Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

NKG2C+CD57+ natural killer with senescent features cells are induced in cutaneous leishmaniasis and accumulate in patients with lesional healing impairment
This study provides a broad understanding of the NK cell biology during Leishmania infection and reinforces the role of senescent cells in the adverse clinical outcomes of cutaneous leishmaniasis.PMID:38700066 | DOI:10.1093/cei/uxae040 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Luciana Polaco Covre Carlos Henrique Fantecelle Ariadne Mendes Queiroz Julia Miranda Fardin Pedro Henrique Miranda Sian Henson Alessandra Marcia da Fonseca-Martins Herbert Leonel de Matos Guedes David Mosser Aloisio Falqueto Arne Akbar Daniel Claudio Oliv Source Type: research

Impact on in-depth immunophenotyping of delay to peripheral blood processing
Clin Exp Immunol. 2024 May 2:uxae041. doi: 10.1093/cei/uxae041. Online ahead of print.ABSTRACTPeripheral blood mononuclear cell (PBMC) immunophenotyping is crucial in tracking activation, disease state, and response to therapy in human subjects. Many studies require shipping of blood from clinical sites to a laboratory for processing to PBMC, which can lead to delays that impact sample quality. We used an extensive cytometry by time-of-flight (CyTOF) immunophenotyping panel to analyze the impacts of delays to processing and distinct storage conditions on cell composition and quality of PBMC from seven adults across a range...
Source: Clinical and Developmental Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Lauren E Higdon Sheila Scheiding Anna M Kus Noha Lim S Alice Long Mark S Anderson Alice E Wiedeman Source Type: research

Follow-up of Immune Response in Patients with Common Variable Immunodeficiency following SARS-CoV-2 Vaccination
In this study, we evaluated the humoral and cellular immune responses after four doses of mRNA-1273 and one BNT162b2 bivalent vaccine in a cohort of patients with CVID and XLA. The response in this population was lower than in the control group. However, the administration of the third dose improved the number of patients with seroconversion and the intensity of the humoral response, as well as the number of patients with a positive cellular response. Finally, the administration of the fourth and fifth doses improves the antibody titer and neutralization against wild type variant, but not against the prevalent XBB1.5 varia...
Source: Clinical and Developmental Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Juan Francisco Guti érrez-Bautista Irene D íaz-Alberola Mar ía Tarriño Mar ía Aguilera Fernando Cobo Juan Antonio Reguera Javier Rodr íguez-Granger Joaqu ín Mendoza Miguel Ángel López-Nevot Antonio Sampedro Source Type: research

Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns (PAMPs) that is distinct from adult blood cells
Clin Exp Immunol. 2024 May 2:uxae034. doi: 10.1093/cei/uxae034. Online ahead of print.ABSTRACTNeonate responses to pathogen-associated molecular patterns (PAMPS) differ from adults; such understanding is poor in Indian neonates, despite recognised significant infectious risk. Immune profiling analysis was undertaken of ten secreted mediators contextualised with cellular source induced by six PAMPs in umbilical cord (CB; n=21) and adult-blood (PBMC, n=14) from a tertiary care hospital in South India. Differential cytokine expression analysis (minimum log2-fold difference; adj p-value<0.05) identified bacterial PAMPs indu...
Source: Clinical and Developmental Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Vasista Adiga Hima Bindhu Asma Ahmed Nirutha Chetan Kumar Himanshu Tripathi George D'Souza Mary Dias Sudarshan Shivalingaiah Srishti Rao K N Shanti Catherine Hawrylowicz Pratibha Dwarkanath Annapurna Vyakarnam Source Type: research

Exploring the Causal Role of Immune Cells in Cerebral Aneurysm Through Single-Cell Transcriptomics and Mendelian Randomization Analysis
This study aims to explore the complex interplay between immune cells and CA formation. We analyzed single-cell RNA sequencing data from the GSE193533 dataset, focusing on unruptured CA and their controls. Comprehensive cell-type identification and pseudotime trajectory analyses were conducted to delineate the dynamic shifts in immune cell populations. Additionally, a two-sample Mendelian Randomization (MR) approach was employed to investigate the causal influence of various immunophenotypes on CA susceptibility and the reciprocal effect of CA formation on immune phenotypes. Single-cell transcriptomic analysis revealed a p...
Source: Clinical and Developmental Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Yunhu Yu Shiao Tong Tao Liu Yunpeng Cai Yuanmei Song Hang Zhou Rongcai Jiang Source Type: research

IL-22, a vital cytokine in autoimmune diseases
Clin Exp Immunol. 2024 Apr 23:uxae035. doi: 10.1093/cei/uxae035. Online ahead of print.ABSTRACTInterleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune dis...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Jiajin Li Zhen Wu Yuxin Wu Xin Yu Hu Jun Yang Dacheng Zhu Mingyue Wu Xin Li Lutterodt Bentum-Ennin Wanglai Hu Source Type: research

Genomic Testing Identifies Monogenic Causes in Patients with Very Early-Onset Inflammatory Bowel Disease: A Multi-center Survey in an Iranian Cohort
Clin Exp Immunol. 2024 Apr 23:uxae037. doi: 10.1093/cei/uxae037. Online ahead of print.ABSTRACTPatients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a me...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Golnaz Eslamian Mahnaz Jamee Tooba Momen Pejman Rohani Sarehossadat Ebrahimi Mehrnaz Mesdaghi Soodeh Ghadimi Mahboubeh Mansouri Seyed Alireza Mahdaviani Mahnaz Sadeghi-Shabestari Morteza Fallahpour Bibi Shahin Shamsian Narges Eslami Samin Sharafian Naghi Source Type: research

NK-like CD8 T Cell: One Potential Evolutionary Continuum between Adaptive Memory and Innate Immunity
Clin Exp Immunol. 2024 Apr 23:uxae038. doi: 10.1093/cei/uxae038. Online ahead of print.ABSTRACTCD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T cell pool is influenced by various factors. Physiological aging, chronic viral infection, and autoimmune diseases promote the accumulation of CD8 T cells with highly differentiated memory phenotypes. Accumulating studies have shown that some of these memory CD8 T cells also exhibit innate-like cytotoxicity and ...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Qiulei Wang Shaodan Chen Zhenhong Guo Sheng Xia Minghui Zhang Source Type: research