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Update in genetic and epigenetic causes of hypertension
Cell Mol Life Sci. 2024 Apr 30;81(1):201. doi: 10.1007/s00018-024-05220-4.ABSTRACTHypertension is a heritable disease that affects one-fourth of the population and accounts for about 50% of cardiovascular deaths. The genetic basis of hypertension is multifaceted, involving both monogenic and most commonly complex polygenic forms. With the advent of the human genome project, genome-wide association studies (GWAS) have identified a plethora of loci linked to hypertension by examining common genetic variations. It's notable, however, that the majority of these genetic variants do not affect the protein-coding sequences, posin...
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Arya Mani Source Type: research

Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models
In conclusion, the deficiency of the nuclear hormone receptor nhr-210 in alpha-synuclein expressing strain of C. elegans, results in altered mitochondrial function, coupled with alterations in vital metabolite levels. These findings underline the functional and physiological importance of nhr-210 enrichment in CEPsh glia.PMID:38691171 | DOI:10.1007/s00018-024-05179-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Rohil Hameed Anam Naseer Ankit Saxena Mahmood Akbar Pranoy Toppo Arunabh Sarkar Sanjeev K Shukla Aamir Nazir Source Type: research

Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
In conclusion, there is a crosstalk between TYK2 and TLR7 mediated by an IFN-I feedback loop, which contributes to the establishment of MZ B cells and to B cell proliferation and differentiation.PMID:38683377 | PMC:PMC11058799 | DOI:10.1007/s00018-024-05234-y (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Irene Bodega-Mayor Pablo Delgado-Wicke Alejandro Arrabal Est íbaliz Alegría-Carrasco Ana Nicolao-G ómez Marta Ja én-Castaño Cristina Espadas Ana Dopazo Enrique Mart ín-Gayo Mar ía Luisa Gaspar Bel én de Andrés Elena Fern ández-Ruiz Source Type: research

Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | PMC:PMC11058795 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research

Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
In conclusion, there is a crosstalk between TYK2 and TLR7 mediated by an IFN-I feedback loop, which contributes to the establishment of MZ B cells and to B cell proliferation and differentiation.PMID:38683377 | DOI:10.1007/s00018-024-05234-y (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Irene Bodega-Mayor Pablo Delgado-Wicke Alejandro Arrabal Est íbaliz Alegría-Carrasco Ana Nicolao-G ómez Marta Ja én-Castaño Cristina Espadas Ana Dopazo Enrique Mart ín-Gayo Mar ía Luisa Gaspar Bel én de Andrés Elena Fern ández-Ruiz Source Type: research

Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research

Molecular mechanisms and therapeutic strategies for neuromuscular diseases
Cell Mol Life Sci. 2024 Apr 28;81(1):198. doi: 10.1007/s00018-024-05229-9.ABSTRACTNeuromuscular diseases encompass a heterogeneous array of disorders characterized by varying onset ages, clinical presentations, severity, and progression. While these conditions can stem from acquired or inherited causes, this review specifically focuses on disorders arising from genetic abnormalities, excluding metabolic conditions. The pathogenic defect may primarily affect the anterior horn cells, the axonal or myelin component of peripheral nerves, the neuromuscular junction, or skeletal and/or cardiac muscles. While inherited neuromuscu...
Source: Cellular and Molecular Life Sciences : CMLS - April 28, 2024 Category: Cytology Authors: Zambon Alberto Andrea Falzone Yuri Matteo Bolino Alessandra Previtali Stefano Carlo Source Type: research

Engineered platforms for mimicking cardiac development and drug screening
Cell Mol Life Sci. 2024 Apr 25;81(1):197. doi: 10.1007/s00018-024-05231-1.ABSTRACTCongenital heart defects are associated with significant health challenges, demanding a deep understanding of the underlying biological mechanisms and, thus, better devices or platforms that can recapitulate human cardiac development. The discovery of human pluripotent stem cells has substantially reduced the dependence on animal models. Recent advances in stem cell biology, genetic editing, omics, microfluidics, and sensor technologies have further enabled remarkable progress in the development of in vitro platforms with increased fidelity a...
Source: Cellular and Molecular Life Sciences : CMLS - April 25, 2024 Category: Cytology Authors: Madison Stiefbold Haokang Zhang Leo Q Wan Source Type: research

Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes
In this study, we employed an inducible CRISPRi human induced pluripotent stem cell (hiPSC) line to silence TERT expression enabling the generation of hiPSCs and hiPSC-derived cardiomyocytes with long and short telomeres. Reduced telomerase activity and shorter telomere lengths of hiPSCs induced global transcriptomic changes associated with cardiac developmental pathways. Consequently, the differentiation potential towards cardiomyocytes was strongly impaired and single cell RNA sequencing revealed a shift towards a more smooth muscle cell like identity in the cells with the shortest telomeres. Poor cardiomyocyte function ...
Source: Cellular and Molecular Life Sciences : CMLS - April 24, 2024 Category: Cytology Authors: Shambhabi Chatterjee Megan Leach-Mehrwald Cheng-Kai Huang Ke Xiao Maximilian Fuchs Mandy Otto Dongchao Lu Vinh Dang Thomas Winkler Cynthia E Dunbar Thomas Thum Christian B är Source Type: research

Involvement of the glymphatic/meningeal lymphatic system in Alzheimer's disease: insights into proteostasis and future directions
Cell Mol Life Sci. 2024 Apr 23;81(1):192. doi: 10.1007/s00018-024-05225-z.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is pathologically characterized by the abnormal accumulation of Aβ and tau proteins. There has long been a keen interest among researchers in understanding how Aβ and tau are ultimately cleared in the brain. The discovery of this glymphatic system introduced a novel perspective on protein clearance and it gained recognition as one of the major brain clearance pathways for clearing these pathogenic proteins in AD. This finding has sparked interest in exploring the potential contribution of the glymphatic...
Source: Cellular and Molecular Life Sciences : CMLS - April 23, 2024 Category: Cytology Authors: Kaoru Yamada Takeshi Iwatsubo Source Type: research

Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14
Cell Mol Life Sci. 2024 Apr 23;81(1):191. doi: 10.1007/s00018-024-05221-3.ABSTRACTLipopolysaccharide (LPS) induces a strong pro-inflammatory reaction of macrophages upon activation of Toll-like receptor 4 (TLR4) with the assistance of CD14 protein. Considering a key role of plasma membrane rafts in CD14 and TLR4 activity and the significant impact exerted on that activity by endocytosis and intracellular trafficking of the both LPS acceptors, it seemed likely that the pro-inflammatory reaction could be modulated by flotillins. Flotillin-1 and -2 are scaffolding proteins associated with the plasma membrane and also with end...
Source: Cellular and Molecular Life Sciences : CMLS - April 23, 2024 Category: Cytology Authors: Orest V Matveichuk Anna Ciesielska Aneta Hromada-Judycka Natalia Nowak Ichrak Ben Amore Gabriela Traczyk Katarzyna Kwiatkowska Source Type: research

The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases
Cell Mol Life Sci. 2024 Apr 23;81(1):193. doi: 10.1007/s00018-024-05227-x.ABSTRACTThe acetylation of α-tubulin on lysine 40 is a well-studied post-translational modification which has been associated with the presence of long-lived stable microtubules that are more resistant to mechanical breakdown. The discovery of α-tubulin acetyltransferase 1 (ATAT1), the enzyme responsible for lysine 40 acetylation on α-tubulin in a wide range of species, including protists, nematodes, and mammals, dates to about a decade ago. However, the role of ATAT1 in different cellular activities and molecular pathways has been only recently d...
Source: Cellular and Molecular Life Sciences : CMLS - April 23, 2024 Category: Cytology Authors: Angela Iuzzolino Francesca Romana Pellegrini Dante Rotili Francesca Degrassi Daniela Trisciuoglio Source Type: research