V600E BRAF-mutated anaplastic thyroid carcinoma after radioactive iodine for Graves ’ disease: a case report and a review of the literature
DiscussionIt is not clear if the occurrence of ATC could be influenced by the RAI therapy for hyperthyroidism. Therefore, we reviewed the different cases and characteristics of ATC after RAI published so far in the literature. Patients were exclusively females, the median age at diagnosis was 66,5 years old (IQR: 51,5–69, range 29–75) and the median time occurring from RAI treatment and ATC diagnosis was 7 years. To our knowledge, here we report the first patient with V600E BRAF-mutation in ATC after RAI for Graves’ disease. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 18, 2024 Category: Radiology Source Type: research
Prognostic significance of [18F]FDG PET metabolic parameters in osteosarcoma and Ewing ’s sarcoma: a systematic review and network meta-analysis
ConclusionOur study suggested that [18F]FDG PET parameters, particularly SUV2, MTV1, and TLG1, have significant prognostic value in patients with OST and EWS. Further research involving larger cohorts and standardized methodologies is essential to confirm and build upon these findings. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 13, 2024 Category: Radiology Source Type: research
PET imaging of dopaminergic system and clinical applications
ConclusionThere is a large number of dopaminergic PET radiotracers which help to detect or diagnose diseases of the various systems in which dopaminergic system is involved. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 13, 2024 Category: Radiology Source Type: research
Correction: Value of 2-[18 F]FDG-PET/CT in identifying immune-related adverse events in patients with melanoma or non-small cell lung cancer: a systematic scoping review
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 13, 2024 Category: Radiology Source Type: research
PET imaging in the psoriasis and psoriatic arthritis field: un update
ConclusionsThe possibility of the evaluation of inflammation in different sites can be used to evaluate both systemic, articular and periarticular inflammation, giving the possibility of a comprehensive assessment of the patients. The emerging clinical needs for novel biomarkers in the psoriasis field can be potentially supported by novel biomarkers on FDG PET imaging in several research settings but further multicentric trials are needed for the implementation in the clinical practice. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 10, 2024 Category: Radiology Source Type: research
Long-term effects on parathyroid function and risk factors for permanent hypoparathyroidism in post-surgical differentiated thyroid cancer patients treated with 131I: a retrospective analysis of clinical data
ConclusionsPostoperative131I therapy for DTC has no significant adverse effects on the parathyroid function within three years, but extremely few patients still develop permanent HPT, with an increased risk in those with functional metastases in the first131I-WBS. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 10, 2024 Category: Radiology Source Type: research
Considerations on the preliminary results of the NETTER-2 trial: is the glass half full or half empty?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 7, 2024 Category: Radiology Source Type: research
Impact of gadolinium-based contrast agents on attenuation correction and tracer quantification in neuroendocrine malignancies in [68Ga]-DOTATOC PET/MRI
ConclusionNo major deviations between the measured values in pre- and post-contrast attenuation-corrected PET images have been observed. Minor alterations may occur due to the application of a contrast medium. This has to be accounted for in patients undergoing repeated PET/MR imaging, especially in the context of therapy monitoring.Advances in knowledgeOur lesion-based analysis examines the impact of gadolinium-based contrast agents on attenuation correction of PET/MRI and the subsequent influence on tracer quantification. Our lesion based approach did not found any major differences between both assessments, indicating t...
Source: Clinical and Translational Imaging - April 25, 2024 Category: Radiology Source Type: research
Investigating the diffuse pancreatic expression of [68Ga]Ga-DOTA-FAPI: location, timing, and molecular imaging approaches
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 23, 2024 Category: Radiology Source Type: research
The diagnostic performance of [18F]FDG PET/CT in the detection of melanoma recurrence: a systematic review and meta-analysis
ConclusionIt finds that [18F]FDG PET/CT has excellent diagnosis performance in identifying malignant melanoma recurrence. Its application could improve patient prognosis by detecting and treating recurrences earlier. Further studies need more prospective large samples. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 23, 2024 Category: Radiology Source Type: research
Interobserver assessment of metabolic patterns in progressive primary aphasia through the application of [18F]-Fluorodeoxiglucose PET/CT
ConclusionOverall, the findings of the present study are consistent with previous research on the use of [18F]-FDG PET/CT in the evaluation of PPA. The study adds to the existing literature by demonstrating the utility of [18F]-FDG PET/CT in differentiating the variants of primary progressive aphasia and by evaluating interobserver variability in image interpretation. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 22, 2024 Category: Radiology Source Type: research
Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis
Conclusion[68Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [18F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [18F]FDG PET and [68Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 15, 2024 Category: Radiology Source Type: research
Early response assessment to targeted therapy in metastatic clear cell renal cancer using 68Ga-PSMA-11 PET/CT and comparison with CECT: a feasibility study
ConclusionEarly response assessment with68Ga-PSMA-11 PET/CT is feasible and provides more accurate prognostic information than CECT in metastatic clear cell RCC patients undergoing targeted therapy.Trial registration numberCTRI/2021/05/033805 (date of registration: 25/05/21) (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 9, 2024 Category: Radiology Source Type: research
[18F]FDG PET/CT imaging of spinal infections
AbstractThe annual incidence of spinal infections has been rising significantly over the last years and is expected to increase even further. Spinal infections may include infection of the vertebral body and intervertebral disc (spondylodiscitis), paravertebral abscess, epidural abscess and septic arthritis of the facet joints. Positron emission tomography (PET) with [18F]FDG has high sensitivity for detecting spinal infections, may help in differentiating between spinal infection subtypes and is able to detect dissemination of infection outside the spine. [18F]FDG PET/CT is especially indicated if MRI is inconclusive, in ...
Source: Clinical and Translational Imaging - April 8, 2024 Category: Radiology Source Type: research
Pediatric congenital pulmonary malformations: key findings at imaging
AbstractPediatric congenital pulmonary malformations are rare abnormalities which may affect airways, pulmonary parenchyma, and vasculature and diagnostic imaging plays a significant role in their identification and characterization. Although, nowadays, often the diagnosis of this heterogeneous group of malformations is performed prenatally by ultrasound and/or fetal magnetic resonance, after birth, computed tomography represents the main technique. Radiographs are often used as first line diagnostic tool while magnetic resonance demonstrated to be especially beneficial to investigate some malformations such as bronchogeni...
Source: Clinical and Translational Imaging - April 2, 2024 Category: Radiology Source Type: research
