Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Cell Mol Neurobiol. 2024 Apr 26;44(1):42. doi: 10.1007/s10571-024-01472-7.ABSTRACTLewy Body Dementias (LBD), including Parkinson's disease dementia and Dementia with Lewy Bodies, are characterized by widespread accumulation of intracellular alpha-Synuclein protein deposits in regions beyond the brainstem, including in the cortex. However, the impact of local pathology in the cortex is unknown. To investigate this, we employed viral overexpression of human alpha-Synuclein protein targeting the mouse prefrontal cortex (PFC). We then used in vivo 2-photon microscopy to image awake head-fixed mice via an implanted chronic cran...
Source: Cellular and Molecular Neurobiology - April 26, 2024 Category: Cytology Authors: Peter J Bosch Gemma Kerr Rachel Cole Charles A Warwick Linder H Wendt Akash Pradeep Emma Bagnall Georgina M Aldridge Source Type: research

Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
Cell Mol Neurobiol. 2024 Apr 24;44(1):41. doi: 10.1007/s10571-024-01476-3.ABSTRACTThe cadherin family plays a pivotal role in orchestrating synapse formation in the central nervous system. Cadherin-related family member 1 (CDHR1) is a photoreceptor-specific calmodulin belonging to the expansive cadherin superfamily. However, its role in traumatic brain injury (TBI) remains largely unknown. CDHR1 expression across various brain tissue sites was analyzed using the GSE104687 dataset. Employing a summary-data-based Mendelian Randomization (SMR) approach, integrated analyses were performed by amalgamating genome-wide associatio...
Source: Cellular and Molecular Neurobiology - April 24, 2024 Category: Cytology Authors: Yong'An Jiang Peng Chen YangYang Zhao Yan Zhang Source Type: research

Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Cell Mol Neurobiol. 2024 Apr 24;44(1):40. doi: 10.1007/s10571-024-01475-4.NO ABSTRACTPMID:38656458 | PMC:PMC11043160 | DOI:10.1007/s10571-024-01475-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 24, 2024 Category: Cytology Authors: Tongyu Zhang Gang Zuo Hongqi Zhang Source Type: research

Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Cell Mol Neurobiol. 2024 Apr 24;44(1):40. doi: 10.1007/s10571-024-01475-4.NO ABSTRACTPMID:38656458 | DOI:10.1007/s10571-024-01475-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 24, 2024 Category: Cytology Authors: Tongyu Zhang Gang Zuo Hongqi Zhang Source Type: research

Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
Cell Mol Neurobiol. 2024 Apr 22;44(1):37. doi: 10.1007/s10571-024-01479-0.NO ABSTRACTPMID:38647721 | PMC:PMC11035384 | DOI:10.1007/s10571-024-01479-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 22, 2024 Category: Cytology Authors: Alejandra Infante Cruz Juan Valentin Coronel Paula Saibene V élez Federico Remes Lenicov Juan Iturrizaga Mart ín Abelleyro Micaela Rosato Carolina Maiumi Shiromizu Marianela Candolfi M ónica Vermeulen Carolina Jancic Ezequiel Yasuda Silvia Berner Marce Source Type: research

Correction: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
Cell Mol Neurobiol. 2024 Apr 22;44(1):38. doi: 10.1007/s10571-024-01477-2.NO ABSTRACTPMID:38647722 | PMC:PMC11035397 | DOI:10.1007/s10571-024-01477-2 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 22, 2024 Category: Cytology Authors: Yuchen Li Pei Wu Jiaxing Dai Tongyu Zhang Ji Bihl Chunlei Wang Yao Liu Huaizhang Shi Source Type: research

Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury
The objective of this study was to characterize the differential gene expression and molecular mechanisms in the spinal cord of mice three days after spinal cord injury. By analyzing RNA sequencing data, we identified differentially expressed genes and discovered that the immune system and various metabolic processes play crucial roles in SCI. Additionally, we identified UHRF1 as a key gene that plays a significant role in SCI and found that SCI can be improved by suppressing UHRF1. These findings provide important insights into the molecular mechanisms of SCI and identify potential therapeutic targets that could greatly c...
Source: Cellular and Molecular Neurobiology - April 22, 2024 Category: Cytology Authors: Shuai Cheng Hui Guo Mingyu Bai Yang Cui He Tian Xifan Mei Source Type: research

Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research