Non-ionotropic voltage-gated calcium channel signaling
Channels (Austin). 2024 Dec;18(1):2341077. doi: 10.1080/19336950.2024.2341077. Epub 2024 Apr 11.ABSTRACTVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways independently of ion flow. This non-ionotropic signaling mode plays a pivotal role in excitation-coupling processes, including gene transcription through excitation-transcription (ET), synaptic transmission via excitation-secretion (ES), and cardiac contraction through excitation-...
Source: Channels - April 11, 2024 Category: Molecular Biology Authors: Michael Trus Daphne Atlas Source Type: research
Non-ionotropic voltage-gated calcium channel signaling
Channels (Austin). 2024 Dec;18(1):2341077. doi: 10.1080/19336950.2024.2341077. Epub 2024 Apr 11.ABSTRACTVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways independently of ion flow. This non-ionotropic signaling mode plays a pivotal role in excitation-coupling processes, including gene transcription through excitation-transcription (ET), synaptic transmission via excitation-secretion (ES), and cardiac contraction through excitation-...
Source: Channels - April 11, 2024 Category: Molecular Biology Authors: Michael Trus Daphne Atlas Source Type: research
Novel protocol for multiple-dose oral administration of the L-type Ca < sup > 2+ < /sup > channel blocker isradipine in mice: A dose-finding pharmacokinetic study
Channels (Austin). 2024 Dec;18(1):2335469. doi: 10.1080/19336950.2024.2335469. Epub 2024 Apr 2.ABSTRACTStudies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ channel blockers serves as an important pharmacological tool. These drugs have a short plasma half-life in humans and especially in rodents and show high first-pass metabolism upon oral application. In the vast majority of in vivo studies, ...
Source: Channels - April 2, 2024 Category: Molecular Biology Authors: Tamara Theiner Nadine J Ortner Herbert Oberacher Gospava Stojanovic Petronel Tuluc J örg Striessnig Source Type: research
