Macrophage niche imprinting as a determinant of macrophage identity and function
Cell Immunol. 2024 Apr 20;399-400:104825. doi: 10.1016/j.cellimm.2024.104825. Online ahead of print.ABSTRACTMacrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between ...
Source: Cellular Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Malgorzata Kloc Marta Halasa Rafik M Ghobrial Source Type: research
Macrophage niche imprinting as a determinant of macrophage identity and function
Cell Immunol. 2024 Apr 20;399-400:104825. doi: 10.1016/j.cellimm.2024.104825. Online ahead of print.ABSTRACTMacrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between ...
Source: Cellular Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Malgorzata Kloc Marta Halasa Rafik M Ghobrial Source Type: research
Macrophage niche imprinting as a determinant of macrophage identity and function
Cell Immunol. 2024 Apr 20;399-400:104825. doi: 10.1016/j.cellimm.2024.104825. Online ahead of print.ABSTRACTMacrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between ...
Source: Cellular Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Malgorzata Kloc Marta Halasa Rafik M Ghobrial Source Type: research
Development of innate and adaptive immunity to RSV in young children
Cell Immunol. 2024 Mar 26;399-400:104824. doi: 10.1016/j.cellimm.2024.104824. Online ahead of print.ABSTRACTInfection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a patho...
Source: Cellular Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Emily L Parsons Jisung S Kim Allison M W Malloy Source Type: research
Development of innate and adaptive immunity to RSV in young children
Cell Immunol. 2024 Mar 26;399-400:104824. doi: 10.1016/j.cellimm.2024.104824. Online ahead of print.ABSTRACTInfection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a patho...
Source: Cellular Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Emily L Parsons Jisung S Kim Allison M W Malloy Source Type: research
Development of innate and adaptive immunity to RSV in young children
Cell Immunol. 2024 Mar 26;399-400:104824. doi: 10.1016/j.cellimm.2024.104824. Online ahead of print.ABSTRACTInfection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a patho...
Source: Cellular Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Emily L Parsons Jisung S Kim Allison M W Malloy Source Type: research
Development of innate and adaptive immunity to RSV in young children
Cell Immunol. 2024 Mar 26;399-400:104824. doi: 10.1016/j.cellimm.2024.104824. Online ahead of print.ABSTRACTInfection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a patho...
Source: Cellular Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Emily L Parsons Jisung S Kim Allison M W Malloy Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
Cell Immunol. 2024 Mar 19;399-400:104823. doi: 10.1016/j.cellimm.2024.104823. Online ahead of print.ABSTRACTAAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice. No significant differences were noted in anti-transgene product/ anti-AAV ...
Source: Cellular Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Justin D Glenn Henos Negash William Henry Randolph Qian Ye Liu Olivier Danos Joseph T Bruder Subha Karumuthil-Melethil Source Type: research
