Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
CONCLUSIONS: Our results demonstrate a previously unrecognized role of ATF3 in AAA development and progression, and ATF3 may serve as a novel therapeutic and prognostic marker for AAA.PMID:38686580 | DOI:10.1161/CIRCRESAHA.124.324323 (Source: Circulation Research)
Source: Circulation Research - April 30, 2024 Category: Cardiology Authors: Ying Wen Yingying Liu Qiang Li Jinlin Tan Xing Fu Yiwen Liang Yonghua Tuo Luhao Liu Xueqiong Zhou Dongkai LiuFu Xuejiao Fan Chaofei Chen Zheng Chen Zhouping Wang Shunyang Fan Renjing Liu Lei Pan Yuan Zhang Wai Ho Tang Source Type: research
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
CONCLUSIONS: Our results demonstrate a previously unrecognized role of ATF3 in AAA development and progression, and ATF3 may serve as a novel therapeutic and prognostic marker for AAA.PMID:38686580 | DOI:10.1161/CIRCRESAHA.124.324323 (Source: Circulation Research)
Source: Circulation Research - April 30, 2024 Category: Cardiology Authors: Ying Wen Yingying Liu Qiang Li Jinlin Tan Xing Fu Yiwen Liang Yonghua Tuo Luhao Liu Xueqiong Zhou Dongkai LiuFu Xuejiao Fan Chaofei Chen Zheng Chen Zhouping Wang Shunyang Fan Renjing Liu Lei Pan Yuan Zhang Wai Ho Tang Source Type: research
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
CONCLUSIONS: Our results demonstrate a previously unrecognized role of ATF3 in AAA development and progression, and ATF3 may serve as a novel therapeutic and prognostic marker for AAA.PMID:38686580 | DOI:10.1161/CIRCRESAHA.124.324323 (Source: Circulation Research)
Source: Circulation Research - April 30, 2024 Category: Cardiology Authors: Ying Wen Yingying Liu Qiang Li Jinlin Tan Xing Fu Yiwen Liang Yonghua Tuo Luhao Liu Xueqiong Zhou Dongkai LiuFu Xuejiao Fan Chaofei Chen Zheng Chen Zhouping Wang Shunyang Fan Renjing Liu Lei Pan Yuan Zhang Wai Ho Tang Source Type: research
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension
CONCLUSIONS: These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.PMID:38666386 | DOI:10.1161/CIRCRESAHA.123.323897 (Source: Circulation Research)
Source: Circulation Research - April 26, 2024 Category: Cardiology Authors: Jaya Krishnan Elizabeth M Hennen Mingfang Ao Annet Kirabo Taseer Ahmad N éstor de la Visitación David M Patrick Source Type: research
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension
CONCLUSIONS: These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.PMID:38666386 | DOI:10.1161/CIRCRESAHA.123.323897 (Source: Circulation Research)
Source: Circulation Research - April 26, 2024 Category: Cardiology Authors: Jaya Krishnan Elizabeth M Hennen Mingfang Ao Annet Kirabo Taseer Ahmad N éstor de la Visitación David M Patrick Source Type: research
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension
CONCLUSIONS: These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.PMID:38666386 | DOI:10.1161/CIRCRESAHA.123.323897 (Source: Circulation Research)
Source: Circulation Research - April 26, 2024 Category: Cardiology Authors: Jaya Krishnan Elizabeth M Hennen Mingfang Ao Annet Kirabo Taseer Ahmad N éstor de la Visitación David M Patrick Source Type: research
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension
CONCLUSIONS: These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.PMID:38666386 | DOI:10.1161/CIRCRESAHA.123.323897 (Source: Circulation Research)
Source: Circulation Research - April 26, 2024 Category: Cardiology Authors: Jaya Krishnan Elizabeth M Hennen Mingfang Ao Annet Kirabo Taseer Ahmad N éstor de la Visitación David M Patrick Source Type: research
Proteomics, Human Environmental Exposure, and Cardiometabolic Risk
Conclusions: Environmental exposures are related to an inflammatory-metabolic proteome, which identifies individuals with CMD and respiratory phenotypes and outcomes. Future work examining the dynamic impact of the environment on human cardiometabolic health is warranted.PMID:38662804 | DOI:10.1161/CIRCRESAHA.124.324559 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Andrew S Perry Kai Zhang Venkatesh L Murthy Bina Choi Shilin Zhao Priya Gajjar Laura A Colangelo Lifang Hou Mary Rice John Jeffrey Carr April P Carson Anne E Nigra Ramachandran S Vasan Robert E Gerszten Sadiya S Khan Ravi Kalhan Matthew Nayor Ravi V Shah Source Type: research
Association of Ecoregion Distribution of Greenness With Cardiovascular Mortality: A Longitudinal Ecological Study in the United States
Circ Res. 2024 Apr 26;134(9):1221-1223. doi: 10.1161/CIRCRESAHA.124.324427. Epub 2024 Apr 25.NO ABSTRACTPMID:38662855 | DOI:10.1161/CIRCRESAHA.124.324427 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Daniel W Riggs Natalie C DuPre Peter James Shesh N Rai Ray Yeager Clara G Sears Francine Laden Aruni Bhatnagar Source Type: research
Transportation Noise Pollution and Cardiovascular Health
Circ Res. 2024 Apr 26;134(9):1113-1135. doi: 10.1161/CIRCRESAHA.123.323584. Epub 2024 Apr 25.ABSTRACTEpidemiological studies have found that transportation noise increases the risk for cardiovascular morbidity and mortality, with solid evidence for ischemic heart disease, heart failure, and stroke. According to the World Health Organization, at least 1.6 million healthy life years are lost annually from traffic-related noise in Western Europe. Traffic noise at night causes fragmentation and shortening of sleep, elevation of stress hormone levels, and increased oxidative stress in the vasculature and the brain. These factor...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Thomas M ünzel Michael Molitor Marin Kuntic Omar Hahad Martin R öösli Nicole Engelmann Mathias Basner Andreas Daiber Mette S ørensen Source Type: research
Introduction to the Compendium On Environmental Impacts on Cardiovascular Health and Biology
Circ Res. 2024 Apr 26;134(9):1047. doi: 10.1161/CIRCRESAHA.124.324664. Epub 2024 Apr 25.NO ABSTRACTPMID:38662857 | DOI:10.1161/CIRCRESAHA.124.324664 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Naomi M Hamburg Kathryn J Moore Source Type: research
Exposure to Fine Particulate Matter Air Pollution Disrupts Erythrocyte Turnover
Circ Res. 2024 Apr 26;134(9):1224-1227. doi: 10.1161/CIRCRESAHA.124.324411. Epub 2024 Apr 25.NO ABSTRACTPMID:38662858 | DOI:10.1161/CIRCRESAHA.124.324411 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Haley Asplund Hector H Dreyer Richa Singhal Eric C Rouchka Timothy E O'Toole Petra Haberzettl Daniel J Conklin Brian E Sansbury Source Type: research
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Circ Res. 2024 Apr 26;134(9):1136-1159. doi: 10.1161/CIRCRESAHA.124.323697. Epub 2024 Apr 25.ABSTRACTConservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-for...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Jennifer J Schlezinger Noyan Gokce Source Type: research
Understanding the Cardiovascular and Metabolic Health Effects of Air Pollution in the Context of Cumulative Exposomic Impacts
Circ Res. 2024 Apr 26;134(9):1083-1097. doi: 10.1161/CIRCRESAHA.124.323673. Epub 2024 Apr 25.ABSTRACTPoor air quality accounts for more than 9 million deaths a year globally according to recent estimates. A large portion of these deaths are attributable to cardiovascular causes, with evidence indicating that air pollution may also play an important role in the genesis of key cardiometabolic risk factors. Air pollution is not experienced in isolation but is part of a complex system, influenced by a host of other external environmental exposures, and interacting with intrinsic biologic factors and susceptibility to ultimatel...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Haitham Khraishah Zhuo Chen Sanjay Rajagopalan Source Type: research
Heavy Metal Exposure and Cardiovascular Disease
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.ABSTRACTHeavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Ziwei Pan Tingyu Gong Ping Liang Source Type: research
