Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson ’s disease
ConclusionsThe presence of at least two ABPM-hypotensive episodes independently predicted the development of falls, dementia, and hospitalization, showing a stronger prognostic value than the simple bedside assessment. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 25, 2024 Category: Research Source Type: research
A case report illustrating the ‘hypotensive twilight zone’ in Parkinson’s disease; an under-recognised presentation of orthostatic hypotension
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 25, 2024 Category: Research Source Type: research
Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson ’s disease
ConclusionThe ∆BPVM2 parameter of the VM may help detect autonomic nervous system involvement in early-PD without OH. Our results suggest that sympathetic dysfunction is an early manifestation of autonomic dysfunction in patients with PD. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 23, 2024 Category: Research Source Type: research
Dysautonomia and response to guanfacine in individuals with an SCN9A variant
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 23, 2024 Category: Research Source Type: research
Sex-related differences in the clinical presentation of multiple system atrophy
ConclusionThe available literature and findings of the present study indicate sex-related differences in the clinical presentation of MSA and its evolution over time, highlighting the importance of considering sex in symptom exploration, therapeutic decision-making, and future clinical trial design. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 17, 2024 Category: Research Source Type: research
Supine hypertension is longitudinally associated with verbal memory decline in Parkinson disease
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 30, 2024 Category: Research Source Type: research
Effective non-invasive ventilation reduces muscle sympathetic nerve activity in patients with stable hypercapnic COPD
This study determined the impact of non-invasive ventilation (NIV) on muscle sympathetic nerve activity (MSNA) in patients with stable hypercapnic COPD. Ten patients (age 70 ± 7 years, GOLD stage 3–4) receiving long-term NIV (mean inspiratory positive airway pressure 21 ± 7 cmH2O) underwent invasive MSNA measurement via the peroneal nerve during spontaneous breathing and NIV. Compared with spontaneous breathing, NIV significantly reduced hypercapnia (PaCO2 51.5 ± 6.9 vs 42.6 ± 6.1 mmHg,p < 0.0001) along with the burst rate (64.4 ± 20.9 vs 59.2 ± 19.9 bursts/min,p = 0.03) an...
Source: Clinical Autonomic Research - March 19, 2024 Category: Research Source Type: research
Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function
ConclusionsThe results of this observational cohort study confirm those based on our case report and lead us to propose that even in the setting of vascular-sympathetic baroreflex failure orthostasis increases HF power of BP variability. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 6, 2024 Category: Research Source Type: research
In memoriam: a celebration of the autonomic contributions of David Robertson (1947 –2024)
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 4, 2024 Category: Research Source Type: research
Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study
ConclusionLevodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3 min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 2, 2024 Category: Research Source Type: research
Clinical Autonomic Research: welcome to 2024
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 28, 2024 Category: Research Source Type: research
In Memoriam: Carl-Albrecht Haensch, M.D.
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 26, 2024 Category: Research Source Type: research
Acknowledgment to Reviewers
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 26, 2024 Category: Research Source Type: research
