Effective bridging strategies prior to infusion with tisagenlecleucel results in high response rates and long-term remission in relapsed/refractory large B-cell lymphoma: findings from a German monocentric study
CONCLUSION: The study underscores the importance of minimal tumor burden at CAR-T initiation, emphasizing the need for suitable bridging regimens. The findings advocate for clinical trials and further real-world analyses to optimize CAR-T cell therapy outcomes by identifying the most effective bridging strategies.PMID:38693452 | DOI:10.1007/s00432-024-05765-8 (Source: Clin Med Res)
Source: Clin Med Res - May 1, 2024 Category: Research Authors: Farina Eigendorff Irina Filimonova Sebastian Scholl Anne Sayer-Klink Silke Rummler Christa Kunert Klaus Pietschmann Andrea Wittig Andreas Hochhaus Ulf Schnetzke Source Type: research
PPAR agonists in PBC: Where do we go from here? Or how to choose between the new and the old
Clin Res Hepatol Gastroenterol. 2024 Apr 25:102358. doi: 10.1016/j.clinre.2024.102358. Online ahead of print.ABSTRACTThe recent phase 3 trials of peroxisome proliferator-activated receptor (PPAR) agonists in primary biliary cholangitis (PBC) patients with incomplete response to ursodeoxycholic acid (UDCA) demonstrated very promising short-term biochemical responses. However, long-term outcomes, crucial in chronic diseases like PBC, remain uncertain. While real-world data (RWD) support surrogate endpoints, there's a need to validate long-term efficacy especially with combination therapies. Bezafibrate, an off-label option w...
Source: Clin Med Res - April 27, 2024 Category: Research Authors: Atsushi Tanaka Christophe Corpechot Source Type: research
PPAR agonists in PBC: Where do we go from here? Or how to choose between the new and the old
Clin Res Hepatol Gastroenterol. 2024 Apr 25:102358. doi: 10.1016/j.clinre.2024.102358. Online ahead of print.ABSTRACTThe recent phase 3 trials of peroxisome proliferator-activated receptor (PPAR) agonists in primary biliary cholangitis (PBC) patients with incomplete response to ursodeoxycholic acid (UDCA) demonstrated very promising short-term biochemical responses. However, long-term outcomes, crucial in chronic diseases like PBC, remain uncertain. While real-world data (RWD) support surrogate endpoints, there's a need to validate long-term efficacy especially with combination therapies. Bezafibrate, an off-label option w...
Source: Clin Med Res - April 27, 2024 Category: Research Authors: Atsushi Tanaka Christophe Corpechot Source Type: research
PPAR agonists in PBC: Where do we go from here? Or how to choose between the new and the old
Clin Res Hepatol Gastroenterol. 2024 Apr 25:102358. doi: 10.1016/j.clinre.2024.102358. Online ahead of print.ABSTRACTThe recent phase 3 trials of peroxisome proliferator-activated receptor (PPAR) agonists in primary biliary cholangitis (PBC) patients with incomplete response to ursodeoxycholic acid (UDCA) demonstrated very promising short-term biochemical responses. However, long-term outcomes, crucial in chronic diseases like PBC, remain uncertain. While real-world data (RWD) support surrogate endpoints, there's a need to validate long-term efficacy especially with combination therapies. Bezafibrate, an off-label option w...
Source: Clin Med Res - April 27, 2024 Category: Research Authors: Atsushi Tanaka Christophe Corpechot Source Type: research
PPAR agonists in PBC: Where do we go from here? Or how to choose between the new and the old
Clin Res Hepatol Gastroenterol. 2024 Apr 25:102358. doi: 10.1016/j.clinre.2024.102358. Online ahead of print.ABSTRACTThe recent phase 3 trials of peroxisome proliferator-activated receptor (PPAR) agonists in primary biliary cholangitis (PBC) patients with incomplete response to ursodeoxycholic acid (UDCA) demonstrated very promising short-term biochemical responses. However, long-term outcomes, crucial in chronic diseases like PBC, remain uncertain. While real-world data (RWD) support surrogate endpoints, there's a need to validate long-term efficacy especially with combination therapies. Bezafibrate, an off-label option w...
Source: Clin Med Res - April 27, 2024 Category: Research Authors: Atsushi Tanaka Christophe Corpechot Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
CONCLUSION: The available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design.PMID:38630378 | DOI:10.1007/s10286-024-01028-1 (Source: Clin Med Res)
Source: Clin Med Res - April 17, 2024 Category: Research Authors: Fabian Leys Sabine Eschlb öck Nicole Campese Philipp Mahlknecht Marina Peball Georg Goebel Victoria Sidoroff Florian Krismer Roberta Granata Stefan Kiechl Werner Poewe Klaus Seppi Gregor K Wenning Alessandra Fanciulli Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
CONCLUSION: The available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design.PMID:38630378 | DOI:10.1007/s10286-024-01028-1 (Source: Clin Med Res)
Source: Clin Med Res - April 17, 2024 Category: Research Authors: Fabian Leys Sabine Eschlb öck Nicole Campese Philipp Mahlknecht Marina Peball Georg Goebel Victoria Sidoroff Florian Krismer Roberta Granata Stefan Kiechl Werner Poewe Klaus Seppi Gregor K Wenning Alessandra Fanciulli Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
CONCLUSION: The available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design.PMID:38630378 | DOI:10.1007/s10286-024-01028-1 (Source: Clin Med Res)
Source: Clin Med Res - April 17, 2024 Category: Research Authors: Fabian Leys Sabine Eschlb öck Nicole Campese Philipp Mahlknecht Marina Peball Georg Goebel Victoria Sidoroff Florian Krismer Roberta Granata Stefan Kiechl Werner Poewe Klaus Seppi Gregor K Wenning Alessandra Fanciulli Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
CONCLUSION: The available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design.PMID:38630378 | DOI:10.1007/s10286-024-01028-1 (Source: Clin Med Res)
Source: Clin Med Res - April 17, 2024 Category: Research Authors: Fabian Leys Sabine Eschlb öck Nicole Campese Philipp Mahlknecht Marina Peball Georg Goebel Victoria Sidoroff Florian Krismer Roberta Granata Stefan Kiechl Werner Poewe Klaus Seppi Gregor K Wenning Alessandra Fanciulli Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
CONCLUSION: The available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design.PMID:38630378 | DOI:10.1007/s10286-024-01028-1 (Source: Clin Med Res)
Source: Clin Med Res - April 17, 2024 Category: Research Authors: Fabian Leys Sabine Eschlb öck Nicole Campese Philipp Mahlknecht Marina Peball Georg Goebel Victoria Sidoroff Florian Krismer Roberta Granata Stefan Kiechl Werner Poewe Klaus Seppi Gregor K Wenning Alessandra Fanciulli Source Type: research
Response to kollas. Letter to the editor, "problems with opioids beyond misuse"
Best Pract Res Clin Rheumatol. 2024 Apr 13:101946. doi: 10.1016/j.berh.2024.101946. Online ahead of print.NO ABSTRACTPMID:38616455 | DOI:10.1016/j.berh.2024.101946 (Source: Clin Med Res)
Source: Clin Med Res - April 15, 2024 Category: Research Authors: Deeba Minhas Dorna Kheirabadi Rezvan Ghaderpanah Daniel J Clauw Source Type: research
Response to kollas. Letter to the editor, "problems with opioids beyond misuse"
Best Pract Res Clin Rheumatol. 2024 Apr 13:101946. doi: 10.1016/j.berh.2024.101946. Online ahead of print.NO ABSTRACTPMID:38616455 | DOI:10.1016/j.berh.2024.101946 (Source: Clin Med Res)
Source: Clin Med Res - April 15, 2024 Category: Research Authors: Deeba Minhas Dorna Kheirabadi Rezvan Ghaderpanah Daniel J Clauw Source Type: research
Utilization and quality of palliative care in patients with hematological and solid cancers: a population-based study
CONCLUSION: The data highlight the need to integrate PC more often, earlier, and more effectively into the care of patients with HM.PMID:38607376 | PMC:PMC11014814 | DOI:10.1007/s00432-024-05721-6 (Source: Clin Med Res)
Source: Clin Med Res - April 12, 2024 Category: Research Authors: Cordula Gebel Bianka Ditscheid Franziska Meissner Ekaterina Slotina Isabel Kruschel Ursula Marschall Ullrich Wedding Antje Freytag Source Type: research
Air Embolism-Induced Ischemic Stroke Following Orthognathic Surgery in a Patient With Goldenhar Syndrome
Clin Med Res. 2024 Mar;22(1):44-48. doi: 10.3121/cmr.2024.1882.ABSTRACTGoldenhar syndrome, a rare congenital anomaly, manifests as craniofacial malformations often necessitating intricate surgical interventions. These procedures, though crucial, can expose patients to diverse postoperative complications, including hemorrhage or infection. A noteworthy complication is stroke, potentially linked to air embolism or local surgical trauma. We highlight a case of a male patient, aged 20 years, who experienced a significant postoperative complication of an ischemic stroke, theorized to be due to an air embolism, after undergoing ...
Source: Clin Med Res - April 12, 2024 Category: Research Authors: Apurva Popat Sweta Yadav Source Type: research
Clinical Presentation of Blastomycosis is Associated With Infecting Species, Not Host Genotype
Conclusions: Our study did not identify any genetic risk factors for blastomycosis. Instead, the species of Blastomyces causing the infection had a significant effect on disease severity.PMID:38609141 | DOI:10.3121/cmr.2024.1880 (Source: Clin Med Res)
Source: Clin Med Res - April 12, 2024 Category: Research Authors: Alexandra M Linz Holly M Frost Terrie Kitchner Jennifer L Anderson Jennifer Meece Source Type: research
