Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5
Chem Biol Interact. 2024 Apr 26;395:111010. doi: 10.1016/j.cbi.2024.111010. Online ahead of print.ABSTRACTThe incidence and mortality rate of myocardial infarction are increasing per year in China. The polarization of macrophages towards the classically activated macrophages (M1) phenotype is of utmost importance in the progression of inflammatory stress subsequent to myocardial infarction. Poly (ADP-ribose) polymerase 1(PARP1) is the ubiquitous and best characterized member of the PARP family, which has been reported to support macrophage polarization towards the pro-inflammatory phenotype. Yet, the role of PARP1 in myoca...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Jia-Ming Luo Hong-Bin Lin Ya-Qian Weng Ying-Hui Lin Lu-Ying Lai Ji Li Feng-Xian Li Shi-Yuan Xu Hong-Fei Zhang Wei Zhao Source Type: research
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models
Chem Biol Interact. 2024 Apr 26:111026. doi: 10.1016/j.cbi.2024.111026. Online ahead of print.ABSTRACTIn the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach involving piribedil and butylated hydroxytoluene lead compounds. To evaluate the antioxidant and neuroprotective activities of the arylpiperazine derivatives, we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (neurotoxicity induced by 3-nitropropionic acid...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Hericles Mesquita Campos Robbert Mota Pereira P âmela Yasmin de Oliveira Ferreira Nkaa Uchenna C ínthia Rio Branco da Silva Letizia Pruccoli Germ án Sanz Marcella Ferreira Rodrigues Boniek Gontijo Vaz B árbara Gonçalves Rivello Andr é Luís Batista Source Type: research
Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5
Chem Biol Interact. 2024 Apr 26;395:111010. doi: 10.1016/j.cbi.2024.111010. Online ahead of print.ABSTRACTThe incidence and mortality rate of myocardial infarction are increasing per year in China. The polarization of macrophages towards the classically activated macrophages (M1) phenotype is of utmost importance in the progression of inflammatory stress subsequent to myocardial infarction. Poly (ADP-ribose) polymerase 1(PARP1) is the ubiquitous and best characterized member of the PARP family, which has been reported to support macrophage polarization towards the pro-inflammatory phenotype. Yet, the role of PARP1 in myoca...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Jia-Ming Luo Hong-Bin Lin Ya-Qian Weng Ying-Hui Lin Lu-Ying Lai Ji Li Feng-Xian Li Shi-Yuan Xu Hong-Fei Zhang Wei Zhao Source Type: research
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models
Chem Biol Interact. 2024 Apr 26:111026. doi: 10.1016/j.cbi.2024.111026. Online ahead of print.ABSTRACTIn the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach involving piribedil and butylated hydroxytoluene lead compounds. To evaluate the antioxidant and neuroprotective activities of the arylpiperazine derivatives, we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (neurotoxicity induced by 3-nitropropionic acid...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Hericles Mesquita Campos Robbert Mota Pereira P âmela Yasmin de Oliveira Ferreira Nkaa Uchenna C ínthia Rio Branco da Silva Letizia Pruccoli Germ án Sanz Marcella Ferreira Rodrigues Boniek Gontijo Vaz B árbara Gonçalves Rivello Andr é Luís Batista Source Type: research
Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5
Chem Biol Interact. 2024 Apr 26:111010. doi: 10.1016/j.cbi.2024.111010. Online ahead of print.ABSTRACTThe incidence and mortality rate of myocardial infarction are increasing per year in China. The polarization of macrophages towards the classically activated macrophages (M1) phenotype is of utmost importance in the progression of inflammatory stress subsequent to myocardial infarction. Poly(ADP-ribose) polymerase 1(PARP1) is the ubiquitous and best characterized member of the PARP family, which has been reported to support macrophage polarization towards the pro-inflammatory phenotype. Yet, the role of PARP1 in myocardial...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Jia-Ming Luo Hong-Bin Lin Ya-Qian Weng Ying-Hui Lin Lu-Ying Lai Ji Li Feng-Xian Li Shi-Yuan Xu Hong-Fei Zhang Wei Zhao Source Type: research
A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models
Chem Biol Interact. 2024 Apr 26:111026. doi: 10.1016/j.cbi.2024.111026. Online ahead of print.ABSTRACTIn the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach involving piribedil and butylated hydroxytoluene lead compounds. To evaluate the antioxidant and neuroprotective activities of the arylpiperazine derivatives, we employed an integrated approach using both in vitro (SH-SY5Y cells) and in vivo (neurotoxicity induced by 3-nitropropionic acid...
Source: Chemico-Biological Interactions - April 28, 2024 Category: Molecular Biology Authors: Hericles Mesquita Campos Robbert Mota Pereira P âmela Yasmin de Oliveira Ferreira Nkaa Uchenna C ínthia Rio Branco da Silva Letizia Pruccoli Germ án Sanz Marcella Ferreira Rodrigues Boniek Gontijo Vaz B árbara Gonçalves Rivello Andr é Luís Batista Source Type: research
Inhibition of Human UDP-Glucuronosyltransferase Enzyme by Entrectinib: Implications for Drug-Drug Interactions
Chem Biol Interact. 2024 Apr 25:111023. doi: 10.1016/j.cbi.2024.111023. Online ahead of print.ABSTRACTAs a new type of oral tyrosine kinase inhibitor, entrectinib can act on multiple targets and exert efficacy and has been approved for the treatment of non-small cell lung cancer (NSCLC) and solid tumors. However, whether entrectinib affects the activities of recombinant human UDP-glucuronosyltransferases (UGTs) remains unclear. Herein, we aimed to investigate the inhibitory effects of entrectinib on human UGTs and to assess the potential risk of causing drug-drug interactions (DDIs) based on the inhibition against UGTs. Hi...
Source: Chemico-Biological Interactions - April 27, 2024 Category: Molecular Biology Authors: Hang Yin Zhe Wang Xin Lv Zhen Wang Ying Wang Wenxuan Fan Shuang Li Lili Jiang Jun Cao Yong Liu Source Type: research
Novel insights into the protective effects of leonurine against acute kidney injury: inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway
This study aimed to explore the benefits of leonurine on AKI and the possible mechanisms involved, mainly focusing on the regulation of ferroptosis and endoplasmic reticulum (ER) stress. Our results showed that leonurine exhibited prominent protective effects against AKI, as evidenced by the amelioration of histopathological alterations and reduction of renal dysfunction. In addition, leonurine significantly suppressed ferroptosis in AKI both in vivo and in vitro by effectively restoring ultrastructural abnormalities in mitochondria, decreasing ASCL4 and 4-HNE levels, scavenging reactive oxygen species (ROS), as well as in...
Source: Chemico-Biological Interactions - April 26, 2024 Category: Molecular Biology Authors: Ran Cheng Xiaowan Wang Lihua Huang Zhisheng Lu Aijun Wu Shan Guo Chuang Li Wei Mao Ying Xie Peng Xu Ruimin Tian Source Type: research
Novel insights into the protective effects of leonurine against acute kidney injury: inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway
This study aimed to explore the benefits of leonurine on AKI and the possible mechanisms involved, mainly focusing on the regulation of ferroptosis and endoplasmic reticulum (ER) stress. Our results showed that leonurine exhibited prominent protective effects against AKI, as evidenced by the amelioration of histopathological alterations and reduction of renal dysfunction. In addition, leonurine significantly suppressed ferroptosis in AKI both in vivo and in vitro by effectively restoring ultrastructural abnormalities in mitochondria, decreasing ASCL4 and 4-HNE levels, scavenging reactive oxygen species (ROS), as well as in...
Source: Chemico-Biological Interactions - April 26, 2024 Category: Molecular Biology Authors: Ran Cheng Xiaowan Wang Lihua Huang Zhisheng Lu Aijun Wu Shan Guo Chuang Li Wei Mao Ying Xie Peng Xu Ruimin Tian Source Type: research
Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells
This study aimed to evaluate the therapeutic efficacy of lipopolysaccharide-coupled clodronate liposomes (LPS-CLD-lipos) and the effects of liposomes size on hepatic fibrosis. Three rat models of hepatic fibrosis were established in vivo; diethylnitrosamine (DEN), bile duct ligation (BDL), and carbon tetrachloride (CCl4). Hematoxylin and eosin staining and serological liver function indices were used to analyze pathological liver damage. Masson's trichrome and Sirius red staining were used to evaluate the effect of liposomes on liver collagen fibers. The hydroxyproline content in liver tissues was determined. In vitro cell...
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Luyao Zhang Min Tao Hengyan Zhang Shichao Zhang Xiaojuan Hou Chen Zong Gangqi Sun Shiyao Feng Haixin Yan Ying Lu Xue Yang Lixin Wei Li Zhang Source Type: research
Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation
In conclusion, nitazoxanide protects against DSS-induced ulcerative colitis in mice through improving intestinal barrier and inhibiting inflammation and the underlying mechanism involves AMPK activation and JAK2/STAT3 inhibition.PMID:38663798 | DOI:10.1016/j.cbi.2024.111013 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Hu-Tai-Long Zhu Jing Luo Yi Peng Xiao-Fan Cheng Shang-Ze Wu Yin-Di Zhao Le Chang Zhi-Jie Sun De-Li Dong Source Type: research
Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells
This study aimed to evaluate the therapeutic efficacy of lipopolysaccharide-coupled clodronate liposomes (LPS-CLD-lipos) and the effects of liposomes size on hepatic fibrosis. Three rat models of hepatic fibrosis were established in vivo; diethylnitrosamine (DEN), bile duct ligation (BDL), and carbon tetrachloride (CCl4). Hematoxylin and eosin staining and serological liver function indices were used to analyze pathological liver damage. Masson's trichrome and Sirius red staining were used to evaluate the effect of liposomes on liver collagen fibers. The hydroxyproline content in liver tissues was determined. In vitro cell...
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Luyao Zhang Min Tao Hengyan Zhang Shichao Zhang Xiaojuan Hou Chen Zong Gangqi Sun Shiyao Feng Haixin Yan Ying Lu Xue Yang Lixin Wei Li Zhang Source Type: research
Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation
In conclusion, nitazoxanide protects against DSS-induced ulcerative colitis in mice through improving intestinal barrier and inhibiting inflammation and the underlying mechanism involves AMPK activation and JAK2/STAT3 inhibition.PMID:38663798 | DOI:10.1016/j.cbi.2024.111013 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Hu-Tai-Long Zhu Jing Luo Yi Peng Xiao-Fan Cheng Shang-Ze Wu Yin-Di Zhao Le Chang Zhi-Jie Sun De-Li Dong Source Type: research
Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation
In conclusion, our study provides solid evidence for both, the immune disruptive potential and the existence of cumulative effects of real nature EDC mixtures on T cell in vitro differentiation.PMID:38653352 | DOI:10.1016/j.cbi.2024.111011 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 23, 2024 Category: Molecular Biology Authors: Florence Fischer Miriam Rebecca Ermer Julia Howanski Ziran Yin Mario Bauer Marita Wagner Beate Fink Ana C Zenclussen Anne Schumacher Source Type: research
Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation
In conclusion, our study provides solid evidence for both, the immune disruptive potential and the existence of cumulative effects of real nature EDC mixtures on T cell in vitro differentiation.PMID:38653352 | DOI:10.1016/j.cbi.2024.111011 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 23, 2024 Category: Molecular Biology Authors: Florence Fischer Miriam Rebecca Ermer Julia Howanski Ziran Yin Mario Bauer Marita Wagner Beate Fink Ana C Zenclussen Anne Schumacher Source Type: research
