Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying Chelidonium majus L. in the treatment of allergic asthma
Chelidonium majus is a well-known traditional Chinese medicine, and has been reported of the effect in relieving cough and asthma. However, the mechanism of action is still unknown. (Source: Chinese Medicine)
Source: Chinese Medicine - April 26, 2024 Category: Complementary Medicine Authors: Renguang Wang, Xintong Sui, Xin Dong, Liming Hu, Zhimeng Li, Hang Yu, Cuicui Li, Guoxin Ji and Shumin Wang Tags: Research Source Type: research
Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometry
As one of the most famous natural products, salvianolic acid A (SAA) is undergoing clinical trials for the treatments of angina pectoris and coronary heart disorders. However, the in vivo metabolites of SAA ha... (Source: Chinese Medicine)
Source: Chinese Medicine - April 26, 2024 Category: Complementary Medicine Authors: Han Li, Ke Zhang, Wei Chen, Yuxuan Zhou, Jun Li, Yunfang Zhao and Yuelin Song Tags: Research Source Type: research
“Qi Nan” agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway
Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus, contributing to end-stage renal disease with limited treatment options. The development of DKD is attributed to podocyte inju... (Source: Chinese Medicine)
Source: Chinese Medicine - April 23, 2024 Category: Complementary Medicine Authors: Ning Li, Xuenan Liu, Hao Wang, Yingling Duan, Yu Zhang, Ping Zhou, Haofu Dai and Tian Lan Tags: Research Source Type: research
Compound Shenma Jingfu granule alleviates cerebral ischemia via HIF-1 α-mediated promotion of angiogenesis
Shenma Jingfu Granule, a traditional Chinese medicine formula, has been used clinically for the treatment of cerebral circulation insufficiency. However, the mechanism involved in alleviating cerebral ischemia... (Source: Chinese Medicine)
Source: Chinese Medicine - April 10, 2024 Category: Complementary Medicine Authors: Ruihua He, Yi Xu, Jingxue Liu, Jing Liu, Jing Chen, Xufang Wang, Lei Qiu and Jin Huang Tags: Research Source Type: research
Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP
Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development and progression of age-related metabolic diseases. Bazi Bushen (BZBS), a traditional C... (Source: Chinese Medicine)
Source: Chinese Medicine - April 9, 2024 Category: Complementary Medicine Authors: Xiaogang Shen, Mengnan Li, Yawen Li, Yuning Jiang, Kunxu Niu, Shixiong Zhang, Xuan Lu, Runtao Zhang, Zhiqin Zhao, Liangxing Zhou, Zhifang Guo, Siwei Wang, Cong Wei, Liping Chang, Yunlong Hou and Yiling Wu Tags: Research Source Type: research
Oleuropein alleviates myocardial ischemia –reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway
Myocardial ischemia/reperfusion injury (MIRI) is an important complication of reperfusion therapy, and has a lack of effective prevention and treatment methods. Oleuropein (OP) is a natural strong antioxidant ... (Source: Chinese Medicine)
Source: Chinese Medicine - April 8, 2024 Category: Complementary Medicine Authors: Jia He, Liting Huang, Kaili Sun, Jilang Li, Shan Han, Xiang Gao, Qin-Qin Wang, Shilin Yang, Wen Sun and Hongwei Gao Tags: Research Source Type: research
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin
Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological pr... (Source: Chinese Medicine)
Source: Chinese Medicine - April 8, 2024 Category: Complementary Medicine Authors: Qian Zeng, Bin-bin Wen, Xin Liu, Yong-yu Luo, Zhen-gang Hu, Lei Huang, Xiao-hua Zhang, Xiao-ting Huang, Ting-ting Zhou, Xiao-xue Sang, Yu-yang Luo, Da-yan Xiong, Zi-qiang Luo, Wei Liu and Si-yuan Tang Tags: Research Source Type: research
Danggui Sini decoction alleviates oxaliplatin-induced peripheral neuropathy by regulating gut microbiota and potentially relieving neuroinflammation related metabolic disorder
Danggui Sini decoction (DSD), a traditional Chinese medicine formula, has the function of nourishing blood, warming meridians, and unblocking collaterals. Our clinical and animal studies had shown that DSD can... (Source: Chinese Medicine)
Source: Chinese Medicine - April 7, 2024 Category: Complementary Medicine Authors: Chen Chen, Jian-Lin Xu, Zhan-Cheng Gu, Shan-Shan Zhou, Guo-Li Wei, Jia-Lin Gu, Hai-Long Ma, Yan-Qi Feng, Zi-Wei Song, Zhan-Peng Yan, Shan Deng, Rong Ding, Song-Lin Li and Jie-Ge Huo Tags: Research Source Type: research
Natural products as potential drug treatments for acute promyelocytic leukemia
Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxi... (Source: Chinese Medicine)
Source: Chinese Medicine - April 3, 2024 Category: Complementary Medicine Authors: Jiaxin Chen and Zuoqi Ding Tags: Review Source Type: research
Medicinal plants and natural products for treating overactive bladder
Overactive bladder (OAB) presents a high prevalence of 16 –18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, med... (Source: Chinese Medicine)
Source: Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Huanxian Chen, Maggie Pui Man Hoi and Simon Ming Yuen Lee Tags: Review Source Type: research
Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). (Source: Chinese Medicine)
Source: Chinese Medicine - March 25, 2024 Category: Complementary Medicine Authors: Tianming Lu, Lirun Zhou, Zheng Chu, Yang Song, Qixin Wang, Minghong Zhao, Chuanhao Dai, Lin Chen, Guangqing Cheng, Jigang Wang and Qiuyan Guo Tags: Research Source Type: research
Formononetin reverses Treg/Th17 imbalance in immune-mediated bone marrow failure mice by regulating the PI3K/Akt signaling pathway
Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cel... (Source: Chinese Medicine)
Source: Chinese Medicine - March 25, 2024 Category: Complementary Medicine Authors: Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang and Lingling Zhu Tags: Research Source Type: research
Total iridoid glycoside extract of Lamiophlomis rotata (Benth) Kudo accelerates diabetic wound healing by the NRF2/COX2 axis
Lamiophlomis rotata (Benth.) Kudo (L. rotata), the oral Traditional Tibetan herbal medicine, is adopted for treating knife and gun wounds for a long time. As previously demonstrated, total iridoid glycoside extra... (Source: Chinese Medicine)
Source: Chinese Medicine - March 22, 2024 Category: Complementary Medicine Authors: Xiaoyu Geng, Ying Wang, Huan Li, Liang Song, Chen Luo, Xiaojie Gu, Haixin Zhong, Huilin Chen, Xinzhu Chen, Jianwei Wang and Zheng Pan Tags: Research Source Type: research
Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis
Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, s... (Source: Chinese Medicine)
Source: Chinese Medicine - March 22, 2024 Category: Complementary Medicine Authors: Tian Chen, Lu Ding, Meiru Zhao, Siyu Song, Juan Hou, Xueyan Li, Min Li, Kai Yin, Xiangyan Li and Zeyu Wang Tags: Review Source Type: research
TCMNPAS: a comprehensive analysis platform integrating network formulaology and network pharmacology for exploring traditional Chinese medicine
The application of network formulaology and network pharmacology has significantly advanced the scientific understanding of traditional Chinese medicine (TCM) treatment mechanisms in disease. The field of herb... (Source: Chinese Medicine)
Source: Chinese Medicine - March 22, 2024 Category: Complementary Medicine Authors: Yishu Liu, Xue Li, Chao Chen, Nan Ding, Peiyong Zheng, Xiaoyun Chen, Shiyu Ma and Ming Yang Tags: Research Source Type: research
