Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Curcumol reduces lower limb arteriosclerosis in rats by inhibiting human arterial smooth muscle cell activity
This study aimed to investigate the therapeutic potential of curcumol in inhibiting platelet-derived growth factor-BB (PDGF-BB)-induced human aortic smooth muscle cell (HASMC) proliferation, migration and autophagy. Using cell viability assays, 5-ethynyl-2'-deoxyuridine (EdU) incorporation assays and Western Blot analyses, we observed that curcumol effectively attenuated PDGF-BB-induced HASMC proliferation and migration in a concentration-dependent manner. Furthermore, curcumol mitigated PDGF-BB-induced autophagy, as evidenced by the downregulation of LC3-II/LC3-I ratio and upregulation of P62. In vivo experiments using an...
Source: Clinical and Experimental Pharmacology and Physiology - April 29, 2024 Category: Drugs & Pharmacology Authors: Shengzhuang Yang Gaosheng Huang Xiangsen Liang Yu Sun Lei Xian Source Type: research

N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma
In this study, we observed that m6A regulators methyltransferase like protein (METTL14) and insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) were upregulated in HPV-positive CSCC tissues and cell lines, and their high expression predicted poor prognosis for HPV-infected CSCC patients. Cellular functional experiments verified that HPV16 oncogenes E6/E7 upregulated the expression of METTL14 and IGF2BP3 to promote cell proliferation and epithelial mesenchymal transition of CSCC cells. Next, we found that E6/E7 stabilized fascin actin-bundling protein 1 (FSCN1) mRNA and elevated FSCN1 expression in CSCC cells thro...
Source: Clinical and Experimental Pharmacology and Physiology - April 28, 2024 Category: Drugs & Pharmacology Authors: Qingqing Tian Juqing Huang Qin Zhang Jufen Zhao Source Type: research

A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract
This study first reported cognitive deficits in a spontaneous hyperglycaemia NHPs, which might provide evidence to use macaque as a promising model for translational research in diabetes and neurological complications.PMID:38650114 | DOI:10.1111/1440-1681.13863 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 23, 2024 Category: Drugs & Pharmacology Authors: Hongdi Huang Jianglin Pu Yufang Zhou Yang Fan Yali Zhang Yanling Li Yangzhuo Chen Yun Wang Xiaomei Yu Bulgin Dmitry Zhu Zhou Jianhong Wang Source Type: research

Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009-2010
Clin Exp Pharmacol Physiol. 2024 Jun;51(6):e13859. doi: 10.1111/1440-1681.13859.ABSTRACTPrevious study has demonstrated that the Dietary Inflammation Index (DII) played a role in the risk of inflammatory bowel disease (IBD), however, the prevalence and risk factors for IBD are distinct across locations and groups, and therefore, the findings are debatable and warrant further investigation. A total of 4363 participants were calculated in the National Health and Nutrition Examination Survey (NHANES) 2009 to 2010, of whom 1.21% self-reported a history of IBD. DII values were performed as a good predictor of dietary inflammati...
Source: Clinical and Experimental Pharmacology and Physiology - April 21, 2024 Category: Drugs & Pharmacology Authors: Jing-Yi Zhu Xiao-Ru Sun Mu-Yun Liu Chang Sun Source Type: research

Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage
This study aimed to assess the neuroprotective effects of loganin in a rat ICH model. Sprague-Dawley rats were used, subjected to a collagenase-induced ICH model, followed by loganin treatment at doses of 2.5, 5 and 10 mg/kg. Neurological functions were evaluated using the modified neurological severity score (mNSS) and a rotarod test. Results indicated a significant improvement in neurological functions in loganin-treated groups, evident from the mNSS and rotarod tests, suggesting dose-dependent neuroprotection. Loganin also effectively reduced the blood-brain barrier (BBB) permeability and cerebral oedema. Additionally, ...
Source: Clinical and Experimental Pharmacology and Physiology - April 18, 2024 Category: Drugs & Pharmacology Authors: Yu Wang Min Zhao Jing Li Yue Liu Source Type: research

Salvianic acid A sodium facilitates cardiac microvascular endothelial cell proliferation by enhancing the hypoxia-inducible factor-1 alpha/vascular endothelial growth factor signalling pathway post-myocardial infarction
Clin Exp Pharmacol Physiol. 2024 Jun;51(6):e13855. doi: 10.1111/1440-1681.13855.ABSTRACTCardiac microvascular endothelial cells (CMECs) are important cells surrounding the cardiomyocytes in the heart that maintain microenvironment homeostasis. Salvianic acid A sodium (SAAS) has been reported to prevent myocardial infarction (MI) injury. However, the role of SAAS on CMEC proliferation remains unclear. CEMCs exposed to oxygen glucose deprivation (OGD) were used to explore the angiogenic abilities of SAAS. In vivo, C57BL/6 mice were divided into three groups: sham, MI and SAAS + MI groups. Compared to OGD group, SAAS led to a...
Source: Clinical and Experimental Pharmacology and Physiology - April 18, 2024 Category: Drugs & Pharmacology Authors: Jichun Liu Fei Wu Zhenhan Li Shengwei Zheng Yanqiang Huang Hao Chen Source Type: research

Correction to "GSK3 β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycemic subarachnoid haemorrhage rats"
Clin Exp Pharmacol Physiol. 2024 Jun;51(6):e13853. doi: 10.1111/1440-1681.13853.NO ABSTRACTPMID:38636943 | DOI:10.1111/1440-1681.13853 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 18, 2024 Category: Drugs & Pharmacology Source Type: research

Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research

Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/ β-catenin cascade inactivation
In conclusion, our findings suggest that the inhibition of CRC cell proliferation by SIRT3 is closely associated with the inactivation of the Wnt/β-catenin signalling pathway.PMID:38621772 | DOI:10.1111/1440-1681.13856 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: Tianyu Li Leqi Fan Yijiang Jia Chen Xu Wei Guo Yuji Wang Ye Li Source Type: research