeloma (MM) therapy, the inevitable primary and secondary drug resistance still seriously affects the prognosis of patients. New treatment strateg... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 6, 2024 Category: Molecular Biology Authors: Tingting Li, Pingping Xiao, Dongbiao Qiu, Apeng Yang, Qingjiao Chen, Junfang Lin, Yao Liu, Junmin Chen and Zhiyong Zeng Tags: Research Source Type: research
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3R α
IL-3/STAT5 signaling pathway is crucial for the development and activation of immune cells, contributing to the cellular response to infections and inflammatory stimuli. Dysregulation of the IL-3/STAT5 signali... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 3, 2024 Category: Molecular Biology Authors: Jingge Yu, Jianguo Li, Ao Shen, Zhiping Liu and Tian-Sheng He Tags: Research Source Type: research
Signaling, cancer cell plasticity, and intratumor heterogeneity
Cancer ’s complexity is in part due to the presence of intratumor heterogeneity and the dynamic nature of cancer cell plasticity, which create substantial obstacles in effective cancer management. Variability w... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 3, 2024 Category: Molecular Biology Authors: Marco Cordani, Ilaria Dando, Giulia Ambrosini and Pedro Gonz ález-Menéndez Tags: Editorial Source Type: research
Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Steffen Backert, Nicole Tegtmeyer, Anselm H. C. Horn, Heinrich Sticht and Bodo Linz Tags: Brief Report Source Type: research
Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor- α immunotherapy
Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine signaling, including tumor necrosis factor- α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) pathways. The ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Olga A. Sukocheva, Margarita E. Neganova, Yulia Aleksandrova, Jack T. Burcher, Elena Chugunova, Ruitai Fan, Edmund Tse, Gautam Sethi, Anupam Bishayee and Junqi Liu Tags: Review Source Type: research
DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation
Ischemic postconditioning (IPostC) has been reported as a promising method for protecting against myocardial ischemia-reperfusion (MI/R) injury. Our previous study found that the infarct-limiting effect of IPo... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Wei Li, Yan Leng, Yonghong Xiong, Wenyuan Li, Yin Cai, Rui Xue, Rong Chen, Shaoqing Lei, Zhengyuan Xia and Zhongyuan Xia Tags: Research Source Type: research
Correction: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Geriolda Topi, Shakti Ranjan Satapathy, Souvik Ghatak, Karin Hellman, Fredrik Ek, Roger Olsson, Roy Ehrnstr öm, Marie-Louise Lydrup and Anita Sjölander Tags: Correction Source Type: research
Cuproptosis: unveiling a new frontier in cancer biology and therapeutics
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptos... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 1, 2024 Category: Molecular Biology Authors: Ying Feng, Zhibo Yang, Jianpeng Wang and Hai Zhao Tags: Review Source Type: research
The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 30, 2024 Category: Molecular Biology Authors: Qianyi Bao, Anyu Wang, Wenxuan Hong, Yushu Wang, Baojie Li, Lin He, Xiaodong Yuan and Gang Ma Tags: Research Source Type: research
Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling
Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 30, 2024 Category: Molecular Biology Authors: Lap Hing Chi, Andrew D. Redfern, Suraya Roslan, Ian P. Street, Allan D. Burrows and Robin L. Anderson Tags: Research Source Type: research
PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation
Paired box 1 (PAX1) is a transcription factor and essential for the development of pharyngeal pouches-derived tissues, including thymus. PAX1 mutations are identified in Severe Combined Immunodeficiency (SCID)... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 26, 2024 Category: Molecular Biology Authors: Danxiu Miao, Jie Ren, Yanhan Jia, Yihui Jia, Yanshu Li, Huizhe Huang and Rui Gao Tags: Research Source Type: research
Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
Coronary artery disease (CAD) is a leading cause of death in women. Epicardial adipose tissue (EAT) secretes cytokines to modulate coronary artery function, and the release of fatty acids from EAT serves as a ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 26, 2024 Category: Molecular Biology Authors: Irshad Ahmad, Shreyan Gupta, Patricia Faulkner, Destiny Mullens, Micah Thomas, Sharanee P. Sytha, Ivan Ivanov, James J. Cai, Cristine L. Heaps and Annie E. Newell-Fugate Tags: Research Source Type: research
Targeting Wnt/ β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of pathways such as the transforming growth factor-beta (TGF- β), Notc... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 26, 2024 Category: Molecular Biology Authors: Dimakatso B. Gumede, Heidi Abrahamse and Nicolette N. Houreld Tags: Review Source Type: research
